Published in:
14-12-2022 | COVID-19
Association between thromboembolic events and COVID-19 infection within 30 days: a case–control study among a large sample of adult hospitalized patients in the United States, March 2020–June 2021
Authors:
Ya-Lin A. Huang, Hussain Yusuf, Alys Adamski, Joy Hsu, James Baggs, Rehab Auf, Stacey Adjei, Rhett Stoney, W. Craig Hooper, Eloisa Llata, Emilia H. Koumans, Jean Y. Ko, Sebastian Romano, Tegan K. Boehmer, Aaron M. Harris
Published in:
Journal of Thrombosis and Thrombolysis
|
Issue 1/2023
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Abstract
The association between thromboembolic events (TE) and COVID-19 infection is not completely understood at the population level in the United States. We examined their association using a large US healthcare database. We analyzed data from the Premier Healthcare Database Special COVID-19 Release and conducted a case–control study. The study population consisted of men and non-pregnant women aged ≥ 18 years with (cases) or without (controls) an inpatient ICD-10-CM diagnosis of TE between 3/1/2020 and 6/30/2021. Using multivariable logistic regression, we assessed the association between TE occurrence and COVID-19 diagnosis, adjusting for demographic factors and comorbidities. Among 227,343 cases, 15.2% had a concurrent or prior COVID-19 diagnosis within 30 days of their index TE. Multivariable regression analysis showed a statistically significant association between a COVID-19 diagnosis and TE among cases when compared to controls (adjusted odds ratio [aOR] 1.75, 95% CI 1.72–1.78). The association was more substantial if a COVID-19 diagnosis occurred 1–30 days prior to index hospitalization (aOR 3.00, 95% CI 2.88–3.13) compared to the same encounter as the index hospitalization. Our findings suggest an increased risk of TE among persons within 30 days of being diagnosed COVID-19, highlighting the need for careful consideration of the thrombotic risk among COVID-19 patients, particularly during the first month following diagnosis.