Skip to main content
Top
Published in: Sleep and Breathing 2/2020

01-06-2020 | Sleep Apnea | Sleep Breathing Physiology and Disorders • Original Article

Accessibility and adherence to positive airway pressure treatment in patients with obstructive sleep apnea: a multicenter study in Latin America

Authors: Juan Facundo Nogueira, Dalva Poyares, Guido Simonelli, Sebastián Leiva, José Luis Carrillo-Alduenda, María Angélica Bazurto, Guadalupe Terán, Matilde Valencia-Flores, Leonardo Serra, Jorge Rey de Castro, Victoria Santiago-Ayala, Daniel Pérez-Chada, María Eugenia Franchi, Ligia Lucchesi, Sergio Tufik, Lia Bittencourt

Published in: Sleep and Breathing | Issue 2/2020

Login to get access

Abstract

Purpose

Information on access and adherence to positive airway pressure (PAP) treatment is lacking at the regional level in Latin America. This study characterized access and adherence to PAP in patients with moderate-severe obstructive sleep apnea (OSA) in Latin America.

Methods

Cross-sectional study, conducted at 9 sleep centers across Argentina, Brazil, Chile, Colombia, Mexico, and Peru. Adults diagnosed with moderate-severe OSA (apnea-hypopnea index [AHI] ≥ 15/h) in the previous 12–18 months were eligible. Anthropometrics, health coverage, and OSA severity data were collected. Data on access to therapy, barriers to access, adherence, and factors related to non-compliance were obtained via standardized telephone survey.

Results

Eight hundred eighty patients (70% male, 54 ± 13 years, AHI 49 ± 28/h, body mass index 32 ± 7 kg/m2) were included. Four hundred ninety patients (56%) initiated PAP, 70 (14%) discontinued therapy during the first year (mainly due to intolerance), and 420 (48%) were still using PAP when surveyed. Health insurance was private in 36.9% of patients, via the social security system in 31.1%, and via the state in 13.3%, and 18.7% did not have any coverage; 49.5% of patients had to pay all equipment costs. Reasons for not starting PAP were unclear or absent indication (42%), coverage problems (36%), and lack of awareness of OSA burden (14%). Patients with better adherence were older (55.3 ± 13 vs 52 ± 13; p = 0.002) and had more severe OSA (AHI 51.8 ± 27 vs 45.6 ± 27; p = 0.001).

Conclusions

Less than half moderate-severe OSA patients started and continue to use PAP. Unclear or absent medical indication and financial limitations were the most relevant factors limiting access to therapy.
Appendix
Available only for authorised users
Literature
1.
go back to reference Nogueira F, Nigro C, Cambursano H, Borsini E, Silio J, Avila J (2013) Practical guidelines for the diagnosis and treatment of obstructive sleep apnea syndrome. Medicina (B Aires) 73:349–362 Nogueira F, Nigro C, Cambursano H, Borsini E, Silio J, Avila J (2013) Practical guidelines for the diagnosis and treatment of obstructive sleep apnea syndrome. Medicina (B Aires) 73:349–362
2.
go back to reference Grupo Español de Sueño (2005) Consenso Nacional sobre el síndrome de apneas-hipopneas del sueño. Arch Bronconeumol 41(Supl 4):3–4 Grupo Español de Sueño (2005) Consenso Nacional sobre el síndrome de apneas-hipopneas del sueño. Arch Bronconeumol 41(Supl 4):3–4
3.
go back to reference Eckert D, White D, Jordan A, Malhotra A, Wellman A (2013) Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets. Am J Respir Crit Care 188(8):996–1004CrossRef Eckert D, White D, Jordan A, Malhotra A, Wellman A (2013) Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets. Am J Respir Crit Care 188(8):996–1004CrossRef
4.
go back to reference Tufik S, Santos-Silva R, Taddei JA, Bittencourt LRA (2010) Obstructive sleep apnea syndrome in the Sao Paulo epidemiologic sleep study. Sleep Med 11(5):441–446CrossRef Tufik S, Santos-Silva R, Taddei JA, Bittencourt LRA (2010) Obstructive sleep apnea syndrome in the Sao Paulo epidemiologic sleep study. Sleep Med 11(5):441–446CrossRef
5.
go back to reference Heinzer R, Vat S, Marques-Vidal P, Marti-Soler H, Andries D, Tobback N, Mooser V, Preisig M, Malhotra A, Waeber G, Vollenweider P, Tafti M, Haba-Rubio J (2015) Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study. Lancet Respir Med 3:310–318CrossRef Heinzer R, Vat S, Marques-Vidal P, Marti-Soler H, Andries D, Tobback N, Mooser V, Preisig M, Malhotra A, Waeber G, Vollenweider P, Tafti M, Haba-Rubio J (2015) Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study. Lancet Respir Med 3:310–318CrossRef
6.
go back to reference Arnardottir ES, Bjornsdottir E, Olafsdottir KA, Benediktsdottir B, Gislason T (2016) Obstructive sleep apnoea in the general population: highly prevalent but minimal symptoms. Eur Respir J 47(1):194–202CrossRef Arnardottir ES, Bjornsdottir E, Olafsdottir KA, Benediktsdottir B, Gislason T (2016) Obstructive sleep apnoea in the general population: highly prevalent but minimal symptoms. Eur Respir J 47(1):194–202CrossRef
7.
go back to reference Marin JM, Carrizo SJ, Vicente E, Agusti AG (2005) Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 365:1046–1053CrossRef Marin JM, Carrizo SJ, Vicente E, Agusti AG (2005) Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 365:1046–1053CrossRef
8.
go back to reference Marti S, Sampol G, Muñoz X, Torres F, Roca A, Lloberes P, Sagalés T, Quesadaz P, Morell F (2002) Mortality in severe sleep apnoea/hypopnoea syndrome patients: impact of treatment. Eur Respir J 20:1511–1518CrossRef Marti S, Sampol G, Muñoz X, Torres F, Roca A, Lloberes P, Sagalés T, Quesadaz P, Morell F (2002) Mortality in severe sleep apnoea/hypopnoea syndrome patients: impact of treatment. Eur Respir J 20:1511–1518CrossRef
9.
go back to reference Pelletier-Fleury N, Meslier N, Gagnadoux F, Person C, Rakotonanahary D, Ouksel K, Fleury B, Racineux L (2004) Economic arguments for the immediate management of moderate to severe obstructive sleep apnoea syndrome. Eur Respir J 23:53–60CrossRef Pelletier-Fleury N, Meslier N, Gagnadoux F, Person C, Rakotonanahary D, Ouksel K, Fleury B, Racineux L (2004) Economic arguments for the immediate management of moderate to severe obstructive sleep apnoea syndrome. Eur Respir J 23:53–60CrossRef
10.
go back to reference González Mangado N, Troncoso Acevedo M, Gómez García T (2014) Home ventilation therapy in obstructive sleep apnea-hypopnea syndrome. Arch Bronconeumol 50:528–534CrossRef González Mangado N, Troncoso Acevedo M, Gómez García T (2014) Home ventilation therapy in obstructive sleep apnea-hypopnea syndrome. Arch Bronconeumol 50:528–534CrossRef
11.
go back to reference Weaver T, Grunstein R (2008) Adherence to continuous positive airway pressure therapy the challenge to effective treatment. Proc Am Thorac Soc 5:173–178CrossRef Weaver T, Grunstein R (2008) Adherence to continuous positive airway pressure therapy the challenge to effective treatment. Proc Am Thorac Soc 5:173–178CrossRef
12.
go back to reference Sawyer A, Gooneratne N, Marcus C, Ofer D, Richards K, Weaver T (2011) A systematic review of CPAP adherence across age groups: clinical and empiric insights for developing CPAP adherence interventions. Sleep Med Rev 15:343–356CrossRef Sawyer A, Gooneratne N, Marcus C, Ofer D, Richards K, Weaver T (2011) A systematic review of CPAP adherence across age groups: clinical and empiric insights for developing CPAP adherence interventions. Sleep Med Rev 15:343–356CrossRef
13.
go back to reference Nogueira JF, Borsini E, Nigro C (2016) Estrategias para mejorar la adaptación al tratamiento con CPAP en pacientes con SAHOS. Rev Am Med Resp 4:365–377 Nogueira JF, Borsini E, Nigro C (2016) Estrategias para mejorar la adaptación al tratamiento con CPAP en pacientes con SAHOS. Rev Am Med Resp 4:365–377
14.
go back to reference Facundo N, De Luca M, Simonelli G, Vera D, Vera S, Rey R (2017) ¿Qué pasa con los pacientes luego de que se les diagnostica Apneas del Sueño? Rev Am Med Resp 2:41–47 Facundo N, De Luca M, Simonelli G, Vera D, Vera S, Rey R (2017) ¿Qué pasa con los pacientes luego de que se les diagnostica Apneas del Sueño? Rev Am Med Resp 2:41–47
15.
go back to reference Torre Bouscoulet L, López Escárcega E, Castorena Maldonado A, Vázquez García JC, Meza Vargas MS, Pérez-Padilla R (2007) Continuous positive airway pressure used by adults with obstructive sleep apneas after prescription in a public referral hospital in Mexico City. Arch Bronconeumol 43(1):16–21CrossRef Torre Bouscoulet L, López Escárcega E, Castorena Maldonado A, Vázquez García JC, Meza Vargas MS, Pérez-Padilla R (2007) Continuous positive airway pressure used by adults with obstructive sleep apneas after prescription in a public referral hospital in Mexico City. Arch Bronconeumol 43(1):16–21CrossRef
16.
go back to reference Santín K, Jorquera J, Jordán J, Bajut F, Masalán P, Mesa T, Kuester G, Godoy J (2007) Uso de CPAP nasal en el largo plazo en síndrome de apnea-hipopnea del sueño. Rev Méd Chile 135:855–861CrossRef Santín K, Jorquera J, Jordán J, Bajut F, Masalán P, Mesa T, Kuester G, Godoy J (2007) Uso de CPAP nasal en el largo plazo en síndrome de apnea-hipopnea del sueño. Rev Méd Chile 135:855–861CrossRef
18.
go back to reference Morgenthaler TI, Aurora RN, Brown T, Zak R, Alessi C, Boehlecke B, Chesson AL, Friedman L, Kapur V, Maganti R, Owens J, Pancer J, Swick TJ (2008) Standards of Practice Committee of the AASM. Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: an update for 2007. Sleep 31(1):141–147CrossRef Morgenthaler TI, Aurora RN, Brown T, Zak R, Alessi C, Boehlecke B, Chesson AL, Friedman L, Kapur V, Maganti R, Owens J, Pancer J, Swick TJ (2008) Standards of Practice Committee of the AASM. Practice parameters for the use of autotitrating continuous positive airway pressure devices for titrating pressures and treating adult patients with obstructive sleep apnea syndrome: an update for 2007. Sleep 31(1):141–147CrossRef
19.
go back to reference Epstein L, Kristo D, Strollo P, Friedman N, Malhotra A, Patil SP, Ramar K, Rogers R, Schwab R, Weaver E, Weinstein M (2009) Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med 5:263–276CrossRef Epstein L, Kristo D, Strollo P, Friedman N, Malhotra A, Patil SP, Ramar K, Rogers R, Schwab R, Weaver E, Weinstein M (2009) Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med 5:263–276CrossRef
22.
go back to reference Nogueira JF, Simonelli G, Giovini V, Angellotti F, Borsini E, Ernst G, Nigro C (2018) Access to CPAP treatment in patients with moderate to severe sleep apnea in a Latin American City. Sleep Sci 11(3):174–182CrossRef Nogueira JF, Simonelli G, Giovini V, Angellotti F, Borsini E, Ernst G, Nigro C (2018) Access to CPAP treatment in patients with moderate to severe sleep apnea in a Latin American City. Sleep Sci 11(3):174–182CrossRef
23.
go back to reference McArdle N, Devereux G, Heidarnejad H, Engleman HM, Mackay TW, Douglas NJ (1999) Long-term use of CPAP therapy for sleep apnea/hypopnea syndrome. Am J Respir Crit Care Med 159:1108–1114CrossRef McArdle N, Devereux G, Heidarnejad H, Engleman HM, Mackay TW, Douglas NJ (1999) Long-term use of CPAP therapy for sleep apnea/hypopnea syndrome. Am J Respir Crit Care Med 159:1108–1114CrossRef
24.
go back to reference Meslier N, Lebrun T, Grillier-Lanoir V, Rolland N, Henderick C, Sailly J, Racineux J (1998) A French survey of 3,225 patients treated with CPAP for obstructive sleep apnoea: benefits, tolerance, compliance and quality of life. Eur Respir J 12:185–192CrossRef Meslier N, Lebrun T, Grillier-Lanoir V, Rolland N, Henderick C, Sailly J, Racineux J (1998) A French survey of 3,225 patients treated with CPAP for obstructive sleep apnoea: benefits, tolerance, compliance and quality of life. Eur Respir J 12:185–192CrossRef
25.
go back to reference Pépin JL, Krieger J, Rodenstein D, Cornette A, Sforza E, Delguste P, Deschaux C, Grillier V, Lévy P (1999) Effective compliance during the first 3 months of continuous positive airway pressure: a European prospective study of 121 patients. Am J Respir Crit Care Med 160:1124–1129CrossRef Pépin JL, Krieger J, Rodenstein D, Cornette A, Sforza E, Delguste P, Deschaux C, Grillier V, Lévy P (1999) Effective compliance during the first 3 months of continuous positive airway pressure: a European prospective study of 121 patients. Am J Respir Crit Care Med 160:1124–1129CrossRef
26.
go back to reference Sin D, Mayers I, Godfrey C, Man W, Pawluk L (2002) Long-term compliance rates to continuous positive airway pressure in obstructive sleep apnea. A population-Based Study. Chest 121:430–435CrossRef Sin D, Mayers I, Godfrey C, Man W, Pawluk L (2002) Long-term compliance rates to continuous positive airway pressure in obstructive sleep apnea. A population-Based Study. Chest 121:430–435CrossRef
27.
go back to reference Wolkove N, Baltzan M, Kamel H, Dabrusin R, Palayew M (2008) Long-term compliance with continuous positive airway pressure in patients with obstructive sleep apnea. Can Respir J 15(7):365–369CrossRef Wolkove N, Baltzan M, Kamel H, Dabrusin R, Palayew M (2008) Long-term compliance with continuous positive airway pressure in patients with obstructive sleep apnea. Can Respir J 15(7):365–369CrossRef
28.
go back to reference Wang Y, Gao W, Sun M, Chen B (2012) Adherence to CPAP in patients with obstructive sleep apnea in a Chinese population. Respir Care 57(2):238–243 Wang Y, Gao W, Sun M, Chen B (2012) Adherence to CPAP in patients with obstructive sleep apnea in a Chinese population. Respir Care 57(2):238–243
29.
go back to reference Terán Santos J, Fernández García C, Cordero Guevara J (2000) Continuous positive airway pressure for obstructive sleep apnea syndrome: the current state of diagnostic resources and therapy in Spain. Arch Bronconeumol 36:494–499CrossRef Terán Santos J, Fernández García C, Cordero Guevara J (2000) Continuous positive airway pressure for obstructive sleep apnea syndrome: the current state of diagnostic resources and therapy in Spain. Arch Bronconeumol 36:494–499CrossRef
30.
go back to reference Simon-Tuval T, Reuveni H, Greenberg-Dotan S, Oksenberg A, Tal A, Tarasiuk A (2009) Low socioeconomic status is a risk factor for CPAP acceptance among adult OSAS patients requiring treatment. Sleep 32(4):545–552CrossRef Simon-Tuval T, Reuveni H, Greenberg-Dotan S, Oksenberg A, Tal A, Tarasiuk A (2009) Low socioeconomic status is a risk factor for CPAP acceptance among adult OSAS patients requiring treatment. Sleep 32(4):545–552CrossRef
31.
go back to reference Meurice JC, Ingrand P, Portier F, Arnulf I, Rakotonanahari D, Fournier E, Philip-Joet F, Veale D (2007) A multicentre trial of education strategies at CPAP induction in the treatment of severe sleep apnoea-hypopnoea syndrome. Sleep Med 8:37–42CrossRef Meurice JC, Ingrand P, Portier F, Arnulf I, Rakotonanahari D, Fournier E, Philip-Joet F, Veale D (2007) A multicentre trial of education strategies at CPAP induction in the treatment of severe sleep apnoea-hypopnoea syndrome. Sleep Med 8:37–42CrossRef
33.
go back to reference Dourado Rueda A, Santos-Silva R, Togeiro S, Tufik S, Azeredo Bittencourt L (2009) Improving CPAP compliance by a basic educational program with nurse support for obstructive sleep apnea syndrome patients. Sleep Sci 2(1):8–13 Dourado Rueda A, Santos-Silva R, Togeiro S, Tufik S, Azeredo Bittencourt L (2009) Improving CPAP compliance by a basic educational program with nurse support for obstructive sleep apnea syndrome patients. Sleep Sci 2(1):8–13
34.
go back to reference Deng T, Wang Y, Sun M, Chen B (2013) Stage-matched intervention for adherence to CPAP in patients with obstructive sleep apnea: a randomized controlled trial. Sleep Breath 17:791–801CrossRef Deng T, Wang Y, Sun M, Chen B (2013) Stage-matched intervention for adherence to CPAP in patients with obstructive sleep apnea: a randomized controlled trial. Sleep Breath 17:791–801CrossRef
35.
go back to reference Amfilochiou A, Tsara V, Kolilekas L, Gizopoulou E, Maniou C, Bouros D, Polychronopoulos V (2009) Determinants of continuous positive airway pressure compliance in a group of Greek patients with obstructive sleep apnea. Eur J Intern Med 6:645–650CrossRef Amfilochiou A, Tsara V, Kolilekas L, Gizopoulou E, Maniou C, Bouros D, Polychronopoulos V (2009) Determinants of continuous positive airway pressure compliance in a group of Greek patients with obstructive sleep apnea. Eur J Intern Med 6:645–650CrossRef
36.
go back to reference Pelletier-Fleury N, Rakotonanahary D, Fleury B (2001) The age and other factors in the evaluation of compliance with nasal continuous positive airway pressure for obstructive sleep apnea syndrome. A Cox’s proportional hazard analysis. Sleep Med 2(3):225–232CrossRef Pelletier-Fleury N, Rakotonanahary D, Fleury B (2001) The age and other factors in the evaluation of compliance with nasal continuous positive airway pressure for obstructive sleep apnea syndrome. A Cox’s proportional hazard analysis. Sleep Med 2(3):225–232CrossRef
37.
go back to reference Kribbs NB, Pack AI, Kline LR, Smith PL, Schwartz AR, Schubert NM, Redline S, Henry JN, Getsy JE, Dinges DF (1993) Objective measurement of patterns of nasal CPAP use by patients with obstructive sleep apnea. Am Rev Respir Dis 147:887–895CrossRef Kribbs NB, Pack AI, Kline LR, Smith PL, Schwartz AR, Schubert NM, Redline S, Henry JN, Getsy JE, Dinges DF (1993) Objective measurement of patterns of nasal CPAP use by patients with obstructive sleep apnea. Am Rev Respir Dis 147:887–895CrossRef
38.
go back to reference Arcos J, López V, Musetti A, Mamchur M, Gutiérrez M, Otaño N et al (2012) Trastornos respiratorios del sueño: Guías clínicas para el diagnóstico y tratamiento. Rev Méd Urug 28:274–308 Arcos J, López V, Musetti A, Mamchur M, Gutiérrez M, Otaño N et al (2012) Trastornos respiratorios del sueño: Guías clínicas para el diagnóstico y tratamiento. Rev Méd Urug 28:274–308
Metadata
Title
Accessibility and adherence to positive airway pressure treatment in patients with obstructive sleep apnea: a multicenter study in Latin America
Authors
Juan Facundo Nogueira
Dalva Poyares
Guido Simonelli
Sebastián Leiva
José Luis Carrillo-Alduenda
María Angélica Bazurto
Guadalupe Terán
Matilde Valencia-Flores
Leonardo Serra
Jorge Rey de Castro
Victoria Santiago-Ayala
Daniel Pérez-Chada
María Eugenia Franchi
Ligia Lucchesi
Sergio Tufik
Lia Bittencourt
Publication date
01-06-2020
Publisher
Springer International Publishing
Keyword
Sleep Apnea
Published in
Sleep and Breathing / Issue 2/2020
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-019-01881-9

Other articles of this Issue 2/2020

Sleep and Breathing 2/2020 Go to the issue

Sleep Breathing Physiology and Disorders • Review

Excessive daytime sleepiness and fatigue in neurological disorders

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.