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Published in: Journal of Natural Medicines 1/2017

01-01-2017 | Note

Constituents from Vitex negundo var. heterophylla and their inhibition of nitric oxide production

Authors: Chongyue Qiu, Liang Tong, Ting Yuan, Fei Wang, Feng Zhao, Lixia Chen

Published in: Journal of Natural Medicines | Issue 1/2017

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Abstract

An iridoid glucoside, 10-p-hydroxybenzoyl-6β-hydroxyiridoid 1-O-β-d-(6′-O-p-hydroxybenzoyl)-glucopyranoside (1), and a phenol glucoside, 4-hydroxyphenethanol 3-O-β-d-(6′-O-p-hydroxybenzoyl)-glucopyranoside (2), along with nine known compounds (311) were isolated from the dried leaves of Vitex negundo var. heterophylla. Their structures were elucidated by extensive analysis of NMR spectra. All of the isolated compounds were evaluated for their inhibitory effects on nitric oxide production in RAW 264.7 macrophages. Compounds 2 and 3 exhibited obvious inhibitory effects on NO production with IC50 values of 30.76 and 49.89 μM, respectively. Molecular docking studies of compounds 2 and 3 with nitric oxide synthase (NOS) further confirmed the above results.
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Metadata
Title
Constituents from Vitex negundo var. heterophylla and their inhibition of nitric oxide production
Authors
Chongyue Qiu
Liang Tong
Ting Yuan
Fei Wang
Feng Zhao
Lixia Chen
Publication date
01-01-2017
Publisher
Springer Japan
Published in
Journal of Natural Medicines / Issue 1/2017
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-016-1032-y

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