Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

ACC 2024 Congress

Catch up on all the top stories and latest evidence in cardiology research with our ACC 2024 Congress hub page.
ADVANCED SEARCH
Log in
Top
International Urology and Nephrology
Published in: International Urology and Nephrology 4/2013

01-08-2013 | Nephrology - Original Paper

Oxidative stress in patients treated with continuous ambulatory peritoneal dialysis (CAPD) and the significant role of vitamin C and E supplementation

Authors: Georgios Boudouris, Ioannis I. Verginadis, Yannis V. Simos, Andreas Zouridakis, Vasilios Ragos, Spyridon Ch. Karkabounas, Angelos M. Evangelou

Published in: International Urology and Nephrology | Issue 4/2013

Login to get access

Abstract

Purpose

Chronic renal failure patients undergoing peritoneal dialysis (PD) are characterized by increased oxidative stress (OS), which is associated with enhanced cardiovascular risk. Moreover, oxidative stress also contributes to peritoneal membrane changes and ultrafiltration failure. The aim of this study was to evaluate OS in PD patients and the effect of treatment with ascorbic acid and α-tocopherol.

Methods

Plasma, erythrocyte, urine, and peritoneal effluent samples from 20 patients on PD were evaluated for glutathione peroxidase and superoxide dismutase activity, total antioxidant capacity (TAC) and malondialdehyde (MDA) levels, as well as protein carbonyl formation, before and after administration of vitamin C, alone or in combination with vitamin E, in comparison with 10 apparently healthy control individuals.

Results

All studied markers showed enhanced OS in the PD group, compared to controls. The supplementation of vitamin C and E resulted in improvements of all the OS markers, as indicated by increased erythrocyte antioxidant enzymes activity and TAC levels, as well as decreased MDA concentration and carbonyl compound formation.

Conclusions

The oral supplementation of antioxidant vitamins C and E, in combination, can lead to decreased OS, thus providing a useful and cost-effective therapeutic option in PD patients.
Literature
1.
Vanholder R, Massy Z, Argiles A et al (2005) Chronic kidney disease as cause of cardiovascular morbidity and mortality. Nephrol Dial Transplant 20:1048–1056PubMedCrossRef
2.
Van Biesen W, De Bacquer D, Verbeke F et al (2007) The glomerular filtration rate in an apparently healthy population and its relation with cardiovascular mortality during 10 years. Eur Heart J 28:478–483PubMedCrossRef
3.
Fried LF, Shlipak MG, Crump C et al (2003) Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly individuals. J Am Coll Cardiol 41:1364–1372PubMedCrossRef
4.
Kocak H, Gumuslu S, Ermis C et al (2008) Oxidative stress and asymmetric dimethylarginine is independently associated with carotid intima media thickness in peritoneal dialysis patients. Am J Nephrol 28:91–96PubMedCrossRef
5.
Arima H, Nakamoto H, Okada S et al (2006) Risk factors for vascular complications in patients on peritoneal dialysis. Adv Perit Dial 22:192–197PubMed
6.
Pecoits-Filho R, Lindholm B, Stenvinkel P (2002) The malnutrition, inflammation, and atherosclerosis (MIA) syndrome—the heart of the matter. Nephrol Dial Transplant 11:28–31CrossRef
7.
Sahin E, Göçmen AY, Koçak H (2008) The association of advanced glycation end-products with glutathione status. Ann Clin Biochem 45:369–374PubMedCrossRef
8.
Del Vecchio L, Locatelli F, Carini M (2011) What we know about oxidative stress in patients with chronic kidney disease on dialysis—clinical effects, potential treatment, and prevention. Semin Dial 24:56–64PubMedCrossRef
9.
Dursun B, Dursun E, Capraz I et al (2008) Are uremia, diabetes, and atherosclerosis linked with impaired antioxidant mechanisms? J Investig Med 56:545–552PubMed
10.
Honda K, Nitta K, Horita S et al (1999) Accumulation of advanced glycation end products in the peritoneal vasculature of continuous ambulatory peritoneal dialysis patients with low ultra-filtration. Nephrol Dial Transplant 14:1541–1549PubMedCrossRef
11.
Kaneko K, Hamada C, Tomino Y (2007) Peritoneal fibrosis intervention. Perit Dial Int Suppl 2:S82–S86
12.
Niwa T, Tsukushi S (2001) 3-deoxyglucosone and AGEs in uremic complications: inactivation of glutathione peroxidase by 3-deoxyglucosone. Kidney Int 78:S37–S41CrossRef
13.
De Vriese AS, Tilton RG, Mortier S et al (2006) Myofibroblast transdifferentiation of mesothelial cells is mediated by RAGE and contributes to peritoneal fibrosis in uraemia. Nephrol Dial Transplant 21:2549–2555PubMedCrossRef
14.
Noh H, Kim JS, Han KH et al (2006) Oxidative stress during peritoneal dialysis: implications in functional and structural changes in the membrane. Kidney Int 69:2022–2028PubMedCrossRef
15.
Gotloib L (2009) Mechanisms of cell death during peritoneal dialysis. A role for osmotic and oxidative stress. Contrib Nephrol 163:35–44PubMedCrossRef
16.
Lonn E, Yusuf S, Hoogwerf B et al (2002) HOPE Study; MICRO-HOPE study effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy. Diabetes Care 25:1919–1927PubMedCrossRef
17.
Riccioni G, Frigiola A, Pasquale S et al (2012) Vitamin C and E consumption and coronary heart disease in men. Front Biosci (Elite Ed) 4:373–380
18.
Chen AF, Chen DD, Daiber A et al (2012) Free radical biology of the cardiovascular system. Clin Sci (Lond) 123:73–91CrossRef
19.
Coombes JS, Fassett RG (2012) Antioxidant therapy in hemodialysis patients: a systematic review. Kidney Int 81:233–246PubMedCrossRef
20.
Diepeveen SH, Verhoeven GH, van der Palen J et al (2005) The effect of the initiation of renal replacement therapy on lipid profile and oxidative stress during the first 6 months of treatment. Clin Chim Acta 361:112–118PubMedCrossRef
21.
Cruz DN, Soni SS, Polanco N et al (2010) Markers of inflammation and oxidative stress in peritoneal dialysis: a comparison between high and low peritoneal transporters. J Nephrol 23:453–458PubMed
22.
Charalampidis PS, Veltsistas P, Karkabounas S et al (2009) Blue CrO5 assay: a novel spectrophotometric method for the evaluation of the antioxidant and oxidant capacity of various biological substances. Eur J Med Chem 44:4162–4168PubMedCrossRef
23.
Hong YC, Lee KH, Yi CH et al (2002) Genetic susceptibility of term pregnant women to oxidative damage. Toxicol Lett 129:255–262PubMedCrossRef
24.
Alamdari DH, Kostidou E, Paletas K et al (2005) High sensitivity enzyme-linked immunosorbent assay (ELISA) method for measuring protein carbonyl in samples with low amounts of protein. Free Radic Biol Med 39:1362–1367PubMedCrossRef
25.
Mydlík M, Derzsiová K (2004) Vitamin B6 and oxalic acid in clinical nephrology. Front Biosci 9:2901–2908CrossRef
26.
27.
Aguilera A, Bajo MA, del Peso G et al (2002) True deficiency of antioxidant vitamins E and A in dialysis patients. Relationship with clinical patterns of atherosclerosis. Adv Perit Dial 18:206–211PubMed
28.
Ece A, Gürkan F, Kervancioğlu M et al (2006) Oxidative stress, inflammation and early cardiovascular damage in children with chronic renal failure. Pediatr Nephrol 21:545–552PubMedCrossRef
29.
Domenici FA, Vannucchi MT, Jordão AA Jr et al (2005) DNA oxidative damage in patients with dialysis treatment. Ren Fail 27:689–694PubMedCrossRef
30.
Shah GM, Ross EA, Sabo A et al (1992) Effects of ascorbic acid and pyridoxine supplementation on oxalate metabolism in peritoneal dialysis patients. Am J Kidney Dis 20:42–49PubMed
31.
Mydlík M, Derzsiová K, Rácz O et al (2002) Vitamin E as an antioxidant agent in CAPD patients. Int J Artif Organs 25:373–378PubMed
32.
Palleschi S, De Angelis S, Diana L et al (2007) Reliability of oxidative stress biomarkers in hemodialysis patients: a comparative study. Clin Chem Lab Med 45:1211–1218PubMedCrossRef
33.
Dounousi E, Papavasiliou E, Makedou A et al (2006) Oxidative stress is progressively enhanced with advancing stages of CKD. Am J Kidney Dis 48:752–760PubMedCrossRef
34.
Ahmadpoor P, Eftekhar E, Nourooz-Zadeh J et al (2009) Glutathione, glutathione-related enzymes, and total antioxidant capacity in patients on maintenance dialysis. Iran J Kidney Dis 3:22–27PubMed
35.
Malliaraki N, Mpliamplias D, Kampa M et al (2003) Total and corrected antioxidant capacity in hemodialyzed patients. BMC Nephrol 4:4PubMedCrossRef
36.
Mitrogianni Z, Barbouti A, Galaris D et al (2009) Oxidative modification of albumin in predialysis, hemodialysis, and peritoneal dialysis patients. Nephron Clin Pract 113:c230–c234CrossRef
37.
Antoniades C, Tousoulis D, Tentolouris C et al (2003) Oxidative stress, antioxidant vitamins, and atherosclerosis. From basic research to clinical practice. Herz 28:628–638PubMedCrossRef
38.
Mann JF, Lonn EM, Yi Q et al (2004) HOPE investigators effects of vitamin E on cardiovascular outcomes in people with mild-to-moderate renal insufficiency: results of the HOPE study. Kidney Int 65:1375–1380PubMedCrossRef
39.
Kamgar M, Zaldivar F, Vaziri ND et al (2009) Antioxidant therapy does not ameliorate oxidative stress and inflammation in patients with end-stage renal disease. J Natl Med Assoc 101:336–344PubMed
40.
Galli F (2007) Protein damage and inflammation in uraemia and dialysis patients. Nephrol Dial Transplant Suppl 5:v20–v36CrossRef
41.
Nguyen-Khoa T, Massy ZA, De Bandt JP et al (2001) Oxidative stress and haemodialysis: role of inflammation and duration of dialysis treatment. Nephrol Dial Transplant 16:335–340PubMedCrossRef
42.
Diepeveen SH, Verhoeven GW, Van Der Palen J et al (2005) Effects of atorvastatin and vitamin E on lipoproteins and oxidative stress in dialysis patients: a randomised-controlled trial. J Intern Med 257:438–445PubMedCrossRef
43.
Piroddi M, Pilolli F, Aritomi M et al (2012) Vitamin E as a functional and biocompatibility modifier of synthetic hemodialyzer membranes: an overview of the literature on vitamin E-modified hemodialyzer membranes. Am J Nephrol 35:559–572PubMedCrossRef
Metadata
Title
Oxidative stress in patients treated with continuous ambulatory peritoneal dialysis (CAPD) and the significant role of vitamin C and E supplementation
Authors
Georgios Boudouris
Ioannis I. Verginadis
Yannis V. Simos
Andreas Zouridakis
Vasilios Ragos
Spyridon Ch. Karkabounas
Angelos M. Evangelou
Publication date
01-08-2013
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 4/2013
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-012-0334-6

Other articles of this Issue 4/2013

International Urology and Nephrology 4/2013 Go to the issue

Nephrology - Original Paper

High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients

Urology - Original Paper

Gap junction expression and the effects of gap junction inhibitors in overactive bladder models: does ovariectomy have a role?

Nephrology - Original Paper

Short- and long-term efficacy of levamisole in children with steroid-sensitive nephrotic syndrome

Nephrology - Original Paper

Appetite course over time and the risk of death in patients on chronic hemodialysis

Nephrology - Original Paper

Alprostadil plays a protective role in contrast-induced nephropathy in the elderly

Urology - Original Paper

Comparison of standardized pre- and postoperative functional pelvic cine-MRI in patients with a bulbourethral composite suspension due to post-prostatectomy incontinence

ACC 2024 Congress Coverage

Cardiology Video

Highlights from the ACC 2024 Congress

Watch now

Watch official videos from the ACC congress summarizing key highlights from the last year in heart failure, cardiomyopathies, valvular disease, pulmonary vascular disease, and pediatric cardiology.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits