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01-01-2019 | Note

Two new oleanane derivatives from the fruits of Leonurus japonicus and their cytotoxic activities

Authors: Wenwen Peng, Guanghu Huo, Lixia Zheng, Zhonghua Xiong, Xugen Shi, Dayong Peng

Published in: Journal of Natural Medicines | Issue 1/2019

Abstract

Two new oleanane derivatives, leonuronins A and B (1 and 2), along with three known oleanane triterpenes (3–5) were isolated from the fruits of Leonurus japonicus. Their structures were elucidated on the basis of NMR, MS, IR and UV spectroscopic data. The new compounds were tested for cytotoxic activities against A549 and Hela cancer cell lines. Compounds 1 and 2 exhibited weak cytotoxicity with IC₅₀ values ranging from 6.97 to 18.13 μM.

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Title: Two new oleanane derivatives from the fruits of Leonurus japonicus and their cytotoxic activities
Authors: Wenwen Peng
Guanghu Huo
Lixia Zheng
Zhonghua Xiong
Xugen Shi
Dayong Peng
Publication date: 01-01-2019
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 1/2019
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-018-1244-4

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Springer Medicine

Two new oleanane derivatives from the fruits of Leonurus japonicus and their cytotoxic activities

Abstract

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Springer Medicine

Abstract

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