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01-09-2014 | Urology - Original Paper

Advanced therapeutic directions to treat the underactive bladder

Authors: Phillip P. Smith, Pradeep Tyagi, George A. Kuchel, Subrata Pore, Christopher Chermansky, Michael Chancellor, Naoki Yoshimura, Peter Levanovich

Published in: International Urology and Nephrology | Special Issue 1/2014

Abstract

Muscarinic agonists are the most commonly used agents for treating the underactive bladder (UAB). However, because of the absence of pharmacologic specificity for bladder-only effects and possibly as a result of degenerative and other post-synaptic changes involving detrusor smooth muscle cells, they are simply not effective and side effects are common. If safe and effective therapy for UAB is made available, then most experts agree that the potential market would exceed industry expectations, just as antimuscarinic agents for overactive bladder did in the late 1990s. The pharmaceutical and biotechnology industries that have a pipeline to urology and women’s health should consider UAB as a potential target condition. A rational approach to treating the pathology of UAB is presented with a discussion of potential targets that may allow the development of safe and effective agents for the treatment of UAB.

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Title: Advanced therapeutic directions to treat the underactive bladder
Authors: Phillip P. Smith
Pradeep Tyagi
George A. Kuchel
Subrata Pore
Christopher Chermansky
Michael Chancellor
Naoki Yoshimura
Peter Levanovich
Publication date: 01-09-2014
Publisher: Springer Netherlands
Published in: International Urology and Nephrology / Issue Special Issue 1/2014
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-014-0809-8

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