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Published in: Sleep and Breathing 4/2017

01-12-2017 | Epidemiology • Original Article

Validation of NoSAS score for screening of sleep-disordered breathing in a multiethnic Asian population

Authors: Adeline Tan, Yueheng Hong, Linda W.L. Tan, Rob M. van Dam, Yan Yi Cheung, Chi-Hang Lee

Published in: Sleep and Breathing | Issue 4/2017

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Abstract

Purpose

The NoSAS score was developed to identify subjects at high risk of sleep-disordered breathing (SDB). We aimed to validate the NoSAS score in a multiethnic Asian cohort and compare its performance to the STOP-Bang and Berlin questionnaires.

Methods

A sample of 242 subjects selected from a population-based cohort in Singapore completed home-based sleep testing with an Embletta device (type 3 monitor). All subjects were given the STOP-Bang and Berlin questionnaires for self-administration prior to the sleep study. The NoSAS score was subsequently calculated based on available demographic data and Berlin questionnaire responses.

Results

The prevalence of severe SDB, defined as an apnea-hypopnea index cutoff of ≥30 events/h, was 10.7%. The number of subjects who were classified as high risk by the NoSAS score and STOP-Bang and Berlin questionnaires were 76 (31.4%), 89 (36.8%), and 79 (32.6%), respectively. The sensitivity, specificity, and negative and positive predictive values of the NoSAS score to predict severe SDB were 69.2, 73.1, 95.2, and 23.7%, respectively. The STOP-Bang and Berlin questionnaires performed similarly to the NoSAS score, with area under the curve (AUC) values of all three questionnaires clustered around 0.682–0.748. Compared to the STOP-Bang (94.8%) and Berlin questionnaires (96.3%), the NoSAS score (95.2%) had equally high negative predictive value in ruling out severe SDB.

Conclusions

The NoSAS score performed similarly to the STOP-Bang and Berlin questionnaires in a multiethnic Asian cohort. All three questionnaires had high negative predictive values in ruling out severe SDB and may have utility as screening tools.
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Metadata
Title
Validation of NoSAS score for screening of sleep-disordered breathing in a multiethnic Asian population
Authors
Adeline Tan
Yueheng Hong
Linda W.L. Tan
Rob M. van Dam
Yan Yi Cheung
Chi-Hang Lee
Publication date
01-12-2017
Publisher
Springer International Publishing
Published in
Sleep and Breathing / Issue 4/2017
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-016-1455-4

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