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01-01-2019 | Original Paper

Seven new resin glycosides from the seeds of Quamoclit × multifida

Authors: Masateru Ono, Maako Azuchi, Misato Ichio, Yuki Jiyoubi, Shuhei Tsutsumi, Shin Yasuda, Ryota Tsuchihasi, Masafumi Okawa, Junei Kinjo, Hitoshi Yoshimitsu, Toshihiro Nohara

Published in: Journal of Natural Medicines | Issue 1/2019

Abstract

Seven new resin glycosides, multifidins III (1)–IX (7), were isolated from the seeds of Quamoclit × multifida (syn. Q. sloteri House) (Convolvulaceae), along with five known glycosides, quamoclinic acid B methyl ester (8), operculin XIII (9), quamoclin I (10), QM-10 (11), and QM-12 (12). Their structures were determined on the basis of spectroscopic data and chemical evidence. These compounds were of two different types, i.e., those with macrolactone structures and those with non-macrolactone structures. Additionally, cytotoxic activity towards HL-60 human leukemia cells of 1, 2, 5, 8, 9, 11, and 12 was evaluated. Among them, macrolactone-type resin glycosides (jalapins), 1, 2, and 9, specifically demonstrated clear cytotoxic activity with IC₅₀ values of 3.46, 14.7, and 10.9 μM, respectively.

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Title: Seven new resin glycosides from the seeds of Quamoclit × multifida
Authors: Masateru Ono
Maako Azuchi
Misato Ichio
Yuki Jiyoubi
Shuhei Tsutsumi
Shin Yasuda
Ryota Tsuchihasi
Masafumi Okawa
Junei Kinjo
Hitoshi Yoshimitsu
Toshihiro Nohara
Publication date: 01-01-2019
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 1/2019
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-018-1236-4

At a glance: The STEP trials

Springer Medicine

Seven new resin glycosides from the seeds of Quamoclit × multifida

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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