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Published in: HSS Journal ® 2/2019

01-07-2019 | Original Article

Pediatric Septic Arthritis and Osteomyelitis in the USA: A National KID Database Analysis

Authors: Gabriella Safdieh, MS, MD, Jason Silberman, BA, Joseph Nguyen, MPH, Shevaun M. Doyle, MD, John S. Blanco, MD, David M. Scher, MD, Daniel W. Green, MD, MS, Roger F. Widmann, MD, Emily R. Dodwell, MD, MPH, FRCSC

Published in: HSS Journal ® | Issue 2/2019

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Abstract

Background

Prior reports suggest that osteoarticular infections may be increasing over time.

Questions/Purposes

We sought to determine if incidence rates, median in-hospital costs, and length of stay (LOS) of osteomyelitis, septic arthritis (SA), and combined infections have changed over time for pediatric patients, and how they compare to previously reported rates.

Methods

The Kids’ Inpatient Database (KID), a US national sample of pediatric hospital discharge records from 1997, 2000, 2003, 2006, 2009, and 2012, was used to determine yearly estimated counts of infections in children 20 years of age or younger. US census data was used to calculate yearly incidence rates. Trend tests using linear contrast analysis were used to compare estimated median LOS and inflation-adjusted median costs over time for each type of infection.

Results

From 1997 through 2012, the incidence rate of osteomyelitis increased from 7.9 to 10.5 per 100,000, SA was unchanged from 5.3 to 5.2 per 100, and combined infections increased from 0.8 to 1.3 per 100,000. Median LOS from 1997 to 2012 showed no significant change for osteomyelitis (5.0 to 4.9 days), SA (4.4 to 4.1 days), or combined infections (6.5 to 6.8 days). Median in-hospital costs from 1997 to 2012 increased for osteomyelitis ($7735 to $11,823), SA ($5041 to $10,574), and combined infections ($12,691 to $16,260).

Conclusion

In pediatric patients, the estimated incidence rate of SA appeared stable, while rates of osteomyelitis and combined infections increased. These estimated rates fall within previously reported ranges. Despite stable LOS, costs have increased over time.
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Literature
2.
go back to reference Arnold SR, Elias D, Buckingham SC, et al. Changing patterns of acute hematogenous osteomyelitis and septic arthritis: emergence of community-associated methicillin-resistant Staphylococcus aureus. J Pediatr Orthop. 2006;26(6):703–708.CrossRefPubMed Arnold SR, Elias D, Buckingham SC, et al. Changing patterns of acute hematogenous osteomyelitis and septic arthritis: emergence of community-associated methicillin-resistant Staphylococcus aureus. J Pediatr Orthop. 2006;26(6):703–708.CrossRefPubMed
3.
go back to reference Arnold JC, Cannavino CR, Ross MK, et al. Acute bacterial osteoarticular infections: eight-year analysis of C-reactive protein for oral step-down therapy. Pediatrics. 2012;130(4):e821–8.CrossRefPubMed Arnold JC, Cannavino CR, Ross MK, et al. Acute bacterial osteoarticular infections: eight-year analysis of C-reactive protein for oral step-down therapy. Pediatrics. 2012;130(4):e821–8.CrossRefPubMed
4.
go back to reference Benvenuti M, An T, Amaro E, et al. Double-edged sword: musculoskeletal infection provoked acute phase response in children. Orthop Clin N Am. 2017;48(2):181–197.CrossRef Benvenuti M, An T, Amaro E, et al. Double-edged sword: musculoskeletal infection provoked acute phase response in children. Orthop Clin N Am. 2017;48(2):181–197.CrossRef
5.
go back to reference Chou ACC, Mahadev A. The use of C-reactive protein as a guide for transitioning to oral antibiotics in pediatric osteoarticular infections. J Pediatr Orthop. 2016;36(2):173–177.CrossRefPubMed Chou ACC, Mahadev A. The use of C-reactive protein as a guide for transitioning to oral antibiotics in pediatric osteoarticular infections. J Pediatr Orthop. 2016;36(2):173–177.CrossRefPubMed
6.
go back to reference Cohen E, Lifshitz K, Fruchtman Y, Eidelman M, Leibovitz E. Current data on acute haematogenous osteomyelitis in children in Southern Israel: epidemiology, microbiology, clinics and therapeutic consequences. Int Orthop. 2016;40(9):1987–1994.CrossRefPubMed Cohen E, Lifshitz K, Fruchtman Y, Eidelman M, Leibovitz E. Current data on acute haematogenous osteomyelitis in children in Southern Israel: epidemiology, microbiology, clinics and therapeutic consequences. Int Orthop. 2016;40(9):1987–1994.CrossRefPubMed
8.
go back to reference Dagan R. Management of acute hematogenous osteomyelitis and septic arthritis in the pediatric patient. Pediatr Infect Dis J. 1993;12(1):88–92.CrossRefPubMed Dagan R. Management of acute hematogenous osteomyelitis and septic arthritis in the pediatric patient. Pediatr Infect Dis J. 1993;12(1):88–92.CrossRefPubMed
9.
go back to reference Dartnell J, Ramachandran M, Katchburian M. Haematogenous acute and subacute paediatric osteomyelitis: a systematic review of the literature. J Bone Joint Surg Br. 2012;94(5):584–595. Dartnell J, Ramachandran M, Katchburian M. Haematogenous acute and subacute paediatric osteomyelitis: a systematic review of the literature. J Bone Joint Surg Br. 2012;94(5):584–595.
10.
go back to reference de Kraker MEA, Wolkewitz M, Davey PG, et al. Clinical impact of antimicrobial resistance in European hospitals: excess mortality and length of hospital stay related to methicillin-resistant Staphylococcus aureus bloodstream infections. Antimicrob Agents Chemother. 2011;55(4):1598–1605.CrossRefPubMedPubMedCentral de Kraker MEA, Wolkewitz M, Davey PG, et al. Clinical impact of antimicrobial resistance in European hospitals: excess mortality and length of hospital stay related to methicillin-resistant Staphylococcus aureus bloodstream infections. Antimicrob Agents Chemother. 2011;55(4):1598–1605.CrossRefPubMedPubMedCentral
11.
go back to reference Dodwell ER. Osteomyelitis and septic arthritis in children: current concepts. Curr Opin Pediatr. 2013;25(1). Dodwell ER. Osteomyelitis and septic arthritis in children: current concepts. Curr Opin Pediatr. 2013;25(1).
12.
go back to reference Freedman J, Guller U, Benjamin DK, et al. National trends in health care utilization and racial and socioeconomic disparities in pediatric pyogenic arthritis. J Pediatr Orthop. 2006;26(6):709–715.CrossRefPubMed Freedman J, Guller U, Benjamin DK, et al. National trends in health care utilization and racial and socioeconomic disparities in pediatric pyogenic arthritis. J Pediatr Orthop. 2006;26(6):709–715.CrossRefPubMed
13.
go back to reference Gafur OA, Copley LAB, Hollmig ST, Browne RH, Thornton LA, Crawford SE. The impact of the current epidemiology of pediatric musculoskeletal infection on evaluation and treatment guidelines. J Pediatr Orthop. 2008;28(7):777–785.CrossRefPubMed Gafur OA, Copley LAB, Hollmig ST, Browne RH, Thornton LA, Crawford SE. The impact of the current epidemiology of pediatric musculoskeletal infection on evaluation and treatment guidelines. J Pediatr Orthop. 2008;28(7):777–785.CrossRefPubMed
14.
go back to reference Geirsson AJ, Statkevicius S, Vikingsson A. Septic arthritis in Iceland 1990–2002: increasing incidence due to iatrogenic infections. Ann Rheum Dis. 2008;67(5):638–643.CrossRefPubMed Geirsson AJ, Statkevicius S, Vikingsson A. Septic arthritis in Iceland 1990–2002: increasing incidence due to iatrogenic infections. Ann Rheum Dis. 2008;67(5):638–643.CrossRefPubMed
15.
go back to reference Gillespie WJ. The epidemiology of acute haematogenous osteomyelitis of childhood. Int J Epidemiol. 1985;14(4):600–606.CrossRefPubMed Gillespie WJ. The epidemiology of acute haematogenous osteomyelitis of childhood. Int J Epidemiol. 1985;14(4):600–606.CrossRefPubMed
16.
go back to reference Gillespie WJ. Epidemiology in bone and joint infection. Infect Dis Clin N Am. 1990;4(3):361–376. Gillespie WJ. Epidemiology in bone and joint infection. Infect Dis Clin N Am. 1990;4(3):361–376.
17.
go back to reference Goergens ED, McEvoy A, Watson M, Barrett IR. Acute osteomyelitis and septic arthritis in children. J Paediatr Child Health. 41(1–2):59–62. Goergens ED, McEvoy A, Watson M, Barrett IR. Acute osteomyelitis and septic arthritis in children. J Paediatr Child Health. 41(1–2):59–62.
18.
go back to reference Hawkshead JJ, Patel NB, Steele RW, Heinrich SD. Comparative severity of pediatric osteomyelitis attributable to methicillin-resistant versus methicillin-sensitive Staphylococcus aureus. J Pediatr Orthop. 29(1):85–90. Hawkshead JJ, Patel NB, Steele RW, Heinrich SD. Comparative severity of pediatric osteomyelitis attributable to methicillin-resistant versus methicillin-sensitive Staphylococcus aureus. J Pediatr Orthop. 29(1):85–90.
19.
go back to reference Ilharreborde B. Sequelae of pediatric osteoarticular infection. Orthop Traumatol Surg Res. 2015;101(1):S129–S137.CrossRefPubMed Ilharreborde B. Sequelae of pediatric osteoarticular infection. Orthop Traumatol Surg Res. 2015;101(1):S129–S137.CrossRefPubMed
20.
go back to reference Jagodzinski NA, Kanwar R, Graham K, Bache CE. Prospective evaluation of a shortened regimen of treatment for acute osteomyelitis and septic arthritis in children. J Pediatr Orthop. 2009;29(5):518–525.CrossRefPubMed Jagodzinski NA, Kanwar R, Graham K, Bache CE. Prospective evaluation of a shortened regimen of treatment for acute osteomyelitis and septic arthritis in children. J Pediatr Orthop. 2009;29(5):518–525.CrossRefPubMed
21.
go back to reference Lee GE, Lorch SA, Sheffler-Collins S, Kronman MP, Shah SS. National hospitalization trends for pediatric pneumonia and associated complications. Pediatrics. 2010;126(2):204–213.CrossRefPubMedPubMedCentral Lee GE, Lorch SA, Sheffler-Collins S, Kronman MP, Shah SS. National hospitalization trends for pediatric pneumonia and associated complications. Pediatrics. 2010;126(2):204–213.CrossRefPubMedPubMedCentral
22.
go back to reference Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary. Clin Infect Dis. 2011;52(3):285–292.CrossRefPubMed Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary. Clin Infect Dis. 2011;52(3):285–292.CrossRefPubMed
23.
go back to reference Malcius D, Trumpulyte G, Barauskas V, Kilda A. Two decades of acute hematogenous osteomyelitis in children: are there any changes?. Pediatr Surg Int. 2005;21(5):356–359.CrossRefPubMed Malcius D, Trumpulyte G, Barauskas V, Kilda A. Two decades of acute hematogenous osteomyelitis in children: are there any changes?. Pediatr Surg Int. 2005;21(5):356–359.CrossRefPubMed
24.
go back to reference Monsalve J, Kan JH, Schallert EK, Bisset GS, Zhang W, Rosenfeld SB. Septic arthritis in children: frequency of coexisting unsuspected osteomyelitis and implications on imaging work-up and management. Am J Roentgenol. 2015;204(6):1289–1295.CrossRef Monsalve J, Kan JH, Schallert EK, Bisset GS, Zhang W, Rosenfeld SB. Septic arthritis in children: frequency of coexisting unsuspected osteomyelitis and implications on imaging work-up and management. Am J Roentgenol. 2015;204(6):1289–1295.CrossRef
25.
go back to reference Murillo O, Grau I, Lora-Tamayo J, et al. The changing epidemiology of bacteraemic osteoarticular infections in the early 21st century. Clin Microbiol Infect. 2015;21(3):254.e1–8.CrossRef Murillo O, Grau I, Lora-Tamayo J, et al. The changing epidemiology of bacteraemic osteoarticular infections in the early 21st century. Clin Microbiol Infect. 2015;21(3):254.e1–8.CrossRef
26.
go back to reference Nathwani D. Impact of methicillin-resistant Staphylococcus aureus infections on key health economic outcomes: does reducing the length of hospital stay matter? J Antimicrob Chemother. 2003;51 Suppl 2:ii37–44.PubMed Nathwani D. Impact of methicillin-resistant Staphylococcus aureus infections on key health economic outcomes: does reducing the length of hospital stay matter? J Antimicrob Chemother. 2003;51 Suppl 2:ii37–44.PubMed
27.
go back to reference Nelson JD. The bacterial etiology and antibiotic management of septic arthritis in infants and children. Pediatrics. 1972;50(3):437–440. Nelson JD. The bacterial etiology and antibiotic management of septic arthritis in infants and children. Pediatrics. 1972;50(3):437–440.
29.
go back to reference Paakkonen M, Peltola H. Treatment of acute septic arthritis. Pediatr Infect Dis J. 2013;32(6):684–685.CrossRefPubMed Paakkonen M, Peltola H. Treatment of acute septic arthritis. Pediatr Infect Dis J. 2013;32(6):684–685.CrossRefPubMed
30.
go back to reference Peltola H, Pääkkönen M, Kallio P, Kallio MJT, Osteomyelitis-Septic Arthritis (OM-SA) Study Group. Prospective, randomized trial of 10 days versus 30 days of antimicrobial treatment, including a short-term course of parenteral therapy, for childhood septic arthritis. Clin Infect Dis. 2009;48(9):1201–1210.CrossRefPubMed Peltola H, Pääkkönen M, Kallio P, Kallio MJT, Osteomyelitis-Septic Arthritis (OM-SA) Study Group. Prospective, randomized trial of 10 days versus 30 days of antimicrobial treatment, including a short-term course of parenteral therapy, for childhood septic arthritis. Clin Infect Dis. 2009;48(9):1201–1210.CrossRefPubMed
31.
go back to reference Peltola H, Pääkkönen M, Kallio P, Kallio MJT, Osteomyelitis-Septic Arthritis Study Group. Short- versus long-term antimicrobial treatment for acute hematogenous osteomyelitis of childhood. Pediatr Infect Dis J. 2010;29(12):1123–1128.CrossRefPubMed Peltola H, Pääkkönen M, Kallio P, Kallio MJT, Osteomyelitis-Septic Arthritis Study Group. Short- versus long-term antimicrobial treatment for acute hematogenous osteomyelitis of childhood. Pediatr Infect Dis J. 2010;29(12):1123–1128.CrossRefPubMed
32.
go back to reference Pendleton A, Kocher MS. Methicillin-resistant Staphylococcus aureus bone and joint infections in children. J Am Acad Orthop Surg. 2015;23(1):29–37.CrossRefPubMed Pendleton A, Kocher MS. Methicillin-resistant Staphylococcus aureus bone and joint infections in children. J Am Acad Orthop Surg. 2015;23(1):29–37.CrossRefPubMed
33.
go back to reference Riise OR, Kirkhus E, Handeland KS, et al. Childhood osteomyelitis-incidence and differentiation from other acute onset musculoskeletal features in a population-based study. BMC Pediatr. 2008;8:45.CrossRefPubMedPubMedCentral Riise OR, Kirkhus E, Handeland KS, et al. Childhood osteomyelitis-incidence and differentiation from other acute onset musculoskeletal features in a population-based study. BMC Pediatr. 2008;8:45.CrossRefPubMedPubMedCentral
34.
35.
go back to reference Sarkissian EJ, Gans I, Gunderson MA, Myers SH, Spiegel DA, Flynn JM. Community-acquired methicillin-resistant Staphylococcus aureus musculoskeletal infections: emerging trends over the past decade. J Pediatr Orthop. 36(3):323–327. Sarkissian EJ, Gans I, Gunderson MA, Myers SH, Spiegel DA, Flynn JM. Community-acquired methicillin-resistant Staphylococcus aureus musculoskeletal infections: emerging trends over the past decade. J Pediatr Orthop. 36(3):323–327.
36.
go back to reference Schaub RL, Rodkey ML. Deep vein thrombosis and septic pulmonary emboli with MRSA osteomyelitis in a pediatric patient. Pediatr Emerg Care. 2012;28(9):911–912.CrossRefPubMed Schaub RL, Rodkey ML. Deep vein thrombosis and septic pulmonary emboli with MRSA osteomyelitis in a pediatric patient. Pediatr Emerg Care. 2012;28(9):911–912.CrossRefPubMed
37.
go back to reference Simon TD, Berry J, Feudtner C, et al. Children with complex chronic conditions in inpatient hospital settings in the United States. Pediatrics. 2010;126(4):647–655.CrossRefPubMedPubMedCentral Simon TD, Berry J, Feudtner C, et al. Children with complex chronic conditions in inpatient hospital settings in the United States. Pediatrics. 2010;126(4):647–655.CrossRefPubMedPubMedCentral
38.
go back to reference Stockmann C, Ampofo K, Pavia AT, et al. National trends in the incidence, outcomes and charges of pediatric osteoarticular infections, 1997–2012. Pediatr Infect Dis J. 2015;34(6):672–674.CrossRefPubMed Stockmann C, Ampofo K, Pavia AT, et al. National trends in the incidence, outcomes and charges of pediatric osteoarticular infections, 1997–2012. Pediatr Infect Dis J. 2015;34(6):672–674.CrossRefPubMed
39.
go back to reference U.S. Department of Health and Human Services; Centers for Disease Control and Prevention; National Center for Health Statistics. Bridged-Race Population Estimates, United States July 1st Resident Population by State, County, Age, Sex, Bridged-Race, and Hispanic Origin. Compiled from 1990–1999 Bridged-Race Intercensal Population Estimates; 2004. Available from http://wonder.cdc.gov/bridged-race-v2014.html. U.S. Department of Health and Human Services; Centers for Disease Control and Prevention; National Center for Health Statistics. Bridged-Race Population Estimates, United States July 1st Resident Population by State, County, Age, Sex, Bridged-Race, and Hispanic Origin. Compiled from 1990–1999 Bridged-Race Intercensal Population Estimates; 2004. Available from http://​wonder.​cdc.​gov/​bridged-race-v2014.​html.
40.
go back to reference U.S. Department of Health and Human Services; Centers for Disease Control and Prevention; National Center for Health Statistics. Bridged-Race Population Estimates, United States July 1st Resident Population by State, County, Age, Sex, Bridged-Race, and Hispanic Origin. Revised Bridged-Race 2000–2009 Intercensal Population Estimates; 2012. Available from http://wonder.cdc.gov/bridged-race-v2014.html. U.S. Department of Health and Human Services; Centers for Disease Control and Prevention; National Center for Health Statistics. Bridged-Race Population Estimates, United States July 1st Resident Population by State, County, Age, Sex, Bridged-Race, and Hispanic Origin. Revised Bridged-Race 2000–2009 Intercensal Population Estimates; 2012. Available from http://​wonder.​cdc.​gov/​bridged-race-v2014.​html.
41.
go back to reference U.S. Department of Health and Human Services; Centers for Disease Control and Prevention; National Center for Health Statistics. Intercensal Estimates of the Resident Population of the United States for July 1, 2000–July 1, 2009, by Year, County, Single-Year of Age (0, 1, 2, .., 85 Years and over), Bridged Race, Hispanic Origin, and Sex; 2012. Available from http://www.cdc.gov/nchs/nvss/bridged_race.htm. U.S. Department of Health and Human Services; Centers for Disease Control and Prevention; National Center for Health Statistics. Intercensal Estimates of the Resident Population of the United States for July 1, 2000–July 1, 2009, by Year, County, Single-Year of Age (0, 1, 2, .., 85 Years and over), Bridged Race, Hispanic Origin, and Sex; 2012. Available from http://​www.​cdc.​gov/​nchs/​nvss/​bridged_​race.​htm.
42.
go back to reference U.S. Department of Health and Human Services; Centers for Disease Control and Prevention; National Center for Health Statistics. Bridged-Race Population Estimates, United States July 1st Resident Population by State, County, Age, Sex, Bridged-Race, and Hispanic Origin. Bridged-Race Vintage 2014 (2010–2014) Postcensal Population Estimates; 2015. Available from https://wonder.cdc.gov/bridged-race-v2017.html. U.S. Department of Health and Human Services; Centers for Disease Control and Prevention; National Center for Health Statistics. Bridged-Race Population Estimates, United States July 1st Resident Population by State, County, Age, Sex, Bridged-Race, and Hispanic Origin. Bridged-Race Vintage 2014 (2010–2014) Postcensal Population Estimates; 2015. Available from https://​wonder.​cdc.​gov/​bridged-race-v2017.​html.
43.
go back to reference Vander Have KL, Karmazyn B, Verma M, et al. Community-associated methicillin-resistant Staphylococcus aureus in acute musculoskeletal infection in children: a game changer. J Pediatr Orthop. 2009;29(8):927–931.CrossRefPubMed Vander Have KL, Karmazyn B, Verma M, et al. Community-associated methicillin-resistant Staphylococcus aureus in acute musculoskeletal infection in children: a game changer. J Pediatr Orthop. 2009;29(8):927–931.CrossRefPubMed
44.
go back to reference Welkon CJ, Long SS, Fisher MC, Alburger PD. Pyogenic arthritis in infants and children: a review of 95 cases. Pediatr Infect Dis. 1986;5(6):669–676.CrossRefPubMed Welkon CJ, Long SS, Fisher MC, Alburger PD. Pyogenic arthritis in infants and children: a review of 95 cases. Pediatr Infect Dis. 1986;5(6):669–676.CrossRefPubMed
Metadata
Title
Pediatric Septic Arthritis and Osteomyelitis in the USA: A National KID Database Analysis
Authors
Gabriella Safdieh, MS, MD
Jason Silberman, BA
Joseph Nguyen, MPH
Shevaun M. Doyle, MD
John S. Blanco, MD
David M. Scher, MD
Daniel W. Green, MD, MS
Roger F. Widmann, MD
Emily R. Dodwell, MD, MPH, FRCSC
Publication date
01-07-2019
Publisher
Springer US
Published in
HSS Journal ® / Issue 2/2019
Print ISSN: 1556-3316
Electronic ISSN: 1556-3324
DOI
https://doi.org/10.1007/s11420-018-9644-2

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