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01-12-2014 | Nephrology - Review

Organ cross talk and remote organ damage following acute kidney injury

Authors: Rele Ologunde, Hailin Zhao, Kaizhi Lu, Daqing Ma

Published in: International Urology and Nephrology | Issue 12/2014

Abstract

Increasing evidence suggests that acute kidney injury (AKI) mediates a systemic response that can lead to multiple organ failure. AKI may manifest in a variety of clinical scenarios including kidney transplantation and is associated with a significantly high mortality. It has been postulated that specific pro-inflammatory cytokines, including IL-1β, IL-6, and TNF-α, may mediate a systemic response, resulting in recruitment of pro-inflammatory cells leading to organ failure. However, the specific mechanism by which the cytokine cascade results in distant organ damage is yet to be determined. Furthermore, it remains unclear as to whether cytokines mediate similar or differing responses in different end organs. This review summarizes the effects of AKI on remote organs and explores the role of systemic cytokines in mediating distant organ damage.

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Title: Organ cross talk and remote organ damage following acute kidney injury
Authors: Rele Ologunde
Hailin Zhao
Kaizhi Lu
Daqing Ma
Publication date: 01-12-2014
Publisher: Springer Netherlands
Published in: International Urology and Nephrology / Issue 12/2014
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-014-0766-2

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Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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Stress urinary incontinence and visceral adipose index: a new risk parameter

Depression in patients with chronic kidney disease on dialysis in Saudi Arabia

Septic complications and hospital admissions after transrectal ultrasound-guided prostate biopsy: incidence rates and outcomes in 913 consecutive biopsies

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