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Sleep and Breathing
Published in: Sleep and Breathing 3/2022

12-08-2021 | Sleep Apnea | Basic Science • Original Article

Densely granulated adenoma pattern is associated with an increased risk of obstructive sleep apnea in patients with acromegaly

Authors: Xianchao Zhao, Lijun Heng, Yan Qu, Dong Jia, Jiafeng Ren, Shuyu Sun, Jian Qiu, Jinxiang Cheng, Ting Yang, Junying Zhou, Changjun Su

Published in: Sleep and Breathing | Issue 3/2022

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Abstract

Objectives

To explore the prevalence of obstructive sleep apnea (OSA) and the association between the adenoma granulation patterns and OSA in patients with acromegaly.

Methods

An overnight polysomnography (PSG) assessment was carried out on participants with acromegaly. Results classified participants into a non-OSA group, mild to moderate OSA group, and severe OSA group. Morphological and biochemical analyses were performed. Demographic, clinical, biochemical, and polysomnographic data were compared among the three groups. Using logistic regression models, the risk of OSA in acromegalic subjects was estimated.

Results

OSA was reported in 36 of 49 patients (74%) with acromegaly. Contrasted with the non-OSA group, OSA patients had a larger proportion of the densely granulated (DG) pattern. The OSA groups with DG acromegaly had a smaller maximum tumor diameter and Vol/2 than those with the sparsely granulated (SG) pattern. Furthermore, a higher growth hormone (GH) level (45.0 ± 36.9 vs 18.6 ± 15.8, P = 0.047) and GH index (28.4 ± 13.8 vs 6.6 ± 8.2, P = 0.003) were found in DG acromegaly patients with severe OSA. Additionally, there was a trend toward higher standardized insulin-like growth factor 1 (IGF-1) in patients with DG acromegaly than in those with SG acromegaly in the severe OSA group. After adjusting for potential confounding variables, the DG pattern was correlated with the risk of OSA (OR = 14.84, 95%CI 1.36–162.20, P = 0.027) in patients with acromegaly.

Conclusions

The findings indicate that a high prevalence of OSA exists in patients with acromegaly, and the DG pattern may be a risk factor for OSA in acromegaly.
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Metadata
Title
Densely granulated adenoma pattern is associated with an increased risk of obstructive sleep apnea in patients with acromegaly
Authors
Xianchao Zhao
Lijun Heng
Yan Qu
Dong Jia
Jiafeng Ren
Shuyu Sun
Jian Qiu
Jinxiang Cheng
Ting Yang
Junying Zhou
Changjun Su
Publication date
12-08-2021
Publisher
Springer International Publishing
Published in
Sleep and Breathing / Issue 3/2022
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-021-02468-z

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