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International Urology and Nephrology
Published in: International Urology and Nephrology 3/2008

01-09-2008 | Nephrology-Review

Renal senescence in 2008: progress and challenges

Authors: Xin J. Zhou, Ramesh Saxena, Zhihong Liu, N. D. Vaziri, Fred G. Silva

Published in: International Urology and Nephrology | Issue 3/2008

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Abstract

Kidneys are significantly affected by profound anatomic and functional changes with senescence. These changes lead to decline in glomerular filtration rate, decreased urinary concentrating and diluting ability, diminished urinary acidification, and impaired potassium clearance, to list a few. Such changes make the elderly prone to drug toxicity and serious fluid and electrolyte imbalance. While the entire mystery of aging is far from being clear, the role of oxidative stress, telomere length, Klotho gene expression, and the renin angiotensin system seem to be the key mechanisms involved in aging. Aging, being a complex process, involves an array of intertwined molecular pathways. Simultaneous study of multiple molecular pathways in parallel could provide invaluable information in understanding the clinical course of kidney aging and elucidating mechanisms that play key roles in the aging process. A better understanding of these mechanisms may help to preserve renal function, improve morbidity and mortality, and hopefully reduce healthcare costs for the aging population.
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Metadata
Title
Renal senescence in 2008: progress and challenges
Authors
Xin J. Zhou
Ramesh Saxena
Zhihong Liu
N. D. Vaziri
Fred G. Silva
Publication date
01-09-2008
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 3/2008
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-008-9405-0

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