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01-03-2021 | Peripheral Arterial Disease | Sleep Breathing Physiology and Disorders • Original Article

Association between sleep-disordered breathing and lower extremity artery disease: a meta-analysis

Authors: Yuhong Chen, Xiaocheng Li, Liming Zhao, Gang Wu

Published in: Sleep and Breathing | Issue 1/2021

Abstract

Objective

Previous studies suggest a relationship between sleep disordered breathing (SDB) and lower extremity artery disease (LEAD) though disagreements remain. This study was performed to assess the association between SDB and LEAD in a metaanalysis.

Methods

PubMed and Embase databases were searched for observational studies. A random-effects model incorporating between-study heterogeneity was used to pool the data.

Results

The search revealed 7 studies including 152,885 participants. Patients with SDB had higher odds of LEAD (risk ratio [RR] = 1.32, 95% confidence interval [CI] = 1.07 to 1.63, p = 0.01, I² = 66%) compared to non-SDB participants. In subgroup analyses, SDB was related to higher odds of LEAD in patients with stroke or diabetes (RR = 3.28, p < 0.001) than in a community-derived population (RR = 1.17, p = 0.08; p for subgroup difference < 0.001). Furthermore, the odds of LEAD was increased in patients with moderate (RR = 1.34, 95% CI = 1.04 to 1.73, p = 0.02) or severe SDB (RR = 1.81, 95% CI = 1.08 to 3.03, p = 0.02), but not in those with mild SDB (RR = 0.94, 95% CI = 0.69 to 1.29, p = 0.71). Differences in study design or methods for LEAD diagnosis did not appear to affect the association between SDB and LEAD.

Conclusions

Patients with SDB have higher odds of LEAD compared to non-SDB participants.

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Title: Association between sleep-disordered breathing and lower extremity artery disease: a meta-analysis
Authors: Yuhong Chen
Xiaocheng Li
Liming Zhao
Gang Wu
Publication date: 01-03-2021
Publisher: Springer International Publishing
Keywords: Peripheral Arterial Disease
Polysomnography
Arterial Occlusive Disease
Arterial Diseases
Peripheral Arterial Disease
Published in: Sleep and Breathing / Issue 1/2021
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-020-02096-z

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