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International Journal of Mental Health and Addiction

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Open Access 01-10-2021 | Suicide | Original Article

Impulsivity and Impulsivity-Related Endophenotypes in Suicidal Patients with Substance Use Disorders: an Exploratory Study

Authors: Alessandra Costanza, Stéphane Rothen, Sophia Achab, Gabriel Thorens, Marc Baertschi, Kerstin Weber, Alessandra Canuto, Hélène Richard-Lepouriel, Nader Perroud, Daniele Zullino

Published in: International Journal of Mental Health and Addiction | Issue 5/2021

Abstract

Suicidal behavior (SB) is a major problem in patients with substance use disorders (SUDs). However, little is known about specific SB risk factors in this population, and pathogenetic hypotheses are difficult to disentangle. This study investigated some SB and SUD-related endophenotypes, such as impulsivity, aggression, trait anger, and risk-taking behaviors (RTBs), in forty-eight patients with SUDs in relation to lifetime history of suicide attempts (SAs). Disorders related to alcohol, cannabis, cocaine, opiates, and hallucinogenic drugs were included. Lifetime SAs was significantly associated with both higher impulsivity and higher aggression, but not with trait anger. A higher number of RTBs were associated with lifetime SAs and higher impulsivity, but not with aggression and trait anger. Assessing these endophenotypes could refine clinical SB risk evaluation in SUDs patients by detecting higher-risk subgroups. An important limitation of this study is exiguity of its sample size. Its primary contribution is inclusion of all SUD types.

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Title: Impulsivity and Impulsivity-Related Endophenotypes in Suicidal Patients with Substance Use Disorders: an Exploratory Study
Authors: Alessandra Costanza
Stéphane Rothen
Sophia Achab
Gabriel Thorens
Marc Baertschi
Kerstin Weber
Alessandra Canuto
Hélène Richard-Lepouriel
Nader Perroud
Daniele Zullino
Publication date: 01-10-2021
Publisher: Springer US
Keywords: Suicide
Suicide
Published in: International Journal of Mental Health and Addiction / Issue 5/2021
Print ISSN: 1557-1874
Electronic ISSN: 1557-1882
DOI: https://doi.org/10.1007/s11469-020-00259-3

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Impulsivity and Impulsivity-Related Endophenotypes in Suicidal Patients with Substance Use Disorders: an Exploratory Study

Abstract

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Abstract

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