Top

Published in:

01-02-2014 | Original Article

Apparent diffusion coefficient is a prognostic factor of head and neck squamous cell carcinoma treated with radiotherapy

Authors: Masamitsu Hatakenaka, Katsumasa Nakamura, Hidetake Yabuuchi, Yoshiyuki Shioyama, Yoshio Matsuo, Takeshi Kamitani, Masato Yonezawa, Takashi Yoshiura, Torahiko Nakashima, Mitsuru Mori, Hiroshi Honda

Published in: Japanese Journal of Radiology | Issue 2/2014

Abstract

Purpose

To evaluate the correlation between apparent diffusion coefficient (ADC) and prognosis in head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy.

Materials and methods

We retrospectively studied 41 patients (38 male and 3 female, ages 37–85 years) diagnosed with HNSCC (14 oropharynx, 22 hypopharynx, 4 larynx, 1 oral cavity) and treated with radiotherapy, with radiation dose to gross tumor volume over 60 Gy. The association between age, gender, performance status, tumor location, T stage, N stage, stage, dose, overall treatment time, treatment method, adjuvant therapy, or ADC and prognosis was analyzed using a Cox proportional hazard test.

Results

ADC calculated with b-values of 300, 500, 750, and 1,000 s/mm² (ADC 300–1,000) alone showed a significant correlation with all of the analyses (p = 0.022 for local control, p = 0.0109 for regional control, p = 0.0041 for disease-free survival, and p = 0.0014 for overall survival). ADC calculated with b-values of 0, 100, and 200 s/mm² (ADC 0–200) showed a significant correlation with overall survival (p = 0.0012). N stage showed a significant correlation with regional control (p = 0.0241). Performance status showed significant association with local control (p = 0.0459), disease-free survival (p = 0.023), and overall survival (p = 0.0151), respectively.

Conclusion

ADC is an independent predictor of prognosis in HNSCC treated with radiotherapy.

Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer. 2001;94(2):153–6.PubMedCrossRef

Argiris A, Karamouzis MV, Raben D, Ferris RL. Head and neck cancer. Lancet. 2008;371(9625):1695–709.PubMedCrossRef

Tanner JE. Intracellular diffusion of water. Arch Biochem Biophys. 1983;224(2):416–28.PubMedCrossRef

Hatakenaka M, Matsuo Y, Setoguchi T, Yabuuchi H, Okafuji T, Kamitani T, et al. Alteration of proton diffusivity associated with passive muscle extension and contraction. J Magn Reson Imaging. 2008;27(4):932–7.PubMedCrossRef

Mardor Y, Roth Y, Ochershvilli A, Spiegelmann R, Tichler T, Daniels D, et al. Pretreatment prediction of brain tumors’ response to radiation therapy using high b-value diffusion-weighted MRI. Neoplasia. 2004;6(2):136–42.PubMedCentralPubMedCrossRef

Higano S, Yun X, Kumabe T, Watanabe M, Mugikura S, Umetsu A, et al. Malignant astrocytic tumors: clinical importance of apparent diffusion coefficient in prediction of grade and prognosis. Radiology. 2006;241(3):839–46.PubMedCrossRef

Murakami R, Sugahara T, Nakamura H, Hirai T, Kitajima M, Hayashida Y, et al. Malignant supratentorial astrocytoma treated with postoperative radiation therapy: prognostic value of pretreatment quantitative diffusion-weighted MR imaging. Radiology. 2007;243(2):493–9.PubMedCrossRef

Jingu K, Kishimoto R, Mizoe JE, Hasegawa A, Bessho H, Tsuji H, et al. Malignant mucosal melanoma treated with carbon ion radiotherapy with concurrent chemotherapy: prognostic value of pretreatment apparent diffusion coefficient (ADC). Radiother Oncol. 2011;98(1):68–73.PubMedCrossRef

Chenevert TL, Stegman LD, Taylor JM, Robertson PL, Greenberg HS, Rehemtulla A, et al. Diffusion magnetic resonance imaging: an early surrogate marker of therapeutic efficacy in brain tumors. J Natl Cancer Inst. 2000;92(24):2029–36.PubMedCrossRef

10.

Hamstra DA, Chenevert TL, Moffat BA, Johnson TD, Meyer CR, Mukherji SK, et al. Evaluation of the functional diffusion map as an early biomarker of time-to-progression and overall survival in high-grade glioma. Proc Natl Acad Sci USA. 2005;102(46):16759–64.PubMedCrossRef

11.

Koh DM, Scurr E, Collins D, Kanber B, Norman A, Leach MO, et al. Predicting response of colorectal hepatic metastasis: value of pretreatment apparent diffusion coefficients. Am J Roentgenol. 2007;188(4):1001–8.CrossRef

12.

Mardor Y, Pfeffer R, Spiegelmann R, Roth Y, Maier SE, Nissim O, et al. Early detection of response to radiation therapy in patients with brain malignancies using conventional and high b-value diffusion-weighted magnetic resonance imaging. J Clin Oncol. 2003;21(6):1094–100.PubMedCrossRef

13.

Moffat BA, Chenevert TL, Lawrence TS, Meyer CR, Johnson TD, Dong Q, et al. Functional diffusion map: a noninvasive MRI biomarker for early stratification of clinical brain tumor response. Proc Natl Acad Sci USA. 2005;102(15):5524–9.PubMedCrossRef

14.

Kato H, Kanematsu M, Tanaka O, Mizuta K, Aoki M, Shibata T, et al. Head and neck squamous cell carcinoma: usefulness of diffusion-weighted MR imaging in the prediction of a neoadjuvant therapeutic effect. Eur Radiol. 2009;19(1):103–9.PubMedCrossRef

15.

Kim S, Loevner L, Quon H, Sherman E, Weinstein G, Kilger A, et al. Diffusion-weighted magnetic resonance imaging for predicting and detecting early response to chemoradiation therapy of squamous cell carcinomas of the head and neck. Clin Cancer Res. 2009;15(3):986–94.PubMedCentralPubMedCrossRef

16.

Galban CJ, Mukherji SK, Chenevert TL, Meyer CR, Hamstra DA, Bland PH, et al. A feasibility study of parametric response map analysis of diffusion-weighted magnetic resonance imaging scans of head and neck cancer patients for providing early detection of therapeutic efficacy. Transl Oncol. 2009;2(3):184–90.PubMedCentralPubMed

17.

Hatakenaka M, Nakamura K, Yabuuchi H, Shioyama Y, Matsuo Y, Ohnishi K, et al. Pretreatment apparent diffusion coefficient of the primary lesion correlates with local failure in head-and-neck cancer treated with chemoradiotherapy or radiotherapy. Int J Radiat Oncol Biol Phys. 2011;81(2):339–45.PubMedCrossRef

18.

Hatakenaka M, Shioyama Y, Nakamura K, Yabuuchi H, Matsuo Y, Sunami S, et al. Apparent diffusion coefficient calculated with relatively high b-values correlates with local failure of head and neck squamous cell carcinoma treated with radiotherapy. Am J Neuroradiol. 2011;32(10):1904–10.PubMedCrossRef

19.

Vandecaveye V, Dirix P, De Keyzer F, Op de Beeck K, Vander Poorten V, Hauben E, et al. Diffusion-weighted magnetic resonance imaging early after chemoradiotherapy to monitor treatment response in head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2012;82(3):1098–107.PubMedCrossRef

20.

Hauser T, Essig M, Jensen A, Gerigk L, Laun FB, Munter M, et al. Characterization and therapy monitoring of head and neck carcinomas using diffusion-imaging-based intravoxel incoherent motion parameters—preliminary results. Neuroradiology. 2013;55(5):527–36.PubMedCrossRef

21.

Ohnishi K, Shioyama Y, Hatakenaka M, Nakamura K, Abe K, Yoshiura T, et al. Prediction of local failures with a combination of pretreatment tumor volume and apparent diffusion coefficient in patients treated with definitive radiotherapy for hypopharyngeal or oropharyngeal squamous cell carcinoma. J Radiat Res. 2011;52(4):522–30.PubMedCrossRef

22.

Hatakenaka M, Shonai T, Aratani K, Onodera M, Nakamura K, Yabuuchi H, et al. The calculation method of ADC affects the correlation between prognosis and ADC (in Japanese). Jpn J Magn Reson Med. 2012;32(Supplement):327. http://www.jsmrm.jp/modules/en/index.php?content_id=1.

23.

Hatakenaka M, Soeda H, Yabuuchi H, Matsuo Y, Kamitani T, Oda Y, et al. Apparent diffusion coefficients of breast tumors: clinical application. Magn Reson Med Sci. 2008;7(1):23–9.PubMedCrossRef

24.

Rzeszowska-Wolny J, Przybyszewski WM, Widel M. Ionizing radiation-induced bystander effects, potential targets for modulation of radiotherapy. Eur J Pharmacol. 2009;625(1–3):156–64.PubMedCrossRef

25.

Le Bihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M. Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology. 1988;168(2):497–505.PubMed

26.

Yamada I, Aung W, Himeno Y, Nakagawa T, Shibuya H. Diffusion coefficients in abdominal organs and hepatic lesions: evaluation with intravoxel incoherent motion echo-planar MR imaging. Radiology. 1999;210(3):617–23.PubMedCrossRef

27.

Oppo K, Leen E, Angerson WJ, Cooke TG, McArdle CS. Doppler perfusion index: an interobserver and intraobserver reproducibility study. Radiology. 1998;208(2):453–7.PubMed

28.

Bou-Assaly W, Srinivasan A, Mukherji SK. Head and neck high-field imaging: oncology applications. Neuroimaging Clin N Am. 2012;22(2):285–96 (xi).PubMedCrossRef

Title: Apparent diffusion coefficient is a prognostic factor of head and neck squamous cell carcinoma treated with radiotherapy
Authors: Masamitsu Hatakenaka
Katsumasa Nakamura
Hidetake Yabuuchi
Yoshiyuki Shioyama
Yoshio Matsuo
Takeshi Kamitani
Masato Yonezawa
Takashi Yoshiura
Torahiko Nakashima
Mitsuru Mori
Hiroshi Honda
Publication date: 01-02-2014
Publisher: Springer Japan
Published in: Japanese Journal of Radiology / Issue 2/2014
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-013-0272-y

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Apparent diffusion coefficient is a prognostic factor of head and neck squamous cell carcinoma treated with radiotherapy

Abstract

Purpose

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 2/2014

Chronic contained rupture of abdominal aortic aneurysm (CCR-AAA) with massive vertebral bone erosion: computed tomography (CT), magnetic resonance imaging (MRI) and fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) findings

Percutaneous transluminal angioplasty of a non-mainstream venous route to restore an occluded hemodialysis fistula

Prevalence and clinical significance of incidental F18-FDG breast uptake: a systematic review and meta-analysis

Sesamoiditis of the cyamella: imaging features of this rare presentation

Diffusional kurtosis imaging analysis in patients with hypertension

Hemodynamics and progression of a hypervascular focus in a borderline lesion of hepatocellular carcinoma: analysis by angiography-assisted CT and histopathology