Skip to main content
Top
Published in: Japanese Journal of Radiology 1/2018

01-01-2018 | Original Article

Dosimetric comparison of 3-dimensional conformal radiotherapy, volumetric modulated arc therapy, and helical tomotherapy for postoperative gastric cancer patients

Authors: Cem Onal, Yemliha Dölek, Berna Akkuş Yıldırım

Published in: Japanese Journal of Radiology | Issue 1/2018

Login to get access

Abstract

Purpose

To compare dosimetric data for the planning target volume (PTV) and organs at risk (OARs) between 3-dimensional conformal radiotherapy (3DCRT), volumetric modulated arc therapy (VMAT), and helical tomotherapy [1].

Materials and methods

The dosimetric data for 15 gastric cancer patients treated with 3DCRT, VMAT, or HT techniques were used. Cumulative dosimetric parameters, homogeneity index (HI), and conformal index (CI) were compared for the PTV and OARs.

Results

The average maximum doses of PTV were significantly higher in VMAT plans than in 3DCRT (p = 0.04) and HT (p = 0.02) plans, whereas minimum dose values were significantly lower in 3DCRT plans compared with VMAT (p < 0.001) and HT (p = 0.02) plans. Liver mean dose (D mean) and D mean values for both kidneys were significantly lower in HT plans than in 3DCRT and VMAT plans. The doses in high dose regions (V30–V45) using 3DCRT plans were significantly higher compared to both VMAT and HT plans. The bowel V5–V30 and V45 was significantly less in HT plans compared to VMAT plans. There were no significant differences in dose sparing of the spinal cord.

Conclusions

The HT plans reduced the maximum dose applied to the target and improved the conformality and homogeneity of radiation, while providing sufficient PTV coverage.
Literature
1.
go back to reference Olatunji BO, Ebesutani C, Sawchuk CN, et al. Development and initial validation of the medical fear survey-short version. Assessment. 2012;19(3):318–36.PubMedCrossRef Olatunji BO, Ebesutani C, Sawchuk CN, et al. Development and initial validation of the medical fear survey-short version. Assessment. 2012;19(3):318–36.PubMedCrossRef
2.
go back to reference Miller KD, Siegel RL, Lin CC, et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016;66(4):271–89.PubMedCrossRef Miller KD, Siegel RL, Lin CC, et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016;66(4):271–89.PubMedCrossRef
3.
go back to reference Gunderson LL, Sosin H. Adenocarcinoma of the stomach: areas of failure in a re-operation series (second or symptomatic look) clinicopathologic correlation and implications for adjuvant therapy. Int J Radiat Oncol Biol Phys. 1982;8(1):1–11.PubMedCrossRef Gunderson LL, Sosin H. Adenocarcinoma of the stomach: areas of failure in a re-operation series (second or symptomatic look) clinicopathologic correlation and implications for adjuvant therapy. Int J Radiat Oncol Biol Phys. 1982;8(1):1–11.PubMedCrossRef
4.
go back to reference Macdonald JS, Smalley SR, Benedetti J, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001;345(10):725–30.PubMedCrossRef Macdonald JS, Smalley SR, Benedetti J, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001;345(10):725–30.PubMedCrossRef
5.
go back to reference Valentini V, Cellini F, Minsky BD, et al. Survival after radiotherapy in gastric cancer: systematic review and meta-analysis. Radiother Oncol. 2009;92(2):176–83.PubMedCrossRef Valentini V, Cellini F, Minsky BD, et al. Survival after radiotherapy in gastric cancer: systematic review and meta-analysis. Radiother Oncol. 2009;92(2):176–83.PubMedCrossRef
6.
go back to reference Kim S, Lim DH, Lee J, et al. An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach. Int J Radiat Oncol Biol Phys. 2005;63(5):1279–85.PubMedCrossRef Kim S, Lim DH, Lee J, et al. An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach. Int J Radiat Oncol Biol Phys. 2005;63(5):1279–85.PubMedCrossRef
7.
go back to reference Kam MK, Chau RM, Suen J, et al. Intensity-modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation. Int J Radiat Oncol Biol Phys. 2003;56(1):145–57.PubMedCrossRef Kam MK, Chau RM, Suen J, et al. Intensity-modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation. Int J Radiat Oncol Biol Phys. 2003;56(1):145–57.PubMedCrossRef
8.
go back to reference Hummel S, Simpson EL, Hemingway P, et al. Intensity-modulated radiotherapy for the treatment of prostate cancer: a systematic review and economic evaluation. Health Technol Assess. 2010;14(47):1–108.PubMedCrossRef Hummel S, Simpson EL, Hemingway P, et al. Intensity-modulated radiotherapy for the treatment of prostate cancer: a systematic review and economic evaluation. Health Technol Assess. 2010;14(47):1–108.PubMedCrossRef
9.
go back to reference Alani S, Soyfer V, Strauss N, et al. Limited advantages of intensity-modulated radiotherapy over 3D conformal radiation therapy in the adjuvant management of gastric cancer. Int J Radiat Oncol Biol Phys. 2009;74(2):562–6.PubMedCrossRef Alani S, Soyfer V, Strauss N, et al. Limited advantages of intensity-modulated radiotherapy over 3D conformal radiation therapy in the adjuvant management of gastric cancer. Int J Radiat Oncol Biol Phys. 2009;74(2):562–6.PubMedCrossRef
10.
go back to reference Milano MT, Garofalo MC, Chmura SJ, et al. Intensity-modulated radiation therapy in the treatment of gastric cancer: early clinical outcome and dosimetric comparison with conventional techniques. Br J Radiol. 2006;79(942):497–503.PubMedCrossRef Milano MT, Garofalo MC, Chmura SJ, et al. Intensity-modulated radiation therapy in the treatment of gastric cancer: early clinical outcome and dosimetric comparison with conventional techniques. Br J Radiol. 2006;79(942):497–503.PubMedCrossRef
11.
go back to reference Li Z, Zeng J, Wang Z, et al. Dosimetric comparison of intensity modulated and volumetric arc radiation therapy for gastric cancer. Oncol Lett. 2014;8(4):1427–34.PubMedPubMedCentral Li Z, Zeng J, Wang Z, et al. Dosimetric comparison of intensity modulated and volumetric arc radiation therapy for gastric cancer. Oncol Lett. 2014;8(4):1427–34.PubMedPubMedCentral
12.
go back to reference Zhang T, Liang ZW, Han J, et al. Double-arc volumetric modulated therapy improves dose distribution compared to static gantry IMRT and 3D conformal radiotherapy for adjuvant therapy of gastric cancer. Radiat Oncol. 2015;10:114.PubMedPubMedCentralCrossRef Zhang T, Liang ZW, Han J, et al. Double-arc volumetric modulated therapy improves dose distribution compared to static gantry IMRT and 3D conformal radiotherapy for adjuvant therapy of gastric cancer. Radiat Oncol. 2015;10:114.PubMedPubMedCentralCrossRef
13.
go back to reference Wang X, Li G, Zhang Y, et al. Single-arc volumetric-modulated arc therapy (sVMAT) as adjuvant treatment for gastric cancer: dosimetric comparisons with three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT). Med Dosim. 2013;38(4):395–400.PubMedCrossRef Wang X, Li G, Zhang Y, et al. Single-arc volumetric-modulated arc therapy (sVMAT) as adjuvant treatment for gastric cancer: dosimetric comparisons with three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT). Med Dosim. 2013;38(4):395–400.PubMedCrossRef
14.
go back to reference Dahele M, Skinner M, Schultz B, et al. Adjuvant radiotherapy for gastric cancer: a dosimetric comparison of 3-dimensional conformal radiotherapy, tomotherapy and conventional intensity modulated radiotherapy treatment plans. Med Dosim. 2010;35(2):115–21.PubMedCrossRef Dahele M, Skinner M, Schultz B, et al. Adjuvant radiotherapy for gastric cancer: a dosimetric comparison of 3-dimensional conformal radiotherapy, tomotherapy and conventional intensity modulated radiotherapy treatment plans. Med Dosim. 2010;35(2):115–21.PubMedCrossRef
15.
go back to reference Pardo-Montero J, Fenwick JD. An approach to multiobjective optimization of rotational therapy. Med Phys. 2009;36(7):3292–303.PubMedCrossRef Pardo-Montero J, Fenwick JD. An approach to multiobjective optimization of rotational therapy. Med Phys. 2009;36(7):3292–303.PubMedCrossRef
16.
go back to reference Taylor R, Opfermann K, Jones BD, et al. Comparison of radiation treatment delivery for pancreatic cancer: linac intensity-modulated radiotherapy versus helical tomotherapy. J Med Imaging Radiat Oncol. 2012;56(3):332–7.PubMedCrossRef Taylor R, Opfermann K, Jones BD, et al. Comparison of radiation treatment delivery for pancreatic cancer: linac intensity-modulated radiotherapy versus helical tomotherapy. J Med Imaging Radiat Oncol. 2012;56(3):332–7.PubMedCrossRef
17.
go back to reference Otto K. Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys. 2008;35(1):310–7.PubMedCrossRef Otto K. Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys. 2008;35(1):310–7.PubMedCrossRef
18.
go back to reference Onal C, Arslan G, Parlak C, et al. Comparison of IMRT and VMAT plans with different energy levels using Monte-Carlo algorithm for prostate cancer. Jpn J Radiol. 2014;32(4):224–32.PubMedCrossRef Onal C, Arslan G, Parlak C, et al. Comparison of IMRT and VMAT plans with different energy levels using Monte-Carlo algorithm for prostate cancer. Jpn J Radiol. 2014;32(4):224–32.PubMedCrossRef
19.
go back to reference Wu VW, Kwong DL, Sham JS. Target dose conformity in 3-dimensional conformal radiotherapy and intensity modulated radiotherapy. Radiother Oncol. 2004;71(2):201–6.PubMedCrossRef Wu VW, Kwong DL, Sham JS. Target dose conformity in 3-dimensional conformal radiotherapy and intensity modulated radiotherapy. Radiother Oncol. 2004;71(2):201–6.PubMedCrossRef
20.
go back to reference Tepper JE, Gunderson LL. Radiation treatment parameters in the adjuvant postoperative therapy of gastric cancer. Semin Radiat Oncol. 2002;12(2):187–95.PubMedCrossRef Tepper JE, Gunderson LL. Radiation treatment parameters in the adjuvant postoperative therapy of gastric cancer. Semin Radiat Oncol. 2002;12(2):187–95.PubMedCrossRef
21.
go back to reference Smalley SR, Gunderson L, Tepper J, et al. Gastric surgical adjuvant radiotherapy consensus report: rationale and treatment implementation. Int J Radiat Oncol Biol Phys. 2002;52(2):283–93.PubMedCrossRef Smalley SR, Gunderson L, Tepper J, et al. Gastric surgical adjuvant radiotherapy consensus report: rationale and treatment implementation. Int J Radiat Oncol Biol Phys. 2002;52(2):283–93.PubMedCrossRef
22.
go back to reference Leong T, Willis D, Joon DL, et al. 3D conformal radiotherapy for gastric cancer—results of a comparative planning study. Radiother Oncol. 2005;74(3):301–6.PubMedCrossRef Leong T, Willis D, Joon DL, et al. 3D conformal radiotherapy for gastric cancer—results of a comparative planning study. Radiother Oncol. 2005;74(3):301–6.PubMedCrossRef
24.
go back to reference Dawson LA, Normolle D, Balter JM, et al. Analysis of radiation-induced liver disease using the Lyman NTCP model. Int J Radiat Oncol Biol Phys. 2002;53(4):810–21.PubMedCrossRef Dawson LA, Normolle D, Balter JM, et al. Analysis of radiation-induced liver disease using the Lyman NTCP model. Int J Radiat Oncol Biol Phys. 2002;53(4):810–21.PubMedCrossRef
25.
go back to reference Liang SX, Zhu XD, Xu ZY, et al. Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: the risk factors and hepatic radiation tolerance. Int J Radiat Oncol Biol Phys. 2006;65(2):426–34.PubMedCrossRef Liang SX, Zhu XD, Xu ZY, et al. Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: the risk factors and hepatic radiation tolerance. Int J Radiat Oncol Biol Phys. 2006;65(2):426–34.PubMedCrossRef
26.
go back to reference Kuo YC, Chiu YM, Shih WP, et al. Volumetric intensity-modulated Arc (RapidArc) therapy for primary hepatocellular carcinoma: comparison with intensity-modulated radiotherapy and 3-D conformal radiotherapy. Radiat Oncol. 2011;6:76.PubMedPubMedCentralCrossRef Kuo YC, Chiu YM, Shih WP, et al. Volumetric intensity-modulated Arc (RapidArc) therapy for primary hepatocellular carcinoma: comparison with intensity-modulated radiotherapy and 3-D conformal radiotherapy. Radiat Oncol. 2011;6:76.PubMedPubMedCentralCrossRef
27.
go back to reference Ringash J, Perkins G, Brierley J, et al. IMRT for adjuvant radiation in gastric cancer: a preferred plan? Int J Radiat Oncol Biol Phys. 2005;63(3):732–8.PubMedCrossRef Ringash J, Perkins G, Brierley J, et al. IMRT for adjuvant radiation in gastric cancer: a preferred plan? Int J Radiat Oncol Biol Phys. 2005;63(3):732–8.PubMedCrossRef
28.
go back to reference Minn AY, Hsu A, La T, et al. Comparison of intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy as adjuvant therapy for gastric cancer. Cancer. 2010;116(16):3943–52.PubMedCrossRef Minn AY, Hsu A, La T, et al. Comparison of intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy as adjuvant therapy for gastric cancer. Cancer. 2010;116(16):3943–52.PubMedCrossRef
29.
go back to reference Binny D, Lancaster CM, Harris S, et al. Effects of changing modulation and pitch parameters on tomotherapy delivery quality assurance plans. J Appl Clin Med Phys. 2015;16(5):5282.CrossRef Binny D, Lancaster CM, Harris S, et al. Effects of changing modulation and pitch parameters on tomotherapy delivery quality assurance plans. J Appl Clin Med Phys. 2015;16(5):5282.CrossRef
30.
31.
go back to reference Jansen EP, Saunders MP, Boot H, et al. Prospective study on late renal toxicity following postoperative chemoradiotherapy in gastric cancer. Int J Radiat Oncol Biol Phys. 2007;67(3):781–5.PubMedCrossRef Jansen EP, Saunders MP, Boot H, et al. Prospective study on late renal toxicity following postoperative chemoradiotherapy in gastric cancer. Int J Radiat Oncol Biol Phys. 2007;67(3):781–5.PubMedCrossRef
32.
go back to reference Boda-Heggemann J, Hofheinz RD, Weiss C, et al. Combined adjuvant radiochemotherapy with IMRT/XELOX improves outcome with low renal toxicity in gastric cancer. Int J Radiat Oncol Biol Phys. 2009;75(4):1187–95.PubMedCrossRef Boda-Heggemann J, Hofheinz RD, Weiss C, et al. Combined adjuvant radiochemotherapy with IMRT/XELOX improves outcome with low renal toxicity in gastric cancer. Int J Radiat Oncol Biol Phys. 2009;75(4):1187–95.PubMedCrossRef
33.
go back to reference Rong Y, Chen Y, Shang L, et al. Helical tomotherapy with dynamic running-start-stop delivery compared to conventional tomotherapy delivery. Med Phys. 2014;41(5):051709.PubMedCrossRef Rong Y, Chen Y, Shang L, et al. Helical tomotherapy with dynamic running-start-stop delivery compared to conventional tomotherapy delivery. Med Phys. 2014;41(5):051709.PubMedCrossRef
34.
go back to reference Katayama S, Haefner MF, Mohr A, et al. Accelerated tomotherapy delivery with TomoEdge technique. J Appl Clin Med Phys. 2015;16(2):4964.PubMedCrossRef Katayama S, Haefner MF, Mohr A, et al. Accelerated tomotherapy delivery with TomoEdge technique. J Appl Clin Med Phys. 2015;16(2):4964.PubMedCrossRef
35.
go back to reference Fiorino C, Alongi F, Perna L, et al. Dose-volume relationships for acute bowel toxicity in patients treated with pelvic nodal irradiation for prostate cancer. Int J Radiat Oncol Biol Phys. 2009;75(1):29–35.PubMedCrossRef Fiorino C, Alongi F, Perna L, et al. Dose-volume relationships for acute bowel toxicity in patients treated with pelvic nodal irradiation for prostate cancer. Int J Radiat Oncol Biol Phys. 2009;75(1):29–35.PubMedCrossRef
36.
go back to reference Wang X, Tian Y, Tang Y, et al. Tomotherapy as an adjuvant treatment for gastroesophageal junction and stomach cancer may reduce bowel and bone marrow toxicity compared to intensity-modulated radiotherapy and volumetric-modulated arc therapy. Oncotarget. 2017;8(24):39727–35.PubMedPubMedCentral Wang X, Tian Y, Tang Y, et al. Tomotherapy as an adjuvant treatment for gastroesophageal junction and stomach cancer may reduce bowel and bone marrow toxicity compared to intensity-modulated radiotherapy and volumetric-modulated arc therapy. Oncotarget. 2017;8(24):39727–35.PubMedPubMedCentral
37.
go back to reference Wolff D, Stieler F, Welzel G, et al. Volumetric modulated arc therapy (VMAT) vs. serial tomotherapy, step-and-shoot IMRT and 3D-conformal RT for treatment of prostate cancer. Radiother Oncol. 2009;93(2):226–33.PubMedCrossRef Wolff D, Stieler F, Welzel G, et al. Volumetric modulated arc therapy (VMAT) vs. serial tomotherapy, step-and-shoot IMRT and 3D-conformal RT for treatment of prostate cancer. Radiother Oncol. 2009;93(2):226–33.PubMedCrossRef
Metadata
Title
Dosimetric comparison of 3-dimensional conformal radiotherapy, volumetric modulated arc therapy, and helical tomotherapy for postoperative gastric cancer patients
Authors
Cem Onal
Yemliha Dölek
Berna Akkuş Yıldırım
Publication date
01-01-2018
Publisher
Springer Japan
Published in
Japanese Journal of Radiology / Issue 1/2018
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-017-0696-x

Other articles of this Issue 1/2018

Japanese Journal of Radiology 1/2018 Go to the issue