Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Oral Radiology
Published in: Oral Radiology 3/2017

01-09-2017 | Review Article

Basic and important points regarding the diagnosis of oral cancers using fluorine-18-labeled fluoro-2-deoxy-d-glucose positron emission tomography–computed tomography: a review

Authors: Shinji Kito, Hirofumi Koga, Masafumi Oda, Tatsurou Tanaka, Masaaki Kodama, Manabu Habu, Ikuya Miyamoto, Shinya Kokuryo, Noriaki Yamamoto, Nao Wakasugi-Sato, Shinobu Matsumoto-Takeda, Daigo Yoshiga, Kenji Osawa, Shun Nishimura, Takaaki Joujima, Ken-ichi Mochida, Noriaki Kawanabe, Kou Matsuo, Masataka Uehara, Masaaki Sasaguri, Izumi Yoshioka, Kazuhiro Tominaga, Yasuhiro Morimoto

Published in: Oral Radiology | Issue 3/2017

Login to get access

Abstract

Numerous studies, including our own, have revealed that positron emission tomography–computed tomography (PET/CT) using fluorine-18-labeled fluoro-2-deoxy-d-glucose (18F-FDG) is effective for the diagnosis of oral cancers. Large amounts of new information about primary tumors and metastatic lymph nodes have been acquired, and the use of 18F-FDG PET/CT has been shown to improve diagnostic precision in determining both the pathological characteristics of primary oral cancers and the presence of metastatic lymph nodes. However, substantial variations in 18F-FDG uptake in the oral and maxillofacial regions have been identified, and the differential diagnosis of some oral cancers and metastatic lymph nodes remains difficult for radiologists. Therefore, based on the previous research, the aim of the present study was to review the basic and important points regarding the diagnosis of primary oral cancers and metastatic lymph nodes using 18F-FDG PET/CT.
Literature
1.
Kim SJ, Chang S. Volumetric parameters changes of sequential 18F-FDG PET/CT for early prediction of recurrence and death in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy. Clin Nucl Med. 2015;40:930–5.CrossRefPubMed
2.
Wei J, Pei S, Zhu X. Comparison of 18F-FDG PET/CT, MRI and SPECT in the diagnosis of local residual/recurrent nasopharyngeal carcinoma: a meta-analysis. Oral Oncol. 2016;52:11–7.CrossRefPubMed
3.
Müller J, Hüllner M, Strobel K, Huber GF, Burger IA, Haerle SK. The value of (18) F-FDG-PET/CT imaging in oral cavity cancer patients following surgical reconstruction. Laryngoscope. 2015;125:1861–8.CrossRefPubMed
4.
Kito S, Koga H, Kodama M, Habu M, Kokuryo S, Oda M, et al. Alterations in 18F-FDG accumulation into neck-related muscles after neck dissection for patients with oral cancers. Med Oral Patol Oral Cir Bucal. 2016;21:e341–e8.CrossRefPubMedPubMedCentral
5.
Meeuwis J, Hoekstra OS, Witte BI, Boellaard R, Leemans CR, de Bree R. 18FDG SUV in the primary tumor and lymph node metastases is not predictive for development of distant metastases in high risk head and neck cancer patients. Oral Oncol. 2015;51:536–40.CrossRefPubMed
6.
Pasha MA, Marcus C, Fakhry C, Kang H, Kiess AP, Subramaniam RM. FDG PET/CT for management and assessing outcomes of squamous cell cancer of the oral cavity. Am J Roentgenol. 2015;205:W150–W61.CrossRef
7.
Gao S, Li S, Yang X, Tang Q. 18FDG PET-CT for distant metastases in patients with recurrent head and neck cancer after definitive treatment. A meta-analysis. Oral Oncol. 2014;50:163–7.CrossRefPubMed
8.
Xu GZ, Guan DJ, He ZY. (18)FDG-PET/CT for detecting distant metastases and second primary cancers in patients with head and neck cancer. A meta-analysis. Oral Oncol. 2011;47:560–5.CrossRefPubMed
9.
10.
Kito S, Koga H, Kodama M, Yamamoto N, Kokuryo S, Habu M, et al. Reflection of 18F-FDG accumulation in the evaluation of the extent of periapical or periodontal inflammation. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:e62–e9.CrossRefPubMed
11.
Kito S, Koga H, Oda M, Tanaka T, Kodama M, Habu M, et al. The important pitfalls in the diagnosis of cancer in the oral cavity using 18F-FDG-PET-CT. In: Horizons in cancer research. Hauppague: Nova Science Publishers; 2015. pp. 85–96.
12.
Oda M, Tanaka T, Kito S, Seta Y, Ishikawa A, Kodama M, et al. Recent advances of the diagnostic images for oral cancers. In: Oral cancer: causes, diagnosis and treatment. Hauppague: Nova Science Publishers; 2011.
13.
Kowalsky RJ, Falen SW, editors. Radiopharmaceuticals in nuclear pharmacy and nuclear medicine. 2nd ed. Washington, DC: American Pharmacists Association; 2004.
14.
Zhuang H, Alavi A. 18-fluorodeoxyglucose positron emission tomographic imaging in the detection and monitoring of infection and inflammation. Semin Nucl Med. 2002;32:47–59.CrossRefPubMed
15.
Shreve PD, Bui CDH. Normal variants in FDG PET imaging. In: Wahl RL, editor. Principles and practice of positron emission tomography. Philadelphia: Lippincott Williams & Wilkins; 2002. pp. 111–36.
16.
Roh JL, Ryu CH, Choi SH, Kim JS, Lee JH, Cho KJ, et al. Clinical utility of 18F-FDG PET for patients with salivary gland malignancies. J Nucl Med. 2007;48:240–6.PubMed
17.
Islam T, Harisinghani MG. Overview of nanoparticle use in cancer imaging. Cancer Biomark. 2009;5:61–7.CrossRefPubMed
18.
Lee C, Langen KM, Lu W, Haimerl J, Schnarr E, Ruchala KJ, et al. Evaluation of geometric changes of parotid glands during head and neck cancer radiotherapy using daily MVCT and automatic deformable registration. Radiother Oncol. 2008;89:81–8.CrossRefPubMed
19.
Gupta T, Beriwal S. PET/CT-guided radiation therapy planning: from present to the future. Indian J Cancer. 2010;47:126–33.CrossRefPubMed
20.
Roh JL, Yeo NK, Kim JS, Lee JH, Cho KJ, Choi SH, et al. Utility of 2-[18F] fluoro-2-deoxy-d-glucose positron emission tomography and positron emission tomography/computed tomography imaging in the preoperative staging of head and neck squamous cell carcinoma. Oral Oncol. 2007;43:887–93.CrossRefPubMed
21.
Schwartz DL, Ford E, Rajendran J, Yueh B, Coltrera MD, Virgin J, et al. FDG-PET/CT imaging for preradiotherapy staging of head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2005;61:129–36.CrossRefPubMed
22.
Andrade RS, Heron DE, Degirmenci B, Filho PA, Branstetter BF, Seethala RR, et al. Posttreatment assessment of response using FDG-PET/CT for patients treated with definitive radiation therapy for head and neck cancers. Int J Radiat Oncol Biol Phys. 2006;65:1315–22.CrossRefPubMed
23.
Suzuki H, Fukuyama R, Hasegawa Y, Tamaki T, Nishio M, Nakashima T, et al. Tumor thickness, depth of invasion, and Bcl-2 expression are correlated with FDG-uptake in oral squamous cell carcinomas. Oral Oncol. 2009;45:891–7.CrossRefPubMed
24.
Chung MK, Jeong HS, Son YI, So YK, Park GY, Choi JY, et al. Metabolic tumor volumes by [18F]-fluorodeoxyglucose PET/CT correlate with occult metastasis in oral squamous cell carcinoma of the tongue. Ann Surg Oncol. 2009;16:3111–7.CrossRefPubMed
25.
Miyawaki A, Ikeda R, Hijioka H, Ishida T, Ushiyama M, Nozoe E, et al. SUVmax of FDG-PET correlates with the effects of neoadjuvant chemoradiotherapy for oral squamous cell carcinoma. Oncol Rep. 2010;23:1205–12.CrossRefPubMed
26.
Suzuki H, Hasegawa Y, Terada A, Hyodo I, Nakashima T, Nishio M, et al. FDG-PET predicts survival and distant metastasis in oral squamous cell carcinoma. Oral Oncol. 2009;45:569–73.CrossRefPubMed
27.
Kubota K, Yokoyama J, Yamaguchi K, Ono S, Qureshy A, Itoh M, et al. FDG-PET delayed imaging for the detection of head and neck cancer recurrence after radio-chemotherapy: comparison with MRI/CT. Eur J Nucl Med Mol Imaging. 2004;31:590–5.CrossRefPubMed
28.
Krabbe CA, Pruim J, Dijkstra PU, Balink H, van der Laan BF, de Visscher JG, et al. 18F-FDG PET as a routine posttreatment surveillance tool in oral and oropharyngeal squamous cell carcinoma: a prospective study. J Nucl Med. 2009;50:1940–7.CrossRefPubMed
29.
McGarvey AC, Osmotherly PG, Hoffman GR, Chiarelli PE. Scapular muscle exercises following neck dissection surgery for head and neck cancer: a comparative electromyographic study. Phys Ther. 2013;93:786–97.CrossRefPubMed
30.
McGarvey AC, Osmotherly PG, Hoffman GR, Chiarelli PE. Impact of neck dissection on scapular muscle function: a case-controlled electromyographic study. Arch Phys Med Rehabil. 2013;94:113–9.CrossRefPubMed
31.
McGarvey AC, Chiarelli PE, Osmotherly PG, Hoffman GR. Physiotherapy for accessory nerve shoulder dysfunction following neck dissection surgery: a literature review. Head Neck. 2011;33:274–80.CrossRefPubMed
32.
Andreadis D, Stylianou F, Link-Tsatsouli I, Markopoulos A. Bilateral masseter and internal pterygoid muscle hypertrophy: a diagnostic challenge. Med Princ Pract. 2014;23:286–8.CrossRefPubMed
33.
Ariji Y, Fuwa N, Kodaira T, Tachibana H, Nakamura T, Satoh Y, et al. False-positive positron emission tomography appearance with 18F-fluorodeoxyglucose after definitive radiotherapy for cancer of the mobile tongue. Br J Radiol. 2009;82:e3–e7.CrossRefPubMed
34.
Bogsrud TV, Lowe VJ. Normal variants and pitfalls in whole-body PET imaging with 18F FDG. Appl Radiol.0. 2006;35:16–30.
35.
Shimamoto H, Tatsumi M, Kakimoto N, Hamada S, Shimosegawa E, Murakami S, et al. (18)F-FDG accumulation in the oral cavity is associated with periodontal disease and apical periodontitis: an initial demonstration on PET/CT. Ann Nucl Med. 2008;22:587–93.CrossRefPubMed
36.
Abdoli M, Ay MR, Ahmadian A, Zaidi H. A virtual sinogram method to reduce dental metallic implant artefacts in computed tomography-based attenuation correction for PET. Nucl Med Commun. 2010;31:22–31.CrossRefPubMed
37.
Kamel EM, Burger C, Buck A, von Schulthess GK, Goerres GW. Impact of metallic dental implants on CT-based attenuation correction in a combined PET/CT scanner. Eur Radiol. 2003;13:724–8.CrossRefPubMed
38.
Harnsberger HR. Handbook of head and neck imaging. 2nd ed. St. Louis: Mosby-Year Book, Inc; 1994.
39.
Morimoto Y, Tanaka T, Yamamoto N, Kodama M, Seta Y, Habu M, et al. New trends and advances in oral and maxillofacial imaging. Curr Med Imaging Rev. 2009;5:226–37.CrossRef
40.
Liao CT, Wang HM, Chang JT, Lin CY, Ng SH, Huang SF, et al. Influence of pathological nodal status and maximal standardized uptake value of the primary tumor and regional lymph nodes on treatment plans in patients with advanced oral cavity squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2010;77:421–9.CrossRefPubMed
41.
Liao CT, Chang JT, Wang HM, Ng SH, Huang SF, Chen IH, et al. Preoperative [18F]-fluorodeoxyglucose positron emission tomography standardized uptake value of neck lymph nodes may aid in selecting patients with oral cavity squamous cell carcinoma for salvage therapy after relapse. Eur J Nucl Med Mol Imaging. 2009;36:1783–93.CrossRefPubMed
42.
Goerres GW, Schmid DT, Grätz KW, von Schulthess GK, Eyrich GK. Impact of whole body positron emission tomography on initial staging and therapy in patients with squamous cell carcinoma of the oral cavity. Oral Oncol. 2003;39:547–51.CrossRefPubMed
Metadata
Title
Basic and important points regarding the diagnosis of oral cancers using fluorine-18-labeled fluoro-2-deoxy-d-glucose positron emission tomography–computed tomography: a review
Authors
Shinji Kito
Hirofumi Koga
Masafumi Oda
Tatsurou Tanaka
Masaaki Kodama
Manabu Habu
Ikuya Miyamoto
Shinya Kokuryo
Noriaki Yamamoto
Nao Wakasugi-Sato
Shinobu Matsumoto-Takeda
Daigo Yoshiga
Kenji Osawa
Shun Nishimura
Takaaki Joujima
Ken-ichi Mochida
Noriaki Kawanabe
Kou Matsuo
Masataka Uehara
Masaaki Sasaguri
Izumi Yoshioka
Kazuhiro Tominaga
Yasuhiro Morimoto
Publication date
01-09-2017
Publisher
Springer Singapore
Published in
Oral Radiology / Issue 3/2017
Print ISSN: 0911-6028
Electronic ISSN: 1613-9674
DOI
https://doi.org/10.1007/s11282-017-0273-0

Other articles of this Issue 3/2017

Oral Radiology 3/2017 Go to the issue

Original Article

Application of fractal analysis of the midpalatal suture for estimation of pubertal growth spurts

Original Article

Cone-beam computed tomography investigation of crucial mandibular canal variations in Thais

Original Article

Cone-beam computed tomography evaluation of palatogingival grooves: a retrospective study with literature review

Review Article

Upper airway imaging in sleep-disordered breathing: role of cone-beam computed tomography

Original Article

Effects of shade and composition on radiopacity of dental composite restorative materials

Original Article

Clinical significance of intraoral strain elastography for diagnosing early stage tongue carcinoma: a preliminary study