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01-06-2019 | Sleep Breathing Physiology and Disorders • Original Article

Do you have restless leg syndrome? I understood from your eyes

Authors: Hatice Kose Ozlece, Volkan Solmaz, Sadık Altan Özal, Yahya Çelik

Published in: Sleep and Breathing | Issue 2/2019

Abstract

Purpose

According to many studies in the literature, there is a strong association between restless leg syndrome and dopaminergic dysfunction. Dopamine is also the major catecholamine in the retina and is also a possible transmitter of the amacrine and interplexiform cells. The aim of this study is to investigate the possible association between RLS and retinal thickness.

Methods

In this study, we included 33 patients who were diagnosed with idiopathic RLS according to the “International RLS Study Group” criteria and 31 healthy subjects. All the patients and controls underwent routine ophthalmologic examination and had spectral-domain optical coherence tomography (OCT) performed. We compared the retinal thickness of the patients and control subjects.

Results

In the RLS group, foveal thickness was thinner then controls. Also, only inferior, superior, and temporal quadrant retina nerve fiber layer (RNFL) thickness were significantly thinner in the RLS group. The parafoveal ganglion cell complex (GCC) in the superior temporal, inferior temporal, inferior nasal quadrant, and perifoveal superior nasal thickness was also significantly thinner in the patient group. Pearson correlation analyses showed that there were statistically significant negative correlations between disease duration and macular GCC and RNFL thickness. Negative correlations were also detected between parafoveal superior, temporal, inferior and nasal macular thickness, parafoveal superior nasal, inferior temporal GCC thickness, and perifoveal superior nasal GCC thickness and disease duration.

Conclusion

According to our results; most retinal layers are thinner in RLS patients, so it can be considered that OCT has a predictive value for progression of RLS.

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Title: Do you have restless leg syndrome? I understood from your eyes
Authors: Hatice Kose Ozlece
Volkan Solmaz
Sadık Altan Özal
Yahya Çelik
Publication date: 01-06-2019
Publisher: Springer International Publishing
Published in: Sleep and Breathing / Issue 2/2019
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-018-1740-5

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