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01-04-2012 | Note

Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum

Authors: De-Wu Zhang, Yan Yang, Fang Yao, Qun-Ying Yu, Sheng-Jun Dai

Published in: Journal of Natural Medicines | Issue 2/2012

Abstract

A new coumestan (solalyratin A, 1) and a novel cyclic eight-membered α,β-unsaturated ketone (solalyratin B, 3), together with three known compounds, puerariafuran (2), coumestrol (4) and 9-hydroxy-2′,2′-dimethylpyrano[5′,6′:2,3]-coumestan (5), were isolated from the whole plant of Solanum lyratum. Their structures were elucidated on the basis of spectroscopic analyses. In vitro, compounds 1–5 showed anti-inflammatory activities, with IC₅₀ values in the range 6.3–9.1 μM.

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Title: Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum
Authors: De-Wu Zhang
Yan Yang
Fang Yao
Qun-Ying Yu
Sheng-Jun Dai
Publication date: 01-04-2012
Publisher: Springer Japan
Published in: Journal of Natural Medicines / Issue 2/2012
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-011-0581-3

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Solalyratins A and B, new anti-inflammatory metabolites from Solanum lyratum

Abstract

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Abstract

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