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Sleep and Breathing
Published in: Sleep and Breathing 4/2015

01-12-2015 | Original Article

Microalbuminuria in obstructive sleep apnea syndrome

Authors: Emel Bulcun, Mehmet Ekici, Aydanur Ekici, Dilay Ahat Cimen, Ucler Kisa

Published in: Sleep and Breathing | Issue 4/2015

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Abstract

Objectives

Microalbuminuria is an important risk factor for cardiovascular diseases. Microalbuminuria may be seen due to intermittent hypoxemia in patients with obstructive sleep apnea syndrome (OSAS). In this study, we investigated the prevalence and relationship of microalbuminuria with clinical and physiological parameters in patients with OSAS.

Method

Ninety-eight patients with OSAS and 26 nonapneic snoring subjects upon polysomnography were included in this study. The urinary albumin-to-creatinine ratio (UACR) was calculated according to a previously described formula. The severity index of chronic diseases was evaluated by using the modified cumulative illness rating scale (MCIRS). Insulin resistance (IR) method was analyzed by homeostasis assessment model (HOMA-IR). Subjective sleepiness was assessed using the Epworth sleepiness scale (ESS).

Results

Body mass index (BMI), MCIRS, and UACR were higher in patients with OSAS than nonapneic snoring subjects. In linear regression model, there was a negative relationship between UACR and minimal O2, and there was a significantly positive relationship between UACR and desaturation index.

Conclusion

Microalbuminuria may be seen in patients with OSAS, depending on the severity of disease and hypoxemia. Microalbuminuria in patients with OSAS should be examined in regular periods for risk of cardiovascular morbidity or mortality.
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Metadata
Title
Microalbuminuria in obstructive sleep apnea syndrome
Authors
Emel Bulcun
Mehmet Ekici
Aydanur Ekici
Dilay Ahat Cimen
Ucler Kisa
Publication date
01-12-2015
Publisher
Springer Berlin Heidelberg
Published in
Sleep and Breathing / Issue 4/2015
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-015-1136-8

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