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International Urology and Nephrology
Published in: International Urology and Nephrology 10/2014

01-10-2014 | Nephrology - Original Paper

Effect of continuous positive airway pressure on serum cystatin C among obstructive sleep apnea syndrome patients

Authors: Xiao-Bin Zhang, Xing-Tang Jiang, Qi-Chang Lin, Xiao Chen, Hui-Qing Zeng

Published in: International Urology and Nephrology | Issue 10/2014

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Abstract

Purpose

The purpose of the present study was to evaluate the influence of continuous positive airway pressure (CPAP) on serum cystatin C, a novel biomarker of early renal impairment, among obstructive sleep apnea (OSA) patients.

Materials and methods

Newly diagnosed severe OSA patients who treated with CPAP for 3 months were enrolled from two sleep laboratories. Serum biomarkers of renal impairment, cystatin C, creatinine and estimated glomerular filtration rate (eGFR), were detected before and after CPAP treatment.

Results

A total of 39 severe OSA patients were enrolled, 29 (74.4 %) were male, and mean age was 51.2 ± 12.2 years. After CPAP treatment, there were no changes of creatinine and eGFR (77.80 ± 20.00 vs. 75.3 ± 16.60 and 98.69 ± 31.74 vs. 100.20 ± 28.30, all p > 0.05), but cystatin C declined significantly (0.87 ± 0.18 vs. 0.77 ± 0.21, p = 0.000).

Conclusion

CPAP can decrease cystatin C levels among severe OSA patients and may prevent the latent renal impairment.
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Metadata
Title
Effect of continuous positive airway pressure on serum cystatin C among obstructive sleep apnea syndrome patients
Authors
Xiao-Bin Zhang
Xing-Tang Jiang
Qi-Chang Lin
Xiao Chen
Hui-Qing Zeng
Publication date
01-10-2014
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 10/2014
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-014-0779-x

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