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New neolignans from the seeds of Myristica fragrans and their cytotoxic activities

Authors: Parinuch Chumkaew, Theera Srisawat

Published in: Journal of Natural Medicines | Issue 1/2019

Abstract

Three new dihydrobenzofuran neolignans, myticaganal A–C (1–3), along with five known compounds (4–8), were isolated from the seeds of Myristica fragrans. Their structures were elucidated by extensive spectroscopic analysis. In vitro cytotoxic activities of the isolated compounds against three human cancer cell lines (KB, oral cavity; MCF-7, breast cancer; and NCI-H187, small cell lung cancer) were evaluated. Neolignan 3 showed significant cytotoxicity against KB and NCI-H187 cell lines with IC₅₀ values of 5.9 and 6.3 μM, respectively.

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Title: New neolignans from the seeds of Myristica fragrans and their cytotoxic activities
Authors: Parinuch Chumkaew
Theera Srisawat
Publication date: 01-01-2019
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 1/2019
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-018-1246-2

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New neolignans from the seeds of Myristica fragrans and their cytotoxic activities

Abstract

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Abstract

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