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Sleep and Breathing
Published in: Sleep and Breathing 3/2013

01-09-2013 | Review

Oxidative stress, cancer, and sleep deprivation: is there a logical link in this association?

Authors: Juliana Noguti, Monica Levy Andersen, Chiara Cirelli, Daniel Araki Ribeiro

Published in: Sleep and Breathing | Issue 3/2013

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Abstract

Introduction

Sleep disorders are associated with various human pathologies and interfere with biological processes essential for health and quality of life. On the other hand, cancer is one of the most common diseases worldwide with an average of 1,500 deaths per day in the USA. Is there a factor common to both sleep disorders and cancer that serves to link these conditions?

Discussion

It is a normal process for cellular metabolism to produce reactive oxidant series (ROS). However, when the production of ROS overcomes the antioxidant capacity of the cell to eliminate these products, the resulting state is called oxidative stress. Oxidative DNA damage may participate in ROS-induced carcinogenesis. Moreover, ROS are also produced in the sleep deprivation process. The aim of this article is to review pathways and mechanisms that may point to oxidative stress as a link between sleep deprivation and cancer.
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Metadata
Title
Oxidative stress, cancer, and sleep deprivation: is there a logical link in this association?
Authors
Juliana Noguti
Monica Levy Andersen
Chiara Cirelli
Daniel Araki Ribeiro
Publication date
01-09-2013
Publisher
Springer Berlin Heidelberg
Published in
Sleep and Breathing / Issue 3/2013
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-012-0797-9

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