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Journal of Natural Medicines
Published in: Journal of Natural Medicines 4/2009

01-10-2009 | Original Paper

Ameliorative effects of Vaccaria segetalis extract on osteopenia in ovariectomized rats

Authors: Chun-Ching Shih, Cheng-Hsiu Lin, Wei-Li Lin

Published in: Journal of Natural Medicines | Issue 4/2009

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Abstract

The purpose of this study was to determine the ameliorative effects of a crude extract of Vaccaria segetalis (Neck.) Garcke (Caryophyllaceae) (VSE) on osteopenia in ovariectomized (OVX) rats over 12 weeks. Rats were divided into the sham and OVX groups. The OVX rats were allowed to lose bone for 6 weeks. At 6 weeks post-OVX, the OVX rats were divided into four groups treated with water, 17β-estradiol (30 μg/kg, daily subcutaneous injection), or VSE (0.5 or 1.0 g/kg, daily, orally) for 6 weeks. In OVX rats, the increases of serum total cholesterol were significantly decreased by VSE or 17β-estradiol treatment. There were decreases in bone density and calcium content, including the left femur and the fourth lumbar vertebra, when compared with the sham control rats. Treatment with 17β-estradiol or VSE ameliorated these changes induced by OVX. In addition, ovariectomy increased urinary deoxypyridinoline (DPD) amounts (P < 0.001). The increases were suppressed by 17β-estradiol and 0.5 or 1.0 g/kg VSE (P < 0.01, P < 0.05, P < 0.01, respectively). Our results demonstrated that VSE ameliorates ovariectomy-induced osteopenia by inhibition of bone resorption.
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Metadata
Title
Ameliorative effects of Vaccaria segetalis extract on osteopenia in ovariectomized rats
Authors
Chun-Ching Shih
Cheng-Hsiu Lin
Wei-Li Lin
Publication date
01-10-2009
Publisher
Springer Japan
Published in
Journal of Natural Medicines / Issue 4/2009
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-009-0341-9

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