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01-03-2022 | Affective Disorder | Neurology • Original Article

Evaluation of affective temperament profile and levels of depressive symptoms and anxiety in patients with restless legs syndrome

Authors: Sehnaz Basaran, Halil İbrahim Tas

Published in: Sleep and Breathing | Issue 1/2022

Abstract

Purpose

Restless legs syndrome (RLS) is a sleep-related sensorimotor disorder associated with mood and anxiety disorders. Although affective temperaments are considered subclinical manifestations of mood disorders (MDs), to date, no previous research has explored the relationship between affective temperaments and RLS. We aimed to evaluate affective temperaments, depressive symptoms, and anxiety among newly diagnosed, drug-naive patients with RLS. Additionally, our study identified possible associations between clinical variables and affective temperaments, depressive symptoms, and anxiety profiles in this group.

Methods

The study included 74 patients with RLS and 90 healthy volunteers. All participants performed the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire, Beck Depression Inventory, and Hamilton Anxiety Inventory.

Results

Temperament, depression, and anxiety scores in patients with RLS were significantly higher than those in healthy controls (p ≤ 0.05). Linear regression analysis showed that anxious temperament scores were positively related to longer disease duration (β = 0.658, p = 0.000), whereas disease severity (as measured by the International RLS Study Group Rating Scale) (β = 0.447, p = 0.006) and lower educational status (β = − 0.803, p = 0.008) correlated with the anxiety profile.

Conclusions

Results suggested that higher scores on the affective temperament, depression, and anxiety scales indicate subclinical MDs and psychiatric comorbidities in RLS. Therefore, exploring the predictors of mood and anxiety disorders in patients with RLS may improve treatment strategies and clinical outcomes.

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Title: Evaluation of affective temperament profile and levels of depressive symptoms and anxiety in patients with restless legs syndrome
Authors: Sehnaz Basaran
Halil İbrahim Tas
Publication date: 01-03-2022
Publisher: Springer International Publishing
Keywords: Affective Disorder
Affective Disorder
Restless Legs Syndrome
Anxiety
Published in: Sleep and Breathing / Issue 1/2022
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-021-02375-3

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