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01-01-2013 | Short Communication

Cross-reactivities of 41 new amphetamine designer drugs to EMIT^® immunoassays

Authors: Maria Nieddu, Claudia Trignano, Lucia Burrai, Maria Antonietta Pirisi, Gianpiero Boatto

Published in: Forensic Toxicology | Issue 1/2013

Abstract

Amphetamine designer drugs are central nervous system stimulants, and are widely diffused in illegal markets. Monitoring of drugs of abuse in biological fluids is successfully used for clinical and forensic applications. In particular, the urine matrix allows the verification of drug intake in the short and medium term. In a forensic toxicology laboratory, typical analysis for these drugs involves an immunoassay screening method. Here we describe the cross-reactivity profiles of 41 new amphetamine designer drugs to the urine drug tests EMIT^® II Plus (Amphetamines assay and Ecstasy assay).

Accordo, ai sensi dell'articolo 8, comma 2 dell'Intesa in materia di accertamento di assenza di tossicodipendenza, perfezionata nella seduta della Conferenza Unificata del 30 ottobre 2007 (Rep. Atti n. 99/CU), sul documento recante «Procedure per gli accertamenti sanitari di assenza di tossicodipendenza o di assunzione di sostanze stupefacenti o psicotrope in lavoratori addetti a mansioni che comportano particolari rischi per la sicurezza, l’incolumità e la salute di terzi». (Rep. Atti n. 178/CSR). (G.U. Serie Generale n. 236 del 8 ottobre 2008).

The American Heritage^® Medical Dictionary (2004) Houghton Mifflin Company

United Nations Office on Drugs and Crime (2010) World Drug Report 2010. United Nations Publication, New York

Ensslin HK, Kovar KA, Maurer HH (1996) Toxicological detection of the designer drug 3,4-methylenedioxyethylamphetamine (MDE, “Eve”) and its metabolites in urine by GC–MS and fluorescence polarization immunoassay. J Chromatogr B 683:189–197CrossRef

Ortuño J, Pizarro N, Farrè M, Mas M, Segura J, Camì J, Brenneisen R, Torre R (1999) Quantification of 3,4-methylenedioxymethamphetamine and its metabolites in plasma and urine by gas chromatography with nitrogen-phosphorus detection. J Chromatogr B 723:221–232CrossRef

Nieddu M, Boatto G, Sini L, Dessì G (2007) Determination of paramethoxyamphetamine by CE-DAD from urine and plasma samples. J Liq Chromatogr Relat Technol 30:431–438CrossRef

Boatto G, Nieddu M, Pirisi MA, Dessì G (2007) Simultaneous determination of new thioamphetamine designer drugs in plasma by capillary electrophoresis coupled with mass spectrometry. Rapid Commun Mass Spectrom 21:3716–3720PubMedCrossRef

Boatto G, Nieddu M, Dessì G, Manconi P, Cerri R (2007) Determination of four thiophenethylamine designer drugs (2C-T-series) in human plasma by CE-MS. J Chromatogr A 1159:198–202PubMedCrossRef

Nieddu M, Boatto G, Pirisi MA, Dessì G (2010) Determination of four thiophenethylamine designer drugs (2C-T-4, 2C-T-8, 2C-T-13, 2C-T-17) in human urine by CE-MS. Rapid Commun Mass Spectrom 24:2357–2362PubMedCrossRef

Nieddu M, Boatto G, Dessì G (2007) Determination of 4-alkyl 2,5-dimethoxyamphetamine derivatives by CE-MS from urine samples. J Chromatogr B 852:578–581CrossRef

10.

Nieddu M, Boatto G, Pirisi MA, Baralla E (2009) Multi-residue analysis of eight thioamphetamine designer drugs in human urine by LC–MS/MS. Rapid Commun Mass Spectrom 23:3051–3056PubMedCrossRef

11.

Boatto G, Nieddu M, Carta A, Pau A, Palomba M, Asproni B, Cerri R (2005) Determination of amphetamine-derived designer drugs in human urine by SPE extraction and capillary electrophoresis with mass spectrometry detection. J Chromatogr B 814:93–98CrossRef

12.

Nieddu M, Boatto G, Carta A, Sanna A, Pisano M (2005) Simultaneous determination of ten amphetamine designer drugs in human whole blood by capillary electrophoresis with diode array detector. Biomed Chromatogr 19:737–742PubMedCrossRef

13.

Nieddu M, Boatto G, Pirisi MA, Azara E, Marchetti M (2008) LC–MS analysis of trimethoxyamphetamine designer drugs (TMA series) from urine samples. J Chromatogr B 867:126–130CrossRef

14.

Shulgin A (1991) Pihkal, a chemical love story. Transform Press, Berkeley

15.

Nakanishi K, Miki A, Zaitsu K, Kamata H, Shima N, Kamata T, Katagi M, Tatsuno M, Tsuchihashi H, Suzuki K (2012) Cross-reactivities of various phenethylamine-type designer drugs to immunoassays for amphetamines, with special attention to the evaluation of the one-step urine drug test Instant-View™, and the Emit^® assays for use in drug enforcement. Forensic Sci Int 217:174–181PubMedCrossRef

Title: Cross-reactivities of 41 new amphetamine designer drugs to EMIT® immunoassays
Authors: Maria Nieddu
Claudia Trignano
Lucia Burrai
Maria Antonietta Pirisi
Gianpiero Boatto
Publication date: 01-01-2013
Publisher: Springer Japan
Published in: Forensic Toxicology / Issue 1/2013
Print ISSN: 1860-8965
Electronic ISSN: 1860-8973
DOI: https://doi.org/10.1007/s11419-012-0156-3

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Springer Medicine

Cross-reactivities of 41 new amphetamine designer drugs to EMIT^® immunoassays

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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