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Published in: Journal of Natural Medicines 4/2020

01-09-2020 | Original Paper

Cytotoxic activities of sesquiterpenoids from the aerial parts of Petasites japonicus against cancer stem cells

Authors: Takahiro Matsumoto, Daisuke Imahori, Youhei Saito, Wei Zhang, Tomoe Ohta, Tatsusada Yoshida, Yuji Nakayama, Eishi Ashihara, Tetsushi Watanabe

Published in: Journal of Natural Medicines | Issue 4/2020

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Abstract

Abstract

From the methanolic extract of the aerial parts of Petasites japonicus, six new eremophilane-type sesquiterpenoids, petasitesterpenes I–VI were isolated together with eight known compounds including S-japonin and eremophilenolide. The chemical structures of the isolated new compounds were elucidated based on chemical/physicochemical evidence. For petasitesterpenes I and II, the absolute configurations were established by comparison of experimental and predicted electronic circular dichroism (ECD) data. Among the isolated compounds, petasitesterpenes I, II, VI, and S-japonin showed cytotoxic activity against both human astrocytoma U-251MG cancer cells (non-CSCs) and their cancer stem cells (CSCs) isolated by sphere formation. In addition, cytotoxic activities of these compounds against breast cancer MDA-MB-231 were evaluated, supporting that petasitesterpene II has more effective than other isolated compounds.

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Metadata
Title
Cytotoxic activities of sesquiterpenoids from the aerial parts of Petasites japonicus against cancer stem cells
Authors
Takahiro Matsumoto
Daisuke Imahori
Youhei Saito
Wei Zhang
Tomoe Ohta
Tatsusada Yoshida
Yuji Nakayama
Eishi Ashihara
Tetsushi Watanabe
Publication date
01-09-2020
Publisher
Springer Singapore
Published in
Journal of Natural Medicines / Issue 4/2020
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-020-01420-x

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