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01-04-2016 | Original Paper

Three new xanthones from the leaves of Garcinia lancilimba

Authors: Yating Sun, Dahong Li, Cuicui Jia, Chunmei Xue, Jiao Bai, Zhanlin Li, Huiming Hua

Published in: Journal of Natural Medicines | Issue 2/2016

Abstract

Three new prenylated xanthones, garcinexanthones G−I (1–3), together with fifteen known ones (4–18) were identified from the leaves of Garcinia lancilimba. Their structures were determined by extensive spectroscopic analyses. Most of the compounds exhibited inhibitory effects against HL-60 (human leukemia), A549 (human lung cancer), and MCF-7 (human breast cancer) cell lines. Among them, compounds 7, 17, and 13 exhibited the most pronounced growth inhibitory activity against HL-60, A549, and MCF-7 cell lines with GI₅₀ values of 1.68, 4.88, and 6.28 μM, respectively.

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Title: Three new xanthones from the leaves of Garcinia lancilimba
Authors: Yating Sun
Dahong Li
Cuicui Jia
Chunmei Xue
Jiao Bai
Zhanlin Li
Huiming Hua
Publication date: 01-04-2016
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 2/2016
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-015-0950-4

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