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International Urology and Nephrology

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01-10-2019 | Kidney Injury | Urology - Original Paper

Evaluation of the urinary podocalyxin and nephrin excretion levels to determine a safe time interval between two sessions of SWL for renal stones: a non randomized exploratory study

Authors: Hüseyin Kocatürk, Nursen Atasoy, Fevzi Bedir, İbrahim Karabulut, Engin Şebin, Kemal Sarica

Published in: International Urology and Nephrology | Issue 10/2019

Abstract

Objectives

We aimed to evaluate the role of nephrin and podocalyxin in determining the intervals between shock wave lithotripsy (SWL) sessions and how soon the kidney damage was recovered.

Methods

This work was a prospective study that included 30 patients with unilateral kidney stones. The patients’ midflow urine samples were collected before SWL and 1 h, 1 day and 1 week after the procedure. Nephrin and podocalyxin levels in the urine samples were measured by the enzyme-linked immunosorbent assay method.

Results

Among the 30 patients who underwent SWL, 19 were males and 11 were females. The mean age of the SWL group was 34.7 ± 13.2. Both biomarkers did not correlate with age, creatinine values, body mass index, stone side, stone size, energy, frequency and shock numbers. Nephrin and podocalyxin levels were significantly higher at the pre-SWL point (p < 0.05). After the procedure, a significant decrease was observed in both biomarker levels (p < 0.05). At the end of first day, these levels started to increase progressively up to the end of the first week (p > 0.05).

Conclusions

Nephrin and podocalyxin may help to determine early period kidney damage associated with SWL. Post-SWL podocalyxin and nephrin values may be used to determine the interval between SWL sessions.

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Title: Evaluation of the urinary podocalyxin and nephrin excretion levels to determine a safe time interval between two sessions of SWL for renal stones: a non randomized exploratory study
Authors: Hüseyin Kocatürk
Nursen Atasoy
Fevzi Bedir
İbrahim Karabulut
Engin Şebin
Kemal Sarica
Publication date: 01-10-2019
Publisher: Springer Netherlands
Keywords: Kidney Injury
Shock
Shock
Published in: International Urology and Nephrology / Issue 10/2019
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-019-02229-8

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Evaluation of the urinary podocalyxin and nephrin excretion levels to determine a safe time interval between two sessions of SWL for renal stones: a non randomized exploratory study

Abstract

Objectives

Methods

Results

Conclusions

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Abstract

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