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Quality of Life Research
Published in: Quality of Life Research 4/2022

01-04-2022 | Macular Degeneration

Identifying the content for an item bank and computerized adaptive testing system to measure the impact of age-related macular degeneration on health-related quality of life

Authors: Eva K. Fenwick, Ester P. X. Lee, Ryan E. K. Man, Kam Chun Ho, Raymond P. Najjar, Dan Milea, Kelvin Y. C. Teo, Anna C. S. Tan, Shu Yen Lee, Ian Yew San Yeo, Gavin S. W. Tan, Ranjana Mathur, Tien Yin Wong, Chui Ming Gemmy Cheung, Ecosse L. Lamoureux

Published in: Quality of Life Research | Issue 4/2022

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Abstract

Purpose

We are developing an age-related macular degeneration (AMD) health-related quality of life (HRQoL) item bank, applicable to Western and Asian populations. We report primarily on content generation and refinement, but also compare the HRQoL issues reported in our study with Western studies and current AMD-HRQoL questionnaires.

Methods

In this cross-sectional, qualitative study of AMD patients attending the Singapore National Eye Centre (May–December 2019), items/domains were generated from: (1) AMD-specific questionnaires; (2) published articles; (3) focus groups/semi-structured interviews with AMD patients (n = 27); and (4) written feedback from retinal experts. Following thematic analysis, items were systematically refined to a minimally representative set and pre-tested using cognitive interviews with 16 AMD patients.

Results

Of the 27 patients (mean ± standard deviation age 67.9 ± 7.0; 59.2% male), 18 (66.7%), two (7.4%), and seven (25.9%) had no, early-intermediate, and late/advanced AMD (better eye), respectively. Whilst some HRQoL issues, e.g. activity limitation, mobility, lighting, and concerns were similarly reported by Western patients and covered by other questionnaires, others like anxiety about intravitreal injections, work tasks, and financial dependency were novel. Overall, 462 items within seven independent HRQoL domains were identified: Activity limitation, Lighting, Mobility, Emotional, Concerns, AMD management, and Work. Following item refinement, items were reduced to 219, with 31 items undergoing amendment.

Conclusion

Our 7-domain, 219-item AMD-specific HRQoL instrument will undergo psychometric testing and calibration for computerized adaptive testing. The future instrument will enable users to precisely, rapidly, and comprehensively quantify the HRQoL impact of AMD and associated treatments, with item coverage relevant across several populations.
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Metadata
Title
Identifying the content for an item bank and computerized adaptive testing system to measure the impact of age-related macular degeneration on health-related quality of life
Authors
Eva K. Fenwick
Ester P. X. Lee
Ryan E. K. Man
Kam Chun Ho
Raymond P. Najjar
Dan Milea
Kelvin Y. C. Teo
Anna C. S. Tan
Shu Yen Lee
Ian Yew San Yeo
Gavin S. W. Tan
Ranjana Mathur
Tien Yin Wong
Chui Ming Gemmy Cheung
Ecosse L. Lamoureux
Publication date
01-04-2022
Publisher
Springer International Publishing
Published in
Quality of Life Research / Issue 4/2022
Print ISSN: 0962-9343
Electronic ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-021-02989-w

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