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01-11-2018 | Nephrology - Original Paper

Decreased percentage of memory B cells is independently associated with increased susceptibility to infection in patients on maintenance hemodialysis

Authors: Man Guo, Rongyi Chen, Fangfang Xiang, Xuesen Cao, Jiachang Hu, Zhihui Lu, Shaomin Gong, Xiaohong Chen, Xiao Chen, Xiaoqiang Ding, Bo Shen, Jianzhou Zou

Published in: International Urology and Nephrology | Issue 11/2018

Abstract

Purpose

Infection is a common complication and cause of death in patients on maintenance hemodialysis (MHD). B lymphocytes, which are an important component of the immune system, play a significant role in defending against pathogen invasion. However, in patients on MHD, the connection between infection and B cell subsets remains largely unknown. Our study aims to clarify the potential role of the distribution of B cell subsets in the infection process in patients on MHD.

Methods

In this cross-sectional study, basic information was collected from 175 patients on MHD from July 2016 to July 2017 at Zhongshan Hospital, Fudan University. The distributions of the B cell subsets in patients with and without infection were analyzed using flow cytometry to determine the role of B lymphocyte subsets in the infection process in patients on MHD.

Results

Among the 175 patients, 45 suffered from infection. The respiratory tract was the most common infection site, accounting for 67.86% of all infections. After adjustment using multivariate logistic regression models, memory B cells [per 1% increase, odds ratio [95% confidence interval (CI)]: 0.949 (0.915, 0.984), P < 0.01], switched memory B cells [per 1% increase, odds ratio (95% CI): 0.939 (0.898, 0.982), P < 0.01], naïve B cells [per 1% increase, odds ratio (95% CI): 1.042 (1.009, 1.075), P < 0.05] and IgG titers [per 1 g/L increase, odds ratio (95% CI): 0.779 (0.630, 0.963), P < 0.05] were independent risk factors for infection in dialysis patients.

Conclusion

A decrease in memory B cells is independently associated with an increased risk of infection in patients on dialysis.

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Title: Decreased percentage of memory B cells is independently associated with increased susceptibility to infection in patients on maintenance hemodialysis
Authors: Man Guo
Rongyi Chen
Fangfang Xiang
Xuesen Cao
Jiachang Hu
Zhihui Lu
Shaomin Gong
Xiaohong Chen
Xiao Chen
Xiaoqiang Ding
Bo Shen
Jianzhou Zou
Publication date: 01-11-2018
Publisher: Springer Netherlands
Published in: International Urology and Nephrology / Issue 11/2018
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-018-1977-8

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Decreased percentage of memory B cells is independently associated with increased susceptibility to infection in patients on maintenance hemodialysis

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Purpose

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Conclusion

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