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01-06-2020 | Original Paper

Induction of secondary metabolite production by fungal co-culture of Talaromyces pinophilus and Paraphaeosphaeria sp.

Authors: Shunya Murakami, Nozomu Hayashi, Teruyo Inomata, Hikaru Kato, Yuki Hitora, Sachiko Tsukamoto

Published in: Journal of Natural Medicines | Issue 3/2020

Abstract

Fungal co-culture is a strategy to induce the production of secondary metabolites by activating cryptic genes. We discovered the production of a new compound, talarodone A (1), along with five known compounds 2–6 in co-culture of Talaromyces pinophilus and Paraphaeosphaeria sp. isolated from soil collected in Miyazaki Prefecture, Japan. Among them, the productions of penicidones C (2) and D (3) were enhanced 27- and sixfold, respectively, by the co-culture. The structure of 3 should be represented as a γ-pyridol form with the reported chemical shifts, but not as a γ-pyridone form, based on DFT calculation.

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Title: Induction of secondary metabolite production by fungal co-culture of Talaromyces pinophilus and Paraphaeosphaeria sp.
Authors: Shunya Murakami
Nozomu Hayashi
Teruyo Inomata
Hikaru Kato
Yuki Hitora
Sachiko Tsukamoto
Publication date: 01-06-2020
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 3/2020
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-020-01400-1

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Induction of secondary metabolite production by fungal co-culture of Talaromyces pinophilus and Paraphaeosphaeria sp.

Abstract

Graphic abstract

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Springer Medicine

Abstract

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