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Forensic Toxicology
Published in: Forensic Toxicology 1/2013

01-01-2013 | Short Communication

Identification and quantitation of JWH-213, a cannabimimetic indole, as a designer drug in a herbal product

Authors: Kazunaga Takahashi, Nahoko Uchiyama, Tomohide Fukiwake, Takashi Hasegawa, Masaaki Saijou, Yuji Motoki, Ruri Kikura-Hanajiri, Yukihiro Goda

Published in: Forensic Toxicology | Issue 1/2013

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Abstract

In our survey of designer drugs in the Japanese market, a cannabimimetic indole was identified as a new active compound in a herbal product. The structure of this compound was elucidated by liquid chromatography–photodiode array–mass spectrometry (LC–PDA–MS), gas chromatography–mass spectrometry (GC–MS), high-resolution MS, and nuclear magnetic resonance (NMR) analyses. The compound was finally identified as (4-ethyl-1-naphthalenyl)(2-methyl-1-pentyl-1H-indol-3-yl)methanone (JWH-213), an indole-based cannabinoid receptor ligand. To our knowledge, this is the first finding of JWH-213 as a designer drug in a herbal product. The quantitative LC–PDA analysis showed that the JWH-213 content in the product was 252 mg/pack.
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Metadata
Title
Identification and quantitation of JWH-213, a cannabimimetic indole, as a designer drug in a herbal product
Authors
Kazunaga Takahashi
Nahoko Uchiyama
Tomohide Fukiwake
Takashi Hasegawa
Masaaki Saijou
Yuji Motoki
Ruri Kikura-Hanajiri
Yukihiro Goda
Publication date
01-01-2013
Publisher
Springer Japan
Published in
Forensic Toxicology / Issue 1/2013
Print ISSN: 1860-8965
Electronic ISSN: 1860-8973
DOI
https://doi.org/10.1007/s11419-012-0161-6

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