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01-12-2020 | Smelling Disorder | Sleep Breathing Physiology and Disorders • Original Article

The impact of obstructive apnea sleep syndrome on chemical function

Authors: Yifan Liu, Fang Fang, Xiaojun Zhan, Linyin Yao, Yongxiang Wei

Published in: Sleep and Breathing | Issue 4/2020

Abstract

Objective/hypothesis

To investigate the impact of obstructive sleep apnea syndrome (OSAS) on the olfactory and gustatory functions, and the potential mechanisms affecting olfactory and gustatory functions.

Materials and methods

A total of 120 men between the ages of 41 and 70 (mean age (SD) = 56 ± 7.5) were divided into three groups according to polysomnography results: snoring group, mild to moderate OSAS group, and severe OSAS group. Olfactory and gustatory functions were evaluated by the Sniffin’ Sticks test and the triple-drop method, respectively. Otorhinolaryngologic examination, as well as sleep and quality of life questionnaires, were completed by all subjects one day before or after polysomnography.

Results

There was a significant difference in odor thresholds (THR), odor discrimination (OD), odor identification (OI), thresholds-discrimination-identification (TDI) (p < 0.001, p < 0.001, p = 0.003, p < 0.001), and total taste score (p = 0.004, p = 0.021, p = 0.006) in all three groups. Of the subjects in the OSAS group, 43 (54%) exhibited olfactory dysfunction, including 18 subjects (45%) in the mild to moderate group and 25 subjects (63%) in the severe group. Significant negative correlations were found between all olfactory parameters and polysomnography parameters. Furthermore, a negative correlation was present between the total taste scores and the apnea-hypopnea index (AHI).

Conclusion

Men with OSAS exhibited impairment in olfactory and gustatory functions. Significant correlations were found between AHI and olfactory parameters, as well as between AHI and total taste scores.

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Title: The impact of obstructive apnea sleep syndrome on chemical function
Authors: Yifan Liu
Fang Fang
Xiaojun Zhan
Linyin Yao
Yongxiang Wei
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keywords: Smelling Disorder
Sleep Apnea
Smelling Disorder
Polysomnography
Snoring
Published in: Sleep and Breathing / Issue 4/2020
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-020-02022-3

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