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01-07-2017 | Note

Two new secolignans with in vitro anti-inflammatory activities from Urtica fissa rhizomes

Authors: Xiaoru Feng, Mengyue Wang, Jun Cheng, Xiaobo Li

Published in: Journal of Natural Medicines | Issue 3/2017

Abstract

Two new secolignans, urticin A (1) and urticin B (2), were isolated from the ethanol extract of Urtica fissa rhizomes. Their structures were elucidated on the basis of extensive spectroscopic evidence (UV, IR, HR-ESI–MS, and NMR). Urticin A and urticin B possessed in vitro anti-inflammatory activities, which significantly inhibited the TNF-α and NO release induced by LPS in RAW 264.7 cells.

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European Directorate for the Quality Control of Medicines (2016) European Pharmacopoeia 9.0, Strasbourg, pp 1450–1452

British Pharmacopoeia Commission (2015) British Pharmacopoeia (IV), London, p 288

Chen JR, Lin Q, Friis I, Wilmot-Dear, CM, Monro AK (2003) Flora of China, vol 5. Science Press, Beijing, Missouri Botanical Garden Press, St. Louis, pp 78–84

Chinese Materia Medica Editorial Board (1999) Chinese Materia Medica (2). Shanghai Science and Technology Press, Shanghai, pp p584–p585

Zhang JH, Lu HX, Li JZ, Lu XP (2011) Study on chemical constituents from the root of Urtica fissa. J Guangdong Pharm Coll 27:144–146

Ji BQ, Feng BM, Shi LY, Tang L, Wang YQ (2009) Chemical constituents of the roots of Urtica fissa E. Pritz. Chin Pharm J 44:1372–1374

Feng BM, Qin HH, Wang HG, Shi LY, Yu DY, Ji BQ, Zhao Q, Wang YQ (2012) Three new secolignan glycosides from Urtica fissa E. Pritz. J Nat Med 66:562–565CrossRefPubMed

Ji BQ, Yan XG, Duan LX, Tang L, Shi LY, Wang YQ, Feng BM (2009) Two new secolignans from the roots of Urtica fissa E. Pritz. Helv Chim Acta 92:997–1001CrossRef

Wang YL, Li L, Cheng XC, Lu YX, Zhang QL (2012) Structure of a polysaccharide from Urtica fissa determined by NMR spectra. J Asian Nat Prod Res 14:592–595CrossRefPubMed

10.

Li Y, Wang YL, Li L, Liu L, Lu YX, Cheng XC, Zhan QL (2009) Structural characterization of polysaccharides from the roots of Urtica fissa. J Asian Nat Prod Res 11:951–957CrossRefPubMed

11.

Chen XC, He S, Lu YX, Yuan LZ, Ding LM, Yuan SJ, Zhang QL (2015) Inhibition of spontaneous canine benign prostatic hyperplasia by an Urtica fissa polysaccharide fraction. Planta Med 81:10–14

12.

Wu HH, Li ZF, Zhang QH, Pei YH (2010) Application of CD in study of the absolute configuration of lignans. J Shenyang Pharm Univ 27:587–593

13.

Lu X, Zhang WW, Cheng XH, Wang HG, Yu DY, Feng BM (2014) Advances on the secolignans compounds in natural products. J Shenyang Pharm Univ 31:922–926

14.

Inaba K, Murata K, Naruto S, Matsuda H (2010) Inhibitory effects of devil’s claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages. J Nat Med 64:219–222CrossRefPubMed

Title: Two new secolignans with in vitro anti-inflammatory activities from Urtica fissa rhizomes
Authors: Xiaoru Feng
Mengyue Wang
Jun Cheng
Xiaobo Li
Publication date: 01-07-2017
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 3/2017
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-017-1078-5

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Two new secolignans with in vitro anti-inflammatory activities from Urtica fissa rhizomes

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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