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Reviews in Endocrine and Metabolic Disorders

Published in:

Open Access 01-12-2013

Estrogen, astrocytes and the neuroendocrine control of metabolism

Authors: E. Fuente-Martin, C. Garcia-Caceres, E. Morselli, D. J. Clegg, J. A. Chowen, B. Finan, R. D. Brinton, M. H. Tschöp

Published in: Reviews in Endocrine and Metabolic Disorders | Issue 4/2013

Abstract

Obesity, and its associated comorbidities such as type 2 diabetes, cardiovascular diseases, and certain cancers, represent major health challenges. Importantly, there is a sexual dimorphism with respect to the prevalence of obesity and its associated metabolic diseases, implicating a role for gonadal hormones. Specifically, estrogens have been demonstrated to regulate metabolism perhaps by acting as a leptin mimetic in the central nervous system (CNS). CNS estrogen receptors (ERs) include ER alpha (ERα) and ER beta (ERβ), which are found in nuclear, cytoplasmic and membrane sites throughout the brain. Additionally, estrogens can bind to and activate a G protein-coupled estrogen receptor (GPER), which is a membrane-associated ER. ERs are expressed on neurons as well as glia, which are known to play a major role in providing nutrient supply for neurons and have recently received increasing attention for their potentially important involvement in the CNS regulation of systemic metabolism and energy balance. This brief overview summarizes data focusing on the potential role of astrocytic estrogen action as a key component of estrogenic modulation responsible for mediating the sexual dimorphism in body weight regulation and obesity.

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Title: Estrogen, astrocytes and the neuroendocrine control of metabolism
Authors: E. Fuente-Martin
C. Garcia-Caceres
E. Morselli
D. J. Clegg
J. A. Chowen
B. Finan
R. D. Brinton
M. H. Tschöp
Publication date: 01-12-2013
Publisher: Springer US
Published in: Reviews in Endocrine and Metabolic Disorders / Issue 4/2013
Print ISSN: 1389-9155
Electronic ISSN: 1573-2606
DOI: https://doi.org/10.1007/s11154-013-9263-7

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Role of oxytocin signaling in the regulation of body weight

Disruption of neurogenesis by hypothalamic inflammation in obesity or aging

Natural birth-induced UCP2 in brain development

Insulin and glucagon signaling in the central nervous system

Orexin: Pathways to obesity resistance?

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

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