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International Urology and Nephrology

Published in:

01-03-2016 | Urology - Original Paper

Elevated levels of S100A12 in the seminal plasma of infertile men with varicocele

Authors: Vahid Bagheri, Gholamhossein Hassanshahi, Masoud Zeinali, Mehdi Abedinzadeh, Hossein Khorramdelazad

Published in: International Urology and Nephrology | Issue 3/2016

Abstract

Purpose

Varicocele is among the leading causes of male infertility. Despite decades of research, its pathogenesis is still unclear. S100A12 is a member of the S100 family of calcium-binding proteins with principal extracellular activities. It is secreted by activated neutrophils and interacts with the multiligand receptor for advanced glycation end products (RAGE). Many studies have delineated the patterns of S100A12 expression in a variety of pathologic conditions. These data show that S100A12 could be a potentially useful inflammatory marker. To explore the relationship between S100A12 and infertility, we examined the amount of S100A12 in semen of infertile men who suffered from varicocele.

Methods

S100A12 levels in seminal plasma of 68 infertile men with varicocele (age range 30–45 years) and 68 healthy fertile controls were measured using ELISA. Statistical analysis was performed using both parametric and nonparametric tests.

Results

Results of this study showed that the seminal levels of S100A12 were significantly increased in infertile men with varicocele when compared to fertile controls (P < 0.001).

Conclusions

Because of the important role(s) of these molecules in inflammatory response of cell systems, it could be possible that the spermatozoa motility is reduced following increasing neutrophils, S100A12, and reactive oxygen species in semen of infertile patients with varicocele. S100 proteins seem to be potential biomarkers and therapeutic targets for male infertility.

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Title: Elevated levels of S100A12 in the seminal plasma of infertile men with varicocele
Authors: Vahid Bagheri
Gholamhossein Hassanshahi
Masoud Zeinali
Mehdi Abedinzadeh
Hossein Khorramdelazad
Publication date: 01-03-2016
Publisher: Springer Netherlands
Published in: International Urology and Nephrology / Issue 3/2016
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-015-1188-5

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Elevated levels of S100A12 in the seminal plasma of infertile men with varicocele

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Purpose

Methods

Results

Conclusions

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