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International Urology and Nephrology

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01-03-2018 | Nephrology - Original Paper

Factors associated with calcium requirements after parathyroidectomy in chronic kidney disease patients

Authors: Yue Ding, Hongying Wang, Qiang Zou, Yiting Jin, Zijing Zhang, Junwen Huang

Published in: International Urology and Nephrology | Issue 3/2018

Abstract

Background

Renal hyperparathyroidism is a common complication of chronic kidney disease (CKD). Parathyroidectomy (PTX) for these patients continues to be a valuable option in the era of calcimimetics. Postoperative hypocalcemia is common after surgery. The aim of this study was to identify clinical factors to define postoperative calcium requirements.

Methods

From February 2013 to May 2017, 68 patients with chronic kidney disease 5 (CKD5) who underwent PTX were reviewed. We collected clinical and laboratory data preoperatively and calculated the total calcium requirement in a week after surgery. Univariate and multiple analyses were performed to study whether these clinical and laboratory factors were associated with calcium requirement.

Results

Univariate analysis showed that preoperative alkaline phosphatase (ALP), calcium (Ca), parathyroid hormone and hemoglobin were independently associated with calcium requirement. Multivariate model showed that the preoperative ALP was the only independent factor that could predict the requirement of calcium.

Conclusions

In the context of a high dCa (1.75 mmol/l) and a stable dose of calcitriol, preoperative ALP levels were significantly associated with calcium requirement in patients with CKD5 undergoing PTX.

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Title: Factors associated with calcium requirements after parathyroidectomy in chronic kidney disease patients
Authors: Yue Ding
Hongying Wang
Qiang Zou
Yiting Jin
Zijing Zhang
Junwen Huang
Publication date: 01-03-2018
Publisher: Springer Netherlands
Published in: International Urology and Nephrology / Issue 3/2018
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-017-1759-8

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