Skip to main content
Top
Published in: International Urology and Nephrology 8/2015

01-08-2015 | Urology - Original Paper

Cost of illness of medically treated benign prostatic hyperplasia in Hungary

Authors: Fanni Rencz, Ágnes Kovács, Valentin Brodszky, László Gulácsi, Zalán Németh, Gábor János Nagy, János Nagy, István Buzogány, Géza Böszörményi-Nagy, Attila Majoros, Péter Nyirády

Published in: International Urology and Nephrology | Issue 8/2015

Login to get access

Abstract

Objective

To perform a cost of illness study in lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH) in Hungary.

Methods

A multicentre, cross-sectional survey was carried out in 2014. BPH patients who had never undergone prostate surgery were recruited to the study. EQ-5D and the International Prostate Symptom Score (IPSS) were used to evaluate health status and disease severity. All resource utilisations related to BPH in the past 12 months were recorded. Cost analysis was performed from societal perspective.

Results

Overall, 246 patients were included with mean age of 70.6 (SD 8.1) years. Mean EQ-5D and IPSS were 0.85 (SD 0.19) and 12.8 (SD 6.3). Total annual per patient cost of BPH amounted to €876 (SD €1829). Distribution of the costs between direct medical, direct non-medical and indirect cost was 46, 31 and 23 %. High costs were related to informal care (€243), medications (€178) and private physician visits (€132). Patients missed from work on average 14 h/year and 20 h/year due to absenteeism and presenteeism. Clinical severity expressed in IPSS score was found the strongest predictor of higher total costs (r = 0.429, p < 0.001). Mean costs of mild, moderate and severe patients were €203, €754 and €2168, respectively.

Conclusions

To our knowledge, this is the first study in the literature that assessed indirect costs related to presenteeism in BPH. We found that costs of reduced productivity while working exceed costs of absence from work. As the retirement age is gradually increasing, the importance of presenteeism is getting more significant, especially in pursuit of sustainable employment.
Literature
3.
go back to reference Boncz I, Vajda R, Agoston I, Endrei D, Sebestyen A (2014) Changes in the health status of the population of Central and Eastern European countries between 1990 and 2010. Eur J Health Econ HEPAC 15(Suppl 1):S137–S141. doi:10.1007/s10198-014-0602-8 PubMedCrossRef Boncz I, Vajda R, Agoston I, Endrei D, Sebestyen A (2014) Changes in the health status of the population of Central and Eastern European countries between 1990 and 2010. Eur J Health Econ HEPAC 15(Suppl 1):S137–S141. doi:10.​1007/​s10198-014-0602-8 PubMedCrossRef
4.
go back to reference Speakman M, Kirby R, Doyle S, Ioannou C (2014) Burden of male lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH)—focus on the UK. BJU Int. doi:10.1111/bju.12745 PubMed Speakman M, Kirby R, Doyle S, Ioannou C (2014) Burden of male lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH)—focus on the UK. BJU Int. doi:10.​1111/​bju.​12745 PubMed
5.
go back to reference Rencz F (2012) A jóindulatú prosztata-megnagyobbodás egészség-gazdaságtani elemzése. Köz-Gazdaság 7(3):135–151 Rencz F (2012) A jóindulatú prosztata-megnagyobbodás egészség-gazdaságtani elemzése. Köz-Gazdaság 7(3):135–151
8.
go back to reference Nickel JC (2006) The economics of medical therapy for lower urinary tract symptoms associated with benign prostatic hyperplasia. Curr Urol Rep 7(4):282–287PubMedCrossRef Nickel JC (2006) The economics of medical therapy for lower urinary tract symptoms associated with benign prostatic hyperplasia. Curr Urol Rep 7(4):282–287PubMedCrossRef
9.
go back to reference van Exel NJ, Koopmanschap MA, McDonnell J, Chapple CR, Berges R, Rutten FF (2006) Medical consumption and costs during a one-year follow-up of patients with LUTS suggestive of BPH in six european countries: report of the TRIUMPH study. Eur Urol 49(1):92–102. doi:10.1016/j.eururo.2005.09.016 PubMedCrossRef van Exel NJ, Koopmanschap MA, McDonnell J, Chapple CR, Berges R, Rutten FF (2006) Medical consumption and costs during a one-year follow-up of patients with LUTS suggestive of BPH in six european countries: report of the TRIUMPH study. Eur Urol 49(1):92–102. doi:10.​1016/​j.​eururo.​2005.​09.​016 PubMedCrossRef
10.
go back to reference Gulacsi L, Rotar AM, Niewada M, Loblova O, Rencz F, Petrova G, Boncz I, Klazinga NS (2014) Health technology assessment in Poland, the Czech Republic, Hungary, Romania and Bulgaria. Eur J Health Econ HEPAC 15(Suppl 1):13–25. doi:10.1007/s10198-014-0590-8 CrossRef Gulacsi L, Rotar AM, Niewada M, Loblova O, Rencz F, Petrova G, Boncz I, Klazinga NS (2014) Health technology assessment in Poland, the Czech Republic, Hungary, Romania and Bulgaria. Eur J Health Econ HEPAC 15(Suppl 1):13–25. doi:10.​1007/​s10198-014-0590-8 CrossRef
11.
go back to reference EuroQol G (1990) EuroQol—a new facility for the measurement of health-related quality of life. Health Policy 16(3):199–208CrossRef EuroQol G (1990) EuroQol—a new facility for the measurement of health-related quality of life. Health Policy 16(3):199–208CrossRef
12.
13.
go back to reference Barry MJ, Fowler FJ Jr, O’Leary MP, Bruskewitz RC, Holtgrewe HL, Mebust WK, Cockett AT (1992) The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association. J Urol 148(5):1549–1557PubMed Barry MJ, Fowler FJ Jr, O’Leary MP, Bruskewitz RC, Holtgrewe HL, Mebust WK, Cockett AT (1992) The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association. J Urol 148(5):1549–1557PubMed
14.
go back to reference Reilly MC, Zbrozek AS, Dukes EM (1993) The validity and reproducibility of a work productivity and activity impairment instrument. PharmacoEconomics 4(5):353–365PubMedCrossRef Reilly MC, Zbrozek AS, Dukes EM (1993) The validity and reproducibility of a work productivity and activity impairment instrument. PharmacoEconomics 4(5):353–365PubMedCrossRef
20.
go back to reference Braakman-Jansen LM, Taal E, Kuper IH, van de Laar MA (2012) Productivity loss due to absenteeism and presenteeism by different instruments in patients with RA and subjects without RA. Rheumatology (Oxford) 51(2):354–361. doi:10.1093/rheumatology/ker371 CrossRef Braakman-Jansen LM, Taal E, Kuper IH, van de Laar MA (2012) Productivity loss due to absenteeism and presenteeism by different instruments in patients with RA and subjects without RA. Rheumatology (Oxford) 51(2):354–361. doi:10.​1093/​rheumatology/​ker371 CrossRef
22.
go back to reference Szende A, Nemeth R (2003) Health-related quality of life of the Hungarian population. Orv Hetil 144(34):1667–1674PubMed Szende A, Nemeth R (2003) Health-related quality of life of the Hungarian population. Orv Hetil 144(34):1667–1674PubMed
24.
go back to reference Fourcade RO, Lacoin F, Roupret M, Slama A, Le Fur C, Michel E, Sitbon A, Cotte FE (2012) Outcomes and general health-related quality of life among patients medically treated in general daily practice for lower urinary tract symptoms due to benign prostatic hyperplasia. World J Urol 30(3):419–426. doi:10.1007/s00345-011-0756-2 PubMedCentralPubMedCrossRef Fourcade RO, Lacoin F, Roupret M, Slama A, Le Fur C, Michel E, Sitbon A, Cotte FE (2012) Outcomes and general health-related quality of life among patients medically treated in general daily practice for lower urinary tract symptoms due to benign prostatic hyperplasia. World J Urol 30(3):419–426. doi:10.​1007/​s00345-011-0756-2 PubMedCentralPubMedCrossRef
26.
go back to reference Trueman P, Hood SC, Nayak US, Mrazek MF (1999) Prevalence of lower urinary tract symptoms and self-reported diagnosed ‘benign prostatic hyperplasia’, and their effect on quality of life in a community-based survey of men in the UK. BJU Int 83(4):410–415PubMedCrossRef Trueman P, Hood SC, Nayak US, Mrazek MF (1999) Prevalence of lower urinary tract symptoms and self-reported diagnosed ‘benign prostatic hyperplasia’, and their effect on quality of life in a community-based survey of men in the UK. BJU Int 83(4):410–415PubMedCrossRef
27.
go back to reference Balogh O, Brodszky V, Gulacsi L, Heredi E, Herszenyi K, Jokai H, Karpati S, Baji P, Remenyik E, Szegedi A, Hollo P (2014) Cost-of-illness in patients with moderate to severe psoriasis: a cross-sectional survey in Hungarian dermatological centres. Eur J Health Econ HEPAC 15(Suppl 1):S101–S109. doi:10.1007/s10198-014-0599-z PubMedCrossRef Balogh O, Brodszky V, Gulacsi L, Heredi E, Herszenyi K, Jokai H, Karpati S, Baji P, Remenyik E, Szegedi A, Hollo P (2014) Cost-of-illness in patients with moderate to severe psoriasis: a cross-sectional survey in Hungarian dermatological centres. Eur J Health Econ HEPAC 15(Suppl 1):S101–S109. doi:10.​1007/​s10198-014-0599-z PubMedCrossRef
28.
go back to reference Rencz F, Brodszky V, Péntek M, Balogh O, Remenyik É, Szegedi A, Holló P, Kárpáti S, Jókai H, Herszényi K, Herédi E, Szántó S, Gulácsi L (2014) Disease burden of psoriasis associated with psoriatic arthritis in Hungary. Orv Hetil 155(48):1913–1921PubMedCrossRef Rencz F, Brodszky V, Péntek M, Balogh O, Remenyik É, Szegedi A, Holló P, Kárpáti S, Jókai H, Herszényi K, Herédi E, Szántó S, Gulácsi L (2014) Disease burden of psoriasis associated with psoriatic arthritis in Hungary. Orv Hetil 155(48):1913–1921PubMedCrossRef
29.
go back to reference Pentek M, Bereczki D, Gulacsi L, Mikudina B, Aranyi Z, Juhos V, Baji P, Brodszky V (2013) Survey of adults living with epilepsy in Hungary: health-related quality of life and costs. Ideggyogyaszati szemle 66(7–8):251–261PubMed Pentek M, Bereczki D, Gulacsi L, Mikudina B, Aranyi Z, Juhos V, Baji P, Brodszky V (2013) Survey of adults living with epilepsy in Hungary: health-related quality of life and costs. Ideggyogyaszati szemle 66(7–8):251–261PubMed
34.
go back to reference Carballido J, Ruiz-Cerda JL, Unda M, Baena V, Campoy P, Manasanch J, Slof J (2008) Economic evaluation of medical treatment of benign prostatic hyperplasia (BPH) in the specialised care setting in Spain. Application to the cost-effectiveness of two drugs frequently used in its treatment. Actas Urol Esp 32(9):916–925PubMedCrossRef Carballido J, Ruiz-Cerda JL, Unda M, Baena V, Campoy P, Manasanch J, Slof J (2008) Economic evaluation of medical treatment of benign prostatic hyperplasia (BPH) in the specialised care setting in Spain. Application to the cost-effectiveness of two drugs frequently used in its treatment. Actas Urol Esp 32(9):916–925PubMedCrossRef
40.
go back to reference Taub DA, Wei JT (2006) The economics of benign prostatic hyperplasia and lower urinary tract symptoms in the United States. Curr Urol Rep 7(4):272–281PubMedCrossRef Taub DA, Wei JT (2006) The economics of benign prostatic hyperplasia and lower urinary tract symptoms in the United States. Curr Urol Rep 7(4):272–281PubMedCrossRef
Metadata
Title
Cost of illness of medically treated benign prostatic hyperplasia in Hungary
Authors
Fanni Rencz
Ágnes Kovács
Valentin Brodszky
László Gulácsi
Zalán Németh
Gábor János Nagy
János Nagy
István Buzogány
Géza Böszörményi-Nagy
Attila Majoros
Péter Nyirády
Publication date
01-08-2015
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 8/2015
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-015-1028-7

Other articles of this Issue 8/2015

International Urology and Nephrology 8/2015 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.