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Reviews in Endocrine and Metabolic Disorders

Published in:

01-06-2014

Adiponectin signaling in the liver

Authors: Terry P. Combs, Errol B. Marliss

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 2/2014

Abstract

High glucose production contributes to fed and fasted hyperglycemia in Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D). The breakdown of the adiponectin signaling pathway in T1D and the reduction of circulating adiponectin in T2D contribute to this abnormal increase in glucose production. Sufficient amounts of insulin could compensate for the loss of adiponectin signaling in T1D and T2D and reduce hyperglycemia. However, the combination of low adiponectin signaling and high insulin resembles an insulin resistance state associated with cardiovascular disease, fatty liver disease and decreased life expectancy. The future development of “adiponectin sensitizers”, medications that correct the deficiency in adiponectin signaling, could restore the metabolic balance in T1D and T2D and reduce the need for insulin. This article reviews the adiponectin signaling pathway in the liver through T-cadherin, AdipoR1, AdipoR2, AMPK, ceramidase activity, APPL1 and the recently discovered Suppressor Of Glucose from Autophagy (SOGA).

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Title: Adiponectin signaling in the liver
Authors: Terry P. Combs
Errol B. Marliss
Publication date: 01-06-2014
Publisher: Springer US
Published in: Reviews in Endocrine and Metabolic Disorders / Issue 2/2014
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI: https://doi.org/10.1007/s11154-013-9280-6

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