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01-07-2007 | Original Paper

The chemical constituents of fresh Gentian Root

Authors: Hidehiro Ando, Yasuaki Hirai, Mikio Fujii, Yumiko Hori, Motonori Fukumura, Yujiro Niiho, Yoshijiro Nakajima, Toshiro Shibata, Kazuo Toriizuka, Yoshiteru Ida

Published in: Journal of Natural Medicines | Issue 3/2007

Abstract

We isolated and characterized 23 compounds, including a new iridoid named gentiolutelin and its dimethyl acetal, and a new lignan named gentioluteol from fresh roots (including small amounts of rhizome) of Gentiana lutea cultivated in Japan (Hokkaido). The structures of gentiolutelin and gentioluteol were determined as (1S,2R,3S,5R)-3-hydroxy-2-methyl-5-(2-oxoethyl)-cyclopentanecarboxylic acid methyl ester and (7R,8S,8′S)-4,4′,8,9-tetrahydroxy-3,3′,5-trimethoxy-7,9′-epoxylignan, respectively, on the basis of chemical and spectroscopic evidence. It was noteworthy that gentiopicroside, known to be a major secoiridoid glycoside in Gentian root, was not detected from the fresh roots of 3-year-old G. lutea.

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Title: The chemical constituents of fresh Gentian Root
Authors: Hidehiro Ando
Yasuaki Hirai
Mikio Fujii
Yumiko Hori
Motonori Fukumura
Yujiro Niiho
Yoshijiro Nakajima
Toshiro Shibata
Kazuo Toriizuka
Yoshiteru Ida
Publication date: 01-07-2007
Publisher: Springer-Verlag
Published in: Journal of Natural Medicines / Issue 3/2007
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-007-0143-x

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The chemical constituents of fresh Gentian Root

Abstract

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Abstract

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