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01-07-2017 | Note

Two new antimalarial quassinoid derivatives from the stems of Brucea javanica

Authors: Parinuch Chumkaew, Jaraslak Pechwang, Theera Srisawat

Published in: Journal of Natural Medicines | Issue 3/2017

Abstract

Phytochemical investigation of the stems from Brucea javanica led to the isolation of two new quassinoids, brujavanol C (1) and brujavanol D (2), together with six known compounds (3–8). The chemical structures were elucidated by means of various spectroscopic methods. All the isolated compounds were evaluated for antimalarial activity against Plasmodium falciparum and compounds 6 and 7 exhibited the most potent activity against the K1 strain, with IC₅₀ values of 1.41 and 1.06 μM, respectively.

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Title: Two new antimalarial quassinoid derivatives from the stems of Brucea javanica
Authors: Parinuch Chumkaew
Jaraslak Pechwang
Theera Srisawat
Publication date: 01-07-2017
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 3/2017
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-017-1089-2

At a glance: The STEP trials

Springer Medicine

Two new antimalarial quassinoid derivatives from the stems of Brucea javanica

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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