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01-09-2020 | Sleep Apnea | Sleep Breathing Physiology and Disorders • Original Article

Insufficiency of positive airway pressure treatment on increased mean platelet volume: a prospective controlled study in patients with obstructive sleep apnea syndrome

Authors: Bülent Ulusoy, Tolga Oğuzhan, Mesut Akyol, Kazım Bozdemir, Bülent Çiftçi, Mehmet Hakan Korkmaz

Published in: Sleep and Breathing | Issue 3/2020

Abstract

Background

To analyze the association between obstructive sleep apnea syndrome (OSAS) and some hematological variables such as mean platelet volume (MPV), platelet distribution width (PDW), and the impact of positive airway pressure (PAP) treatment on these parameters.

Methods

The participants of the present prospective study consist of 36 OSAS patients diagnosed with polysomnography and recommended PAP treatment and 30 healthy members as the control group. Complete blood analyses were conducted to the patient group twice; before the initiation of the PAP treatment and 1 month after regular PAP use. The control group was administered a complete blood analyses only once. Patient and control group were compared in terms of various parameters such as MPV, PDW, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), white blood cell (WBC) values, and platelet counts.

Results

MPV value of the patient group was before and after PAP treatment significantly higher than the control group (respectively; Z = 2.246; p = 0.025, and Z = 2.033; p = 0.042). However, there were no statistically significant differences in the values before and after PAP treatment in the patient group (Z = 0.727; p = 0.467). In terms of platelet numbers and PDW values, no significant differences were determined (p > 0.05).

Conclusion

MPV value was significantly elevated in OSAS patients. However, the 1 month of PAP treatment was insufficient in decreasing elevated MPV values.

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Title: Insufficiency of positive airway pressure treatment on increased mean platelet volume: a prospective controlled study in patients with obstructive sleep apnea syndrome
Authors: Bülent Ulusoy
Tolga Oğuzhan
Mesut Akyol
Kazım Bozdemir
Bülent Çiftçi
Mehmet Hakan Korkmaz
Publication date: 01-09-2020
Publisher: Springer International Publishing
Keywords: Sleep Apnea
Polysomnography
Thrombosis
Published in: Sleep and Breathing / Issue 3/2020
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-019-01918-z

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Results

Conclusion

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