Published in:
01-06-2007
Platelets from genome to proteome and beyond
Author:
Richard C. Becker
Published in:
Journal of Thrombosis and Thrombolysis
|
Issue 3/2007
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Excerpt
Single gene(mendelian) disorders with clearly identified and profound effects provide the most dramatic examples of genotype-phenotype relations. An example in the case of coronary atherosclerosis is familial hypercholesterolemia [
1,
2]; however, in a majority of instances, atherosclerosis, and its most clinically important phenotype, thrombosis, is the result of complex traits (gene–gene, gene–environment interactions) (Reviewed in reference
3). …