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Reviews in Endocrine and Metabolic Disorders
Published in: Reviews in Endocrine and Metabolic Disorders 3/2016

01-09-2016

Beyond acne: Current aspects of sebaceous gland biology and function

Authors: Christos C. Zouboulis, Mauro Picardo, Qiang Ju, Ichiro Kurokawa, Dániel Törőcsik, Tamás Bíró, Marlon R. Schneider

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 3/2016

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Abstract

The sebaceous gland is most commonly found in association with a hair follicle. Its traditional function is the holocrine production of sebum, a complex mixture of lipids, cell debris, and other rather poorly characterized substances. Due to the gland’s central role in acne pathogenesis, early research had focused on its lipogenic activity. Less studied aspects of the sebaceous gland, such as stem cell biology, the regulation of cellular differentiation by transcription factors, the significance of specific lipid fractions, the endocrine and specially the neuroendocrine role of the sebaceous gland, and its contribution to the innate immunity, the detoxification of the skin, and skin aging have only recently attracted the attention of researchers from different disciplines. Here, we summarize recent multidisciplinary progress in sebaceous gland research and discuss how sebaceous gland research may stimulate the development of novel therapeutic strategies targeting specific molecular pathways of the pathogenesis of skin diseases.
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Metadata
Title
Beyond acne: Current aspects of sebaceous gland biology and function
Authors
Christos C. Zouboulis
Mauro Picardo
Qiang Ju
Ichiro Kurokawa
Dániel Törőcsik
Tamás Bíró
Marlon R. Schneider
Publication date
01-09-2016
Publisher
Springer US
Published in
Reviews in Endocrine and Metabolic Disorders / Issue 3/2016
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI
https://doi.org/10.1007/s11154-016-9389-5

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