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01-12-2020 | Sarcopenia | Sleep Breathing Physiology and Disorders • Review

Sleep duration and sarcopenia risk: a systematic review and dose-response meta-analysis

Authors: Ali Pourmotabbed, Ehsan Ghaedi, Atefeh Babaei, Hamed Mohammadi, Habibolah Khazaie, Cyrus Jalili, Michael E. Symonds, Sajjad Moradi, Maryam Miraghajani

Published in: Sleep and Breathing | Issue 4/2020

Abstract

Purpose

Present systematic literature review and dose-response meta-analysis were carried out to evaluate the association between sleep duration and sarcopenia risk.

Methods

Related studies were found by searching ISI Web of science databases, Scopus, and PubMed, up to May, 2019. Data were available from four studies. A total odds ratio of 17551 participants in these studies was pooled for the current study.

Results

Pooled outcomes from random effects model demonstrated that lowest category of sleep duration (under 6 h) versus reference category (6–8 h) was significantly related with increased risk of sarcopenia (OR: 1.71 95% CI, 1.11, 2.64). Pooled OR also indicated that highest category (more than 8 h) of sleep duration versus reference category (6–8 h) was significantly associated with increased risk of sarcopenia (OR: 1.52 95% CI, 1.23, 1.88). Moreover, subgroup analysis by sex showed that women were affected by both short and long sleep while men were only affected by long sleep duration. The nonlinear dose-response meta-analysis revealed a U-shaped association between sleep duration and the risk of sarcopenia, with a nadir at 8 h per day. The linear dose-response meta-analysis illustrated that the risk of sarcopenia did not change significantly nor for a 0.5-h increment neither for 1-h increment in sleep duration per day.

Conclusion

The outcomes from this meta-analysis indicate that the public should be made aware of the negative consequences of long and short sleep for sarcopenia especially among women. Further studies should now be undertaken to establish possible links between risk of sarcopenia and sleep duration.

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Title: Sleep duration and sarcopenia risk: a systematic review and dose-response meta-analysis
Authors: Ali Pourmotabbed
Ehsan Ghaedi
Atefeh Babaei
Hamed Mohammadi
Habibolah Khazaie
Cyrus Jalili
Michael E. Symonds
Sajjad Moradi
Maryam Miraghajani
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keyword: Sarcopenia
Published in: Sleep and Breathing / Issue 4/2020
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-019-01965-6

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