Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
International Urology and Nephrology
Published in: International Urology and Nephrology 5/2018

01-05-2018 | Nephrology - Original Paper

Cigarette smoking and risk of albuminuria in patients with type 2 diabetes: a systematic review and meta-analysis of observational studies

Authors: Haili Xu, Jinliu Suo, Jing Lian

Published in: International Urology and Nephrology | Issue 5/2018

Login to get access

Abstract

Background

The aim of this study was to assess the effects of smoking on albuminuria risk in adults with type 2 diabetes mellitus (T2DM).

Methods

A literature search was conducted using MEDLINE, EMBASE, and China National Knowledge Infrastructure from the established date to October 2017. Summary relative risks (SRR) and 95% confidence intervals (CI) were computed utilizing a random effect inverse variance method.

Results

This meta-analysis included a total of 19 relevant observational studies (four prospective cohort, seven case–control, and eight cross-sectional studies), reporting 105,031 participants and 23,366 albuminuria events. Compared with never-smokers with T2DM, the SRRs of albuminuria were 1.43 (95% CIs 1.27–1.61) for ever-smokers, 2.61 (95% CIs 1.86–3.64) for current smokers, and 1.86 (95% CIs 1.37–2.52) for former smokers. Considerable heterogeneity was observed among these studies, and study design was a significant modifier for this association. There were significantly elevated risk associations for microalbuminuria (SRRs = 1.24, 95% CIs 1.05–1.46) and for macroalbuminuria (SRRs = 1.65, 95% CIs 1.03–2.66), respectively.

Conclusions

Our systematic review and meta-analysis indicates that cigarette smoking might be a potential factor for the development of albuminuria in adults with T2DM. Future studies are required to investigate the association between smoking cessation and intensity and incident albuminuria in adults with T2DM.
Appendix
Available only for authorised users
Literature
1.
Keen H, Chlouverakis C, Fuller J et al (1969) The consomitants of raised blood sugar: studies in newly-detected hyperglycaemics. II. Urinary albumin excretion, blood pressure and their relation to blood sugar levels. Guys Hosp Rep 118(2):247–254PubMed
2.
Viberti GC, Hill RD, Jarrett RJ et al (1982) Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet 1(8287):1430–1432CrossRefPubMed
3.
Mogensen CE (1984) Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med 310(6):356–360CrossRefPubMed
4.
Bakris GL, Molitch M (2014) Microalbuminuria as a risk predictor in diabetes: the continuing saga. Diabetes Care 37(3):867–875CrossRefPubMed
5.
Tebbe U, Bramlage P, Thoenes M et al (2009) Prevalence of microalbuminuria and its associated cardiovascular risk: German and Swiss results of the recent global i-SEARCH survey. Swiss Med Wkly 139(33–34):473–480PubMed
6.
Ahn JH, Yu JH, Ko SH et al (2014) Prevalence and determinants of diabetic nephropathy in Korea: Korea national health and nutrition examination survey. Diabetes Metab J 38(2):109–119CrossRefPubMedPubMedCentral
7.
Thompson JL, Allen P, Cunningham-Sabo L et al (2002) Environmental, policy, and cultural factors related to physical activity in sedentary American Indian women. Women Health 36(2):59–74CrossRefPubMed
8.
Radcliffe NJ, Seah JM, Clarke M et al (2017) Clinical predictive factors in diabetic kidney disease progression. J Diabetes Investig 8(1):6–18CrossRefPubMed
9.
Xue R, Gui D, Zheng L et al (2017) Mechanistic insight and management of diabetic nephropathy: recent progress and future perspective. J Diabetes Res 2017:1839809CrossRefPubMedPubMedCentral
10.
Linneberg A, Jacobsen RK, Skaaby T et al (2015) Effect of smoking on blood pressure and resting heart rate: a mendelian randomization meta-analysis in the CARTA consortium. Circ Cardiovasc Genet 8(6):832–841CrossRefPubMedPubMedCentral
11.
Li WH, Wang MP, Lam TH et al (2017) Brief intervention to promote smoking cessation and improve glycemic control in smokers with type 2 diabetes: a randomized controlled trial. Sci Rep 7:45902CrossRefPubMedPubMedCentral
12.
Yeom H, Lee JH, Kim HC et al (2016) The association between smoking tobacco after a diagnosis of diabetes and the prevalence of diabetic nephropathy in the Korean male population. J Prev Med Public Health 49(2):108–117CrossRefPubMedPubMedCentral
13.
Zhang W, Yang Z, Li X et al (2015) The functional Q84R polymorphism of TRIB3 gene is associated with diabetic nephropathy in Chinese type 2 diabetic patients. Gene 555(2):357–361CrossRefPubMed
14.
Furukawa S, Yamamoto S, Todo Y et al (2014) Association between subclinical hypothyroidism and diabetic nephropathy in patients with type 2 diabetes mellitus. Endocr J 61(10):1011–1018CrossRefPubMed
15.
Wolf G, Busch M, Muller N et al (2011) Association between socioeconomic status and renal function in a population of German patients with diabetic nephropathy treated at a tertiary centre. Nephrol Dial Transplant 26(12):4017–4023CrossRefPubMed
16.
Hsu CC, Hwang SJ, Tai TY et al (2010) Cigarette smoking and proteinuria in Taiwanese men with Type 2 diabetes mellitus. Diabet Med 27(3):295–302CrossRefPubMed
17.
Parving HH, Lewis JB, Ravid M et al (2006) Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients: a global perspective. Kidney Int 69(11):2057–2063CrossRefPubMed
18.
Hou XH, Wang JH, Feng P et al (2005) A case control study on the risk factors of proteinuria in patients with type 2 diabetes. Zhonghua Liu Xing Bing Xue Za Zhi 26(1):39–43PubMed
19.
Herrera-Pombo JL, Aguilar-Diosdado M, Hawkins F et al (2005) Is increasing urinary albumin a better marker for microvascular than for macrovascular complication of type 2 diabetes mellitus? Nephron Clin Pract 101(3):c116–c121CrossRefPubMed
20.
Cederholm J, Eliasson B, Nilsson PM et al (2005) Microalbuminuria and risk factors in type 1 and type 2 diabetic patients. Diabetes Res Clin Pract 67(3):258–266CrossRefPubMed
21.
Tam TK, Cheng LP, Lau DM et al (2004) The prevalence of microalbuminuria among patients with type II diabetes mellitus in a primary care setting: cross-sectional study. Hong Kong Med J 10(5):307–311PubMed
22.
Kohler KA, McClellan WM, Ziemer DC et al (2002) Smoking and microalbuminuria: a case-control study in African-Americans with type 2 diabetes. Diabetes Care 25(1):243–245CrossRefPubMed
23.
Pijls LT, de Vries H, Kriegsman DM et al (2001) Determinants of albuminuria in people with Type 2 diabetes mellitus. Diabetes Res Clin Pract 52(2):133–143CrossRefPubMed
24.
Yokoyama H, Okudaira M, Otani T et al (1998) High incidence of diabetic nephropathy in early-onset Japanese NIDDM patients. Risk analysis. Diabetes Care. 21(7):1080–1085CrossRefPubMed
25.
Klein R, Klein BE, Moss SE et al (1995) Ten-year incidence of gross proteinuria in people with diabetes. Diabetes 44(8):916–923CrossRefPubMed
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
Stroup DF, Berlin JA, Morton SC et al (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 283(15):2008–2012CrossRefPubMed
36.
Ovbiagele B (2008) Microalbuminuria: risk factor and potential therapeutic target for stroke? J Neurol Sci 271(1–2):21–28CrossRefPubMed
37.
38.
39.
Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088–1101CrossRefPubMed
40.
41.
Chen Y, Zhi Y, Li C et al (2016) HDL cholesterol and risk of diabetic nephropathy in patient with type 1 diabetes: a meta-analysis of cohort studies. Diabetes Res Clin Pract 122:84–91CrossRefPubMed
42.
Barua RS, Ambrose JA (2013) Mechanisms of coronary thrombosis in cigarette smoke exposure. Arterioscler Thromb Vasc Biol 33(7):1460–1467CrossRefPubMed
43.
Caimi G, Hopps E, Montana M et al (2014) Nitric oxide metabolites (nitrite and nitrate) in several clinical condition. Clin Hemorheol Microcirc. 56(4):359–369PubMed
44.
Salvatore SP, Troxell ML, Hecox D et al (2015) Smoking-related glomerulopathy: expanding the morphologic spectrum. Am J Nephrol 41(1):66–72CrossRefPubMed
45.
Baggio B, Budakovic A, Dalla Vestra M et al (2002) Effects of cigarette smoking on glomerular structure and function in type 2 diabetic patients. J Am Soc Nephrol 13(11):2730–2736CrossRefPubMed
46.
Jose MJ, Varkey V, Chandni R et al (2016) The Role of Smoking as a Modifiable Risk Factor in Diabetic Nephropathy. J Assoc Physicians India 64(7):34–38PubMed
47.
Lan L, Han Y, Ren W et al (2015) Advanced glycation endproducts affect the cytoskeletal structure of rat glomerular endothelial cells via the Rasrelated C3 botulinum toxin substrate 1 signaling pathway. Mol Med Rep. 11(6):4321–4326CrossRefPubMed
48.
Pala L, Cresci B, Manuelli C et al (2005) Vascular endothelial growth factor receptor-2 and low affinity VEGF binding sites on human glomerular endothelial cells: biological effects and advanced glycosilation end products modulation. Microvasc Res 70(3):179–188CrossRefPubMed
49.
Chuahirun T, Simoni J, Hudson C et al (2004) Cigarette smoking exacerbates and its cessation ameliorates renal injury in type 2 diabetes. Am J Med Sci 327(2):57–67CrossRefPubMed
50.
51.
Launay JM, Del Pino M, Chironi G et al (2009) Smoking induces long-lasting effects through a monoamine-oxidase epigenetic regulation. PLoS ONE 4(11):e7959CrossRefPubMedPubMedCentral
52.
Hellemons ME, Agarwal PK, van der Bij W et al (2011) Former smoking is a risk factor for chronic kidney disease after lung transplantation. Am J Transplant 11(11):2490–2498CrossRefPubMed
53.
Bowlin SJ, Morrill BD, Nafziger AN et al (1996) Reliability and changes in validity of self-reported cardiovascular disease risk factors using dual response: the behavioral risk factor survey. J Clin Epidemiol 49(5):511–517CrossRefPubMed
54.
Metadata
Title
Cigarette smoking and risk of albuminuria in patients with type 2 diabetes: a systematic review and meta-analysis of observational studies
Authors
Haili Xu
Jinliu Suo
Jing Lian
Publication date
01-05-2018
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 5/2018
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-018-1825-x

Other articles of this Issue 5/2018

International Urology and Nephrology 5/2018 Go to the issue

Urology - Letter to the Editor

Re: Lebentrau S, Gilfrich C, Vetterlein MW, Schumacher H, Spachmann PJ, Brookman-May SD, Fritsche HM, Schostak M, Wagenlehner F, Burger M, May M, MR2 study group (2017) Impact of the medical specialty on knowledge regarding multidrug-resistant organisms and strategies toward antimicrobial stewardship. Int Urol Nephrol 49:1311–1318

Nephrology - Original Paper

Knocking down Cabin1 induces glomerular podocyte injury

Nephrology - Original Paper

Prognostic value of cardiovascular calcifications in hemodialysis patients: a longitudinal study

Urology - Original Paper

Chemokine CXCL3 mediates prostate cancer cells proliferation, migration and gene expression changes in an autocrine/paracrine fashion

Nephrology - Original Paper

Prediction of hemodialysis vascular access failure using segmental bioimpedance analysis parameters

Nephrology - Review

The role of zinc in urinary stone disease
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits