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Molecular Imaging and Biology
Published in: Molecular Imaging and Biology 5/2008

Open Access 01-09-2008 | Research Arti cle

Bone Metabolism after Total Hip Revision Surgery with Impacted Grafting: Evaluation using H2 15O and [18F]fluoride PET; A Pilot Study

Authors: Olivier P. P. Temmerman, Pieter G. H. M. Raijmakers, Ide C. Heyligers, Emile F. I. Comans, Mark Lubberink, Gerrit J. J. Teule, Adriaan A. Lammertsma

Published in: Molecular Imaging and Biology | Issue 5/2008

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Abstract

Purpose

To evaluate bone blood flow and bone formation in patients after total hip revision surgery with impacted bone grafting using H2 15O and [18F]fluoride positron emission tomography (PET).

Procedures

To asses bone blood flow and bone metabolism in bone allograft after impaction grafting, four patients treated with total hip revision surgery were enrolled prospectively in this study. Six patients scheduled for primary hip arthroplasties were included as a control group. The study protocol consisted of three H2 15O and [18F]fluoride PET scans in each patient.

Results

Bone blood flow increased significantly compared to the preoperative state in patients treated for primary hip arthroplasty. In patients undergoing revision surgery, bone blood flow was twofold to threefold higher compared to the preoperative state, but did not reach significance. Bone metabolism in patients undergoing revision was threefold higher 2 weeks postoperatively compared to the primary hip group. We found a significant correlation between Ki and bone blood flow.

Conclusions

Allogeneic bone grafts induce a higher rate of local periprosthetic bone formation compared to periprosthetic bone formation after a primary total hip placement. In vivo coupling between bone blood flow and bone metabolism suggests that bone metabolism in allogeneic bone grafts may partly rely on bone blood flow adaptations.
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Metadata
Title
Bone Metabolism after Total Hip Revision Surgery with Impacted Grafting: Evaluation using H2 15O and [18F]fluoride PET; A Pilot Study
Authors
Olivier P. P. Temmerman
Pieter G. H. M. Raijmakers
Ide C. Heyligers
Emile F. I. Comans
Mark Lubberink
Gerrit J. J. Teule
Adriaan A. Lammertsma
Publication date
01-09-2008
Publisher
Springer-Verlag
Published in
Molecular Imaging and Biology / Issue 5/2008
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-008-0153-4

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