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Sleep and Breathing

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01-03-2019 | Sleep Breathing Physiology and Disorders • Original Article

Arterial stiffness alteration and obstructive sleep apnea in an elderly cohort free of cardiovascular event history: the PROOF cohort study

Authors: Emilia Sforza, Sandrine Millasseau, David Hupin, Jean-Claude Barthélémy, Frédéric Roche

Published in: Sleep and Breathing | Issue 1/2019

Abstract

Introduction

Several studies suggest in middle-aged subjects a relationship between arterial stiffness, a cardiovascular risk marker, and moderate to severe obstructive sleep apnea (OSA). No extensive data are present in older subjects. This study explores this association in a sample of healthy older subjects suffering OSA.

Methods

A total of 101 volunteers aged 75.3 ± 0.7 years were examined at the hospital sleep center. Each subject was assessed for medical history, body mass index and 24-h blood pressure measures, biological blood samples, and home polygraphy in 2002–2003 (P2) as well as in 2009–2010 (P4). Arterial stiffness was also assessed using carotid-femoral and carotid-radial pulse wave velocity (cfPWV and crPWV) during P4 examination.

Results

The total group consisted of 59 women and 42 men with a mean apnea-hypopnea index (AHI) of 17.8 ± 12.1 and a mean oxygen desaturation index (ODI) of 9.8 ± 8.9. No-OSA (AHI < 15) represented 50% of the sample, and severe cases (AHI > 30) 17%. No significant differences had been founded between men and women for blood pressure, cfPWV, and crPWV. Considering the severity of the AHI, no significant differences between groups were present for PWV and blood pressure values. No difference for PWV was present for subjects with and without hypertension. No correlation was found between PWV value and AHI and ODI values at P2 or between P2 and P4 visits. cfPWV was higher in patients demonstrating incident hypertension during the follow-up.

Conclusions

In this sample of older subjects, PWV is not affected by AHI and ODI but was associated with incident hypertension. These results may suggest potential protective and adaptive mechanisms in older sleep apnea patients.

Clinical trial registrations

NCT 00759304 and NCT 00766584.

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Title: Arterial stiffness alteration and obstructive sleep apnea in an elderly cohort free of cardiovascular event history: the PROOF cohort study
Authors: Emilia Sforza
Sandrine Millasseau
David Hupin
Jean-Claude Barthélémy
Frédéric Roche
Publication date: 01-03-2019
Publisher: Springer International Publishing
Published in: Sleep and Breathing / Issue 1/2019
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI: https://doi.org/10.1007/s11325-018-1683-x

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Arterial stiffness alteration and obstructive sleep apnea in an elderly cohort free of cardiovascular event history: the PROOF cohort study

Abstract

Introduction

Methods

Results

Conclusions

Clinical trial registrations

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Abstract

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Conclusions

Clinical trial registrations

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