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Oral Radiology
Published in: Oral Radiology 2/2017

01-05-2017 | Original Article

Osteoporotic mandibular changes caused by type 2 diabetes mellitus: a comparative study by cone beam computed tomography imaging

Authors: Saadettin Kayipmaz, Saliha Akçay, Ömer Said Sezgin

Published in: Oral Radiology | Issue 2/2017

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Abstract

Objectives

Studies on bone mineral density and fracture risk in diabetic patients have attracted interest in the last few years. This study was aimed at comparing mandibular osteoporotic changes assessed by qualitative and quantitative radiographic methods in the mandibles of type 2 diabetes mellitus patients with those of non-diabetic subjects using cone beam computed tomographic images.

Methods

This quantitative and qualitative study of mandibular bone in diabetic patients included 23 type 2 diabetes mellitus patients and an equal number of healthy subjects. Radiomorphometric measurements were performed for each subject using cone beam computed tomography images. Changes in cortical bone thickness were determined by measuring bone area. Fractal dimension analysis was applied to evaluate the trabecular structure of the bone.

Results

No statistically significant difference could be established between the type 2 diabetes mellitus group and the control group in regard to either radiomorphometric measurements or fractal dimension analysis. Quantitative assessment of mandibular bone indicated a thinning of the cortical bone, with a statistically significant difference between the type 2 diabetes mellitus patients and the healthy controls.

Conclusions

Bone condition related to diabetes involves complex pathophysiological mechanisms; thus, radiographic imaging parameters may be useful as an adjunct to clinical parameters.
Literature
1.
Abdulameer SA, Sulaiman SA, Hassali MA, Subramaniam K, Sahib MN. Osteoporosis and type 2 diabetes mellitus: what do we know, and what we can do? Patient Prefer Adher. 2012;6:435–48.CrossRef
2.
Leidig-Bruckner G, Grobholz S, Bruckner T, Scheidt-Nave C, Nawroth P, Schneider JG. Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus. BMC Endocr Disord. 2014;11:14–33.
3.
Zhou Y, Li Y, Zhang D, Wang J, Yang H. Prevalence and predictors of osteopenia and osteoporosis in postmenopausal Chinese women with type 2 diabetes. Diabetes Res Clin Pract. 2010;90:261–9.CrossRefPubMed
4.
Ma L, Oei L, Jiang L, Estrada K, Chen H, Wang Z, et al. Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies. Eur J Epidemiol. 2012;27:319–32.CrossRefPubMedPubMedCentral
5.
Ay S, Gursoy UK, Erselcan T, Marakoglu İ. Assessment of mandibular bone mineral density in patients with type 2 diabetes mellitus. Dentomaxillofac Radiol. 2005;34:327–31.CrossRefPubMed
6.
Onoyama K, Kawatama R, Kozai Y, Sakurai T, Kashima I. Comparison of mandibular trabecular structures between normal and diabetic rats: evaluation of spontaneous type 2 diabetes in a rat model. Oral Radiol. 2011;27:35–42.CrossRef
7.
Taguchi A, Suei Y, Ohtsuka M, Otani K, Tanimoto K, Ohtaki M. Usefulness of panoramic radiography in the diagnosis of postmenopausal osteoporosis in women. Width and morphology of inferior cortex of the mandible. Dentomaxillofac Radiol. 1996;25:263–7.CrossRefPubMed
8.
Dagistan S, Bilge OM. Comparison of antegonial index, mental index, panoramic mandibular index and mandibular cortical index values in the panoramic radiographs of normal males and male patients with osteoporosis. Dentomaxillofac Radiol. 2010;39:290–4.CrossRefPubMedPubMedCentral
9.
10.
Sahin B, Acer N, Sonmez OF, Emirzeoglu M, Basaloglu H, Uzun A, et al. Comparison of four methods for the estimation of intracranial volume: a gold standard study. Clin Anat. 2007;20:766–73.CrossRefPubMed
11.
Bayram M, Kayipmaz S, Sezgin OS, Küçük M. Volumetric analysis of the mandibular condyle using cone beam computed tomography. Eur J Radiol. 2012;81:1812–6.CrossRefPubMed
12.
Koh KJ, Kim KA. Utility of the computed tomography indices on cone beam computed tomography images in the diagnosis of osteoporosis in women. Imaging Sci Dent. 2011;41:101–6.CrossRefPubMedPubMedCentral
13.
White SC, Rudolph DJ. Alterations of the trabecular pattern of the jaws in patients with osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88:628–35.CrossRefPubMed
14.
Klemetti E, Kolmakov S, Kroger H. Pantomography in assessment of the osteoporosis risk group. Scand J Dent Res. 1994;102:68–72.PubMed
15.
Sahin B, Ergur H. Assessment of the optimum section thickness for the estimation of liver volume using magnetic resonance images: a stereological gold standard study. Eur J Radiol. 2006;57:96–101.CrossRefPubMed
16.
Gaalaas L, Henn L, Gaillard PR, Ahmad M, Islam MS. Analysis of trabecular bone using site-specific fractal values calculated from cone beam CT images. Oral Radiol. 2014;30:179–85.CrossRef
17.
Anaforoglu I, Nar-Demirer A, Bascil-Tutuncu N, Ertorer ME. Prevalence of osteoporosis and factors affecting bone mineral density among postmenopausal Turkish women with type 2 diabetes. J Diabetes Complicat. 2009;23:12–7.CrossRefPubMed
18.
Sosa M, Dominguez M, Navarro MC, Segarra MC, Hernández D, de Pablos P, et al. Bone mineral metabolism is normal in non-insulin-dependent diabetes mellitus. J Diabetes Complicat. 1996;10:201–5.CrossRefPubMed
19.
Hofbauer LC, Brueck CC, Singh SK, Dobnig H. Osteoporosis in patients with diabetes mellitus. J Bone Miner Res. 2007;22:1317–28.CrossRefPubMed
20.
Taguchi A, Ohtsuka M, Tsuda M, Nakamoto T, Kodama I, Inagaki K, et al. Risk of vertebral osteoporosis in post-menopausal women with alterations of the mandible. Dentomaxillofac Radiol. 2007;36:143–8.CrossRefPubMed
21.
Devlin H, Karayianni K, Mitsea A, Jacobs R, Lindh C, van der Stelt P, et al. Diagnosing osteoporosis by using dental panoramic radiographs: the OSTEODENT project. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:821–8.CrossRefPubMed
22.
Gulsahi A, Paksoy CS, Ozden S, Kucuk NO, Cebeci AR, Genc Y. Assessment of bone mineral density in the jaws and its relationship to radiomorphometric indices. Dentomaxillofac Radiol. 2010;39:284–9.CrossRefPubMedPubMedCentral
23.
Taguchi A, Suei Y, Sanada M, Ohtsuka M, Nakamoto T, Sumida H, et al. Validation of dental panoramic radiography measures for identifying postmenopausal women with spinal osteoporosis. Am J Roentgenol. 2004;183:1755–60.CrossRef
24.
Ostenson CG, Fière V, Ahmed M, Lindström P, Brismar K, Brismar T, et al. Decreased cortical bone thickness in spontaneously non-insulin-dependent diabetic GK rats. J Diabetes Complicat. 1997;11:319–22.CrossRefPubMed
25.
Mishima T, Motoyama K, Imanishi Y, Hamamoto K, Nagata Y, Yamada S, et al. Decreased cortical thickness, as estimated by a newly developed ultrasound device, as a risk for vertebral fracture in type 2 diabetes mellitus patients with eGFR of less than 60 mL/min/1.73 m2. Osteoporos Int. 2015;26:229–36.CrossRefPubMed
26.
Naitoh M, Kurosu Y, Inagaki K, Katsumata A, Noguchi T, Ariji E. Assessment of mandibular buccal and lingual cortical bones in postmenopausal women. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:545–50.CrossRefPubMed
27.
Kayipmaz S, Sezgin OS, Saricaoglu ST, Bas O, Sahin B, Küçük M. The estimation of the volume of sheep mandibular defects using cone-beam computed tomography images and a stereological method. Dentomaxillofac Radiol. 2011;40:165–9.CrossRefPubMedPubMedCentral
28.
Paccou J, Ward KA, Jameson KA, Dennison EM, Cooper C, Edwards MH. Bone microarchitecture in men and women with diabetes: the importance of cortical porosity. Calcif Tissue Int. 2016;98(5):465–73.CrossRefPubMed
29.
Patsch JM, Burghardt AJ, Yap SP, Baum T, Schwartz AV, Joseph GB, et al. Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures. J Bone Miner Res. 2013;28:313–24.CrossRefPubMedPubMedCentral
30.
Oliveira ML, Pedrosa EF, Cruz AD, Haiter-Neto F, Paula FJ, Watanabe PC. Relationship between bone mineral density and trabecular bone pattern in postmenopausal osteoporotic Brazilian women. Clin Oral Investig. 2013;17:1847–53.CrossRefPubMed
31.
Yaşar F, Akgünlü F. The differences in panoramic mandibular indices and fractal dimension between patients with and without spinal osteoporosis. Dentomaxillofac Radiol. 2006;35:1–9.CrossRefPubMed
32.
Roberts M, Yuan J, Graham J, Jacobs R, Devlin H. Changes in mandibular cortical width measurements with age in men and women. Osteoporos Int. 2011;22:1915–25.CrossRefPubMed
33.
Ledgerton D, Horner K, Devlin H, Worthington H. Radiomorphometric indices of the mandible in a British female population. Dentomaxillofac Radiol. 1999;28:173–81.CrossRefPubMed
34.
Ling H, Yang X, Li P, Megalooikonomou V, Xu Y, Yang J. Cross gender–age trabecular texture analysis in cone beam CT. Dentomaxillofac Radiol. 2014;43:20130324.CrossRefPubMedPubMedCentral
Metadata
Title
Osteoporotic mandibular changes caused by type 2 diabetes mellitus: a comparative study by cone beam computed tomography imaging
Authors
Saadettin Kayipmaz
Saliha Akçay
Ömer Said Sezgin
Publication date
01-05-2017
Publisher
Springer Singapore
Published in
Oral Radiology / Issue 2/2017
Print ISSN: 0911-6028
Electronic ISSN: 1613-9674
DOI
https://doi.org/10.1007/s11282-016-0252-x

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